African trypanosomiasis : clinical symptoms, diagnosis and treatment / Gerald T. Hughes, editor.

Format:

Book

Contributor:

Hughes, Gerald T., editor.

Series:

Parasites and Parasitic Diseases

Language:

English

Subjects (All):

African trypanosomiasis.

Physical Description:

1 online resource (106 p.)

Place of Publication:

New York : Nova Biomedical, 2016.

Summary:

Human African trypanosomiasis or sleeping sickness is caused by infection with the morphologically indistinguishable subspecies Trypanosoma brucei rhodesiense (in East and Southern Africa) and Trypanosoma brucei gambiense (in West and Central Africa). The disease is presently almost under control and less than 4000 cases are currently reported. In both, T. b. rhodesiense and T. b. gambiense infection, after the injection of infective metacyclic trypanosomes with tsetse fly vector saliva, the parasites establish in the skin, differentiate to the bloodstream stage and spread via the local draining lymph node into the vascular system. In this book, Chapter One presents an overview of the current epidemiology, clinical features, diagnosis and treatment options. Chapter Two provides an in-depth review of diagnostic methods for African trypanosomiasis. Chapter Three discusses the use of aminoadamantane derivatives against Trypanosoma brucei.

Contents:

AFRICAN TRYPANOSOMIASIS CLINICAL SYMPTOMS, DIAGNOSIS AND TREATMENT; AFRICAN TRYPANOSOMIASIS CLINICAL SYMPTOMS, DIAGNOSIS AND TREATMENT; CONTENTS ; PREFACE; Chapter 1 HUMAN AFRICAN TRYPANOSOMIASIS: CLINICAL SYMPTOMS, DIAGNOSIS AND TREATMENT ; ABSTRACT ; INTRODUCTION ; EPIDEMIOLOGICAL OVERVIEW ; Host -Parasite Interaction; Early Stage Host-Parasite Interaction ; Late Stage Host-Parasite Interaction ; Striking Features ; Clinical Presentation ; Early Stage Clinical Presentation; Late Stage Clinical Presentation ; Striking Features ; Diagnosis ; Early Stage Diagnosis

Late Stage Diagnosis Treatment Options ; Early Stage Treatment ; Late Stage Treatment; CONCLUSION; REFERENCES ; BIOGRAPHICAL SKETCH ; Chapter 2 DIAGNOSTIC METHODS FOR AFRICAN TRYPANOSOMIASIS ; ABSTRACT ; DIAGNOSIS OF ANIMAL AFRICAN TRYPANOSOMIASIS (AAT) ; PARASITOLOGICAL DIAGNOSIS ; Morphology ; Microscopy ; The Subgenus Nannomonas (the Congolense Group); Trypanozoon ; Serodiagnosis ; Antibody Detection Tests ; Antigen Detection Tests ; Molecular Diagnostic Methods ; HUMAN AFRICAN TRYPANOSOMIASIS (SLEEPING SICKNESS) ; Clinical Features ; Trypanosoma Brucei Gambiense

Laboratory Diagnosis of T. b. Gambiense HAT Disease Stage Determination: Cerebrospinal Fluid Examination ; Management of Serologically Suspect Individuals: Follow up of Patients ; Trypanosoma brucei rhodesiense ; CONCLUSION ; REFERENCES ; Chapter 3 AMINOADAMANTANE DERIVATIVES AGAINST TRYPANOSOMA BRUCEI ; CONCLUSION ; REFERENCES ; BIBLIOGRAPHY ; INDEX ; Blank Page

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-63484-723-7