Biochemistry and molecular biology : the complexity of human traits and diseases / Mary Miu Yee Waye, editor.

Format:

Book

Contributor:

Yee Waye, Mary Miu, editor.

Series:

Biochemistry research trends series.

Biochemistry Research Trends

Language:

English

Subjects (All):

Molecular biology--Research.

Molecular biology.

Biochemistry--Data processing.

Biochemistry.

Physical Description:

1 online resource (161 p.)

Place of Publication:

New York, New York : Nova Science Publishers, Inc., 2015.

Language Note:

English

Summary:

Even though the ApoA5 gene was discovered more than 13 years ago by Pennacchio et al, 2001 [1], and it was known then the gene influences triglycerides, leading to speculations that it would affect the risk of stroke; the factors that affect cardiovascular diseases are very complex. Larry Baum's group shown that APOA5 genotypes were not significantly associated with strokes or stroke subtypes in the cohort they studied [2]. The discovery of the ApoA5 gene was very special in that, unlike many other genes discovered through studying a known protein or enzyme, advanced bioinformatics was used for the initial gene discovery, an amazing feat that could not have been done without knowledge of the human genome. The laborious effort in deciphering the genome was very controversial in its infancy, and voices of opposition nearly led to premature abortion of the project, and much of the objection was voiced due to the doubt of spending a hugh budget in sequencing what was thought to be useless, i.e. for a major proportion (98%) of junk DNA at that time. However, recently it was shown that deleting a non-coding region of what was thought to be junk DNA could lead to narrowing of arteries in mice [3] so that might offer an explanation that there are more to the story of stroke risk factors than merely studying APOA5, and such findings just remind us time and again, often the basic research could laid the foundation that is very essential for discoveries made by clinicians or the translational/applied scientists.

Contents:

""BIOCHEMISTRY AND MOLECULAR BIOLOGY: THE COMPLEXITY OF HUMAN TRAITS AND DISEASES""; ""BIOCHEMISTRY AND MOLECULAR BIOLOGY: THE COMPLEXITY OF HUMAN TRAITS AND DISEASES""; ""Library of Congress Cataloging-in-Publication Data""; ""Contents""; ""Introduction""; ""References""; ""Chapter 1: Apolipoprotein A5 Polymorphism and Triglycerides in Ischemic Cerebrovascular Disease""; ""Abstract""; ""Abbreviations""; ""Introduction""; ""Methods""; ""Patients""; ""Etiology""; ""Controls""; ""Genotyping""; ""Statistics""; ""Results""; ""Conclusion""; ""References""

""Chapter 2: Expression of the Dyslexia Candidate Gene kiaa0319-Like in Insect Cells""""Abstract""; ""Main Text""; ""Acknowledgments""; ""References""; ""Chapter 3: The Lipoprotein Lipase 447Ter Variant Is Not Associated with Age-related Macular Degeneration in Chinese""; ""Abstract""; ""Introduction""; ""Methods""; ""Results and Discussion""; ""References""; ""Chapter 4: A Case-Control Study of Association between Brain-Derived Neurotrophic Factor 712G>A Polymorphism and Parkinson�s Disease""; ""Abstract""; ""Introduction""; ""Materials and Methods""; ""Results""; ""Discussion""

""References""""Chapter 5: A 1.36-Megabase Deletion in Chromosome 18q21.32 Including GRP in a Patient with Epilepsy, Borderline Intellectual Disability, and Multiple Cerebral Cavernous Malformations""; ""Abstract""; ""Introduction""; ""Methods""; ""Results""; ""Discussion""; ""Acknowledgments""; ""References""; ""Reviews""; ""Chapter 6: Analysis of Codon Bias and Its Application on the Expression of Foreign Genes in Fungi""; ""Abstract""; ""Introduction""; ""Basic Theories and Analysis Methods about Codon Bias""; ""Relative Synonymous Codon Usage (RSCU)""; ""Codon Adaptation Index (CAI)""

""Effective Number of Codons (ENC or Nc) [12, 13]""""Codon Preference Parameter (CPP) [16]""; ""Frequency of Optimal Codons (FOP) [17]""; ""Codon Bias Index (CBI) [18]""; ""Relative Frequency of Synonymous Codons (RFSC)""; ""Relative Codon Adaptation (RCA) [22]""; ""Codon Deviation Coefficient (CDC) [23]""; ""The Application of Codon Bias Analyses on Foreign Genes Expression in Fungi""; ""The Application in Yeasts""; ""The Application in Molds""; ""The Application in Mushrooms""; ""References""; ""Chapter 7: The Blood-Brain Barrier Roadblock: Strategies for Targeted Drug Delivery""

""Abstract""""Introduction""; ""Methods""; ""Direct Injection""; ""Ultrasound""; ""Cell Penetrating Peptides""; ""Nanoparticles""; ""Conclusion""; ""Acknowledgment""; ""References""; ""Chapter 8: Genetics and Epigenetics of Bipolar Disorder""; ""Abstract""; ""List of Abbreviations""; ""Introduction""; ""Major Symptoms of Bipolar Disorder""; ""Subtypes of Bipolar Disorders""; ""Prevalence and Age of Onset""; ""Personal and Social-Economic Impacts""; ""High Heritability of Bipolar Disorder""; ""Approaches in Searching for Candidate Genes Related to Susceptibility of Bipolar Disorder""

""Family-Based Studies and Twin Studies""

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on online resource; title from PDF title page (ebrary, viewed May 16, 2015).

ISBN:

1-63482-313-3