Snake venoms and envenomation : modern trends and future prospects / Yuri N. Utkin, and Arcadius V. Krivoshein, editors.

Format:

Book

Contributor:

Utkin, Yuri N., editor.

Krivoshein, Arcadius V., editor.

Series:

Medicine and Biology Research Developments

Language:

English

Subjects (All):

Poisonous snakes--Venom.

Poisonous snakes.

Toxins.

Physical Description:

1 online resource (315 p.)

Place of Publication:

New York : Nova Publishers, 2016.

Language Note:

English

Summary:

Snake bites are a major health concern, especially in tropical countries. Understanding the pathology of envenomation and chemical composition of snake venoms is important in the development of medical countermeasures (including, but not limited to, antivenoms). Furthermore, snake venoms can be considered natural "combinatorial libraries" of proteins and peptides. Thus, it is not surprising that components of snake venom have been found extensively useful in biomedical research as well as clinical use for treating diseases as diverse as cancer and muscle pain. In this book, well-known scientists from the Americas, Asia, and Europe discuss recent trends and outlooks in regards to snake venom research. A distinctively broader coverage of the subject is given, with topics ranging from protein biochemistry to pathology. Several chapters highlight protein biochemistry and enzymology of snake venoms, immune response to envenomation and antivenoms, production and use of snake venom components as antigens for antivenom preparation, and the therapeutic value of snake venom components in the treatment of various diseases. A comprehensive and authoritative monograph, this book will be equally interesting to both established researchers and graduate students interested in toxinology and pathology of envenomation.

Contents:

SNAKE VENOMS AND ENVENOMATION MODERN TRENDS AND FUTURE PROSPECTS; SNAKE VENOMS AND ENVENOMATION MODERN TRENDS AND FUTURE PROSPECTS; Library of Congress Cataloging-in-Publication Data; CONTENTS; PREFACE; SECTION ONE: GENERAL ASPECTS; Chapter 1: SNAKES: DIVERSITY, EPIDEMIOLOGY AND ENVENOMATION; ABSTRACT; GENERAL ASPECTS; EPIDEMIOLOGY AND ENVENOMATION; South Asia; Africa; Europe; Americas; Australia; CONCLUSION; REFERENCES; Chapter 2: VENOMS FROM "NON-VENOMOUS" SNAKES: REAR-FANGED SNAKE VENOMS AS SOURCES OF NOVEL COMPOUNDS; ABSTRACT; INTRODUCTION

BIOLOGY OF REAR-FANGED SNAKES: ITS RELEVANCE TO TOXINOLOGISTSDiversity; Gland Structure - The Duvernoy's Venom Gland; Venom Yields; COMPOSITION OF VENOM FROM REAR-FANGED SNAKES; Analysis of Venoms; Mass Spectrometry, Proteomic Analysis and Transcriptomic Analyses ofRear-Fanged Snake Venoms; Enzymes; PIII Metalloprotease; Matrix Metalloproteinase; Serine Proteinase; Acetylcholinesterase (AChE); Phospholipase A2; Non-Enzymatic Toxins; Cysteine-Rich Secretory Proteins (CRiSPs); Three-Finger Toxins; Other Components; DRUG DEVELOPMENT POTENTIAL; CONCLUSION AND FUTURE DIRECTIONS; REFERENCES

Chapter 3: VENOM PRODUCTION IN THE 21ST CENTURYABSTRACT; INTRODUCTION; LEGAL CONSIDERATIONS; SAFETY; HUSBANDRY; Biology of the Animals; New Specimens; Feeding; Disease Control; Cleaning/Disinfecting; Record Keeping; Breeding; EXTRACTIONS; REFERENCES; SECTION TWO: CLINICAL AND PATHOPHYSIOLOGICAL ASPECTS; Chapter 4: EXTENDING THE USE OF SNAKE VENOMS TO THERAPEUTICS; ABSTRACT; INTRODUCTION; HISTORICAL USE; DRUG QUALITY; DRUG ENGINEERING; ROUTE OF ADMINISTRATION OPTIONS; PRODUCT PROTECTION STRATEGIES; Patent Term Extensions; Orphan Drug Status

New Chemical/Molecular Entities (NCE/NME) Market ExclusivityBiologic Exclusivity; PRECLINICAL ANIMAL STUDIES; REGULATORY STRATEGY; CLINICAL TRIALS; CONCLUSION; REFERENCES; Chapter 5: PATHOPHYSIOLOGICAL SIGNIFICANCE AND THERAPEUTIC IMPLICATIONS OF RUSSELL'S VIPER VENOM PROTEINS AND PEPTIDES AFFECTING BLOOD COAGULATION; ABSTRACT; INTRODUCTION; HEMOSTATICALLY ACTIVE PROTEINS AND PEPTIDES FROM RVV; Procoagulant Proteins Isolated from RVV: Structure-Functional Propertiesand Mechanisms of Action; Factor X Activators; Factor V Activators; Thrombin-Like Enzymes; Prothrombin Activators

Anticoagulant Proteins from RVV: Structure-Functional Properties andMechanisms of ActionAnticoagulant Proteins Possessing Enzymatic Activity; Phospholipase A2 (PLA2) Enzymes; Fibrino(geno)lytic Proteases; Non-Enzymatic Anticoagulant Proteins/Peptides; Kunitz-Type Serine Protease Inhibitors; C-Type Lectin Like Proteins; An Apoptosis-Inducing Anticoagulant Peptide; Pharmacological Properties and Toxicity of Procoagulant and Anticoagulant Proteins/Peptides Purified from RVV; Biomedical Applications of RVV Proteins/Peptides Affecting Hemostasis; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES

Chapter 6: VENOM PEPTIDE ANTAGONISTS OF THE NICOTINIC ACETYLCHOLINE RECEPTOR DO NOT PREVENT FATAL ENCEPHALITIS IN THE HAMSTER MODEL OF RABIES

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

1-63484-774-1

OCLC:

949912272