Ribavirin : biochemistry, clinical applications and potential side effects / Joris Buskirk, editor.

Format:

Book

Contributor:

Buskirk, Joris.

Series:

Pharmacology-research, safety testing, and regulation series.

Pharmacology-research, safety testing and regulation

Language:

English

Subjects (All):

Ribavirin.

Antiviral agents.

Physical Description:

1 online resource (122 p.)

Place of Publication:

Hauppauge, NY : Nova Science Publishers, Inc., [2013]

Language Note:

English

Summary:

Ribavirin has been studied for over 20 years as a potential therapy against a number of RNA and DNA viruses. It is well known that Ribavirin in combination with Interferon is a key antiviral component in the treatment of Hepatitis C virus infection. In this book, the authors discuss the biochemistry, clinical applications and potential side effects of Ribavirin. Topics include optimizing Ribavirin use for the treatment of Hepatitis C; Ribavirin and its great potential in infectious diseases; the antiviral actions of Ribavirin; a novel prediction method for the responsiveness of Hepatitis C pat

Contents:

""RIBAVIRIN. BIOCHEMISTRY, CLINICAL APPLICATIONS AND POTENTIAL SIDE EFFECTS""; ""RIBAVIRIN. BIOCHEMISTRY, CLINICAL APPLICATIONS AND POTENTIAL SIDE EFFECTS""; ""Library of Congress Cataloging-in-Publication Data""; ""Contents""; ""Preface""; ""Chapter 1: Optimizing Ribavirin Usefor the Treatment of Hepatitis C""; ""Abstract""; ""Introduction""; ""Hepatitis C (HCV)""; ""The Evolution of HCV Treatment -The Importance of RBV""; ""Why Was New Treatment Discovery for HCV Hampered?""; ""The Direct Acting Antiviral (DAA) Era""; ""Pharmacokinetics of RBV""; ""RBV �Induced Hemolytic Anemia""

""Identification of the Inosine Triphosphatase Gene""""Mechanism of Action of Ribavirin in HCV""; ""The Importance of RBV Adherence""; ""The Importance of Pill Burden and Dosing Frequency on Medication Adherence""; ""RBV QD vs. BID Dosing""; ""Summary of Once Daily DAA trials""; ""Conclusion""; ""References""; ""Chapter 2: Ribavirin and its Great Potentials in Infectious Diseases""; ""Abstract""; ""Introduction""; ""Structure""; ""History""; ""Metabolism""; ""Mechanism of Action""; ""Spectrum of Action""; ""Anticancer Role""; ""Ribavirin Derivatives""; ""Ribavirin and HCV""

""Ribavirin Side Effects""""References""; ""Chapter 3: Antiviral Actions of Ribavirin""; ""Abstract""; ""Introduction""; ""1. Biochemistry, Pharmacokinetics and Mechanism of Action""; ""2. Clinical Applications""; ""3. Potential Side Effects""; ""References""; ""Chapter 4: A Novel Prediction Method for the Responsiveness of Hepatitis C Patients to Drug Treatment""; ""Abstract""; ""1. Introduction""; ""2. Materials and Methods""; ""3. Results and discussion""; ""Acknowledgments""; ""References""

""Chapter 5: Ribavirin Intolerable Cough during HCV Combination Therapy Can Be Overcome by Nitazoxanide Replacement""""Abstract""; ""Introduction""; ""Case Presentation""; ""Discussion""; ""Conclusion""; ""References""; ""Index""

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-62808-814-1

OCLC:

862134874