Intrinsically disordered proteins (idps) : structural characterization, therapeutic applications and future directions / Violet Weber, Editor.

Format:

Book

Contributor:

Weber, Violet, editor.

Series:

Protein biochemistry, synthesis, structure, and cellular functions series.

Protein Biochemistry, Synthesis, Structure and Cellular Functions

Language:

English

Subjects (All):

Proteins--Structure.

Proteins.

Proteins--Conformation.

Physical Description:

1 online resource (117 p.)

Place of Publication:

Hauppauge, New York : Nova Science Publishers, Inc., 2016.

Summary:

Intrinsically disordered proteins (IDPs) are biomolecules that do not have a definite 3D structure; their role in the biochemical network of a cell relates to their ability to switch rapidly among different secondary and tertiary structures. The emergence of IDPs has challenged the classical protein structure-function paradigm. IDPs play an important role in cellular regulation, signaling and control in health and disease. However, the unusual biophysics of these proteins makes structural characterization of IDPs and their complexes not only challenging but often resulting in opposite conclusions. This book studies the structural characterization and future directions of IDPs. Chapter One focuses on the DNA-binding IDPs and how intrinsic disorder affects their function. Chapter Two discusses the use of a computer atomistic simulation for the structural analysis of IDPs. The final chapter, Chapter Three, examines two long-standing contradictions concerning dimerization and membrane-binding activities of IDPs; provides an explanation of these discrepancies; and demonstrates how the resolution of these critical issues in the field results in the expanded understanding of cell function with multiple applications in biology and medicine.

Contents:

INTRINSICALLY DISORDERED PROTEINS (IDPS): STRUCTURAL CHARACTERIZATION, THERAPEUTIC APPLICATIONS AND FUTURE DIRECTIONS; INTRINSICALLY DISORDERED PROTEINS (IDPS): STRUCTURAL CHARACTERIZATION, THERAPEUTIC APPLICATIONS AND FUTURE DIRECTIONS; Library of Congress Cataloging-in-Publication Data; CONTENTS; PREFACE; Chapter 1: INTRINSIC DISORDER INDNA-BINDING PROTEINS; ABSTRACT; INTRODUCTION; 1. CHROMATIN ARCHITECTURAL PROTEINS; 2. TRANSCRIPTION FACTORS; 3. INTRINSICALLY DISORDERED PROTEINS IN DNA METABOLISM; CONCLUSION; REFERENCES

Chapter 2: STRUCTURAL ANALYSIS OF INTRINSICALLY DISORDERED PROTEINS: COMPUTER ATOMISTIC SIMULATIONAbstract; 1. Introduction; 2. The Tau Protein; 3. Initial Configuration and Dynamical Evolution; 4. Secondary Structures; 5. Tertiary Structures; 6. Fit of Experimental SAXS Data; 7. Transient Structures; 8. Conclusion; Acknowledgment; References; Chapter 3: BIOPHYSICAL CHARACTERIZATION OF INTRINSICALLY DISORDERED PROTEINS AND THEIR COMPLEXES: CHALLENGES AND CONTRADICTIONS; ABSTRACT; INTRODUCTION; DO IDPS FOLD UPON BINDING TO THE CELL MEMBRANE?; DO IDPS DIMERIZE?; CONCLUSION; REFERENCES; INDEX

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Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

1-63484-422-X