Cocaine abuse : behavior, pharmacology, and clinical applications / [edited by] Stephen T. Higgins, Jonathan L. Katz.

Format:

Book

Contributor:

Higgins, Stephen T.

Katz, Jonathan L.

Language:

English

Subjects (All):

Cocaine abuse--Physiological aspects.

Cocaine abuse.

Cocaine abuse--Treatment.

Cocaine--Psychological aspects.

Cocaine.

Physical Description:

1 online resource (471 p.)

Place of Publication:

San Diego : Academic Press, c1998.

Language Note:

English

Summary:

Cocaine abuse remains a major public health problem and contributes to many of our most disturbing social problems, including the spread of infectious disease, crime, violence, and neonatal drug exposure. Cocaine abuse results from a complex interplay of behavioral, pharmacological, and neurobiological determinants. While a complete understanding of cocaine abuse is currently beyond us, significant progress has been made in preclinical research on fundamental determinants of this disorder. These advances are critically reviewed in the first section of this volume. Important advances also have

Contents:

Front Cover; Cocaine Abuse: Behavior, Pharmacology, and Clinical Applications; Copyright Page; Contents; Contributors; Foreword; Preface; Chapter 1. Basic Pharmacological Mechanisms of Cocaine; Introduction; Regulation of Transporter Function; Neurochemical Effects of Cocaine Measured in Vivo; Acute and Chronic Effects of Cocaine on Receptors; Molecular Mechanisms of Cocaine Effects; Summary; References; Chapter 2. Neuroanatomical Bases of the Reinforcing Stimulus Effects of Cocaine; Introduction; The Mesoaccumbens Ascending Dopaminergic Pathway; The Medial Prefrontal Cortex

The Amygdala's Role in Behavioral Effects of Self-Administered Cocaine Newly Charted Territories: Subiculum, Basal Nucleus, and Pedunculopontine; Summary and Implications for Cortico-Striato-Pallido-Thalamic Circuitry; References; Chapter 3. Behavioral Pharmacology of Cocaine and the Determinants of Abuse Liability; Introduction; Psychomotor-Stimulant Effects of Cocaine; Interoceptive Effects of Cocaine; Contextual Determinants of the Reinforcing Effects of Cocaine; Alternatives to Cocaine Self-Administration; Suppression of Cocaine-Maintained Responding; Summary; References

Chapter 4. Behavioral-Environmental Determinants of the Reinforcing Functions of Cocaine Introduction; Evaluation of Cocaine Reinforcement; Experimental Events Modulating Cocaine Reinforcement; Environmental Context; Processes Modulating Reinforcement; Summary; References; Chapter 5. Tolerance and Sensitization to Cocaine: An Integrated View; Introduction; Tolerance; Sensitization; Tolerance and Sensitization in Cocaine Abuse; References; Chapter 6. Preclinical Evaluation of Pharmacotherapies for Cocaine Abuse; Introduction; Drug Discrimination; Intravenous Drug Self-Administration

Antibodies to Cocaine Conclusions; References; Chapter 7. Prenatal Exposure to Cocaine; Introduction; Case Studies; Epidemiological Studies; Nonhuman Experimental Studies; Conclusions; References; Chapter 8. Cocaine Self-Administration Research: Implications for Rational Pharmacotherapy; Introduction; Ethical and Safety Issues Involved in Administering Cocaine to Humans; Assessing Cocaine Self-Administration in Human Research Participants; The Use of Cocaine Self-Administration Procedures to Inform Cocaine Pharmacotherapy; Conclusion; References

Chapter 9. Evaluation of Potential Pharmacotherapies: Response to Cocaine Challenge in the Human Laboratory Introduction; Mechanisms of Pharmacotherapy; Approaches to Pharmacotherapy Development; Studies of Potential Pharmacotherapies Using the Laboratory Challenge Method; Conclusions; References; Chapter 10. Controlled Laboratory Studies on the Effects of Cocaine in Combination with Other Commonly Abused Drugs in Humans; Introduction; Patterns of Multiple Drug Abuse among Cocaine Abusers; Cocaine-Alcohol Combinations; Cocaine-Opioid Combinations; Cocaine-Marijuana Combinations

Cocaine-Nicotine Combinations

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-02877-0

9786611028770

0-08-052926-7

OCLC:

476085771