Epigenetics : mechanisms and clinical perspectives / Yildiz Dincer, editor.

Format:

Book

Contributor:

Dincer, Yildiz, editor.

Series:

Genetics--research and issues series.

Genetics - Research and Issues

Language:

English

Subjects (All):

Genetic regulation.

Epigenetics.

Epigenesis, Genetic.

Medical Subjects:

Epigenesis, Genetic.

Physical Description:

1 online resource (266 p.)

Place of Publication:

New York, [New York] : Nova Biomedical, 2016.

Language Note:

English

Summary:

Epigenetics is a relatively new field of science explaining heritable changes that are not caused by alterations in DNA sequences. Epigenetic modifications are acquired throughout life, and depend on environmental clues such as diet, lifestyle and toxin exposure. It is possible to pass down epigenetic modifications to the next generation of offspring if the modifications occur in sperm or egg cells. Additionally, epigenetic regulations are central to many cellular processes such as imprinting, X chromosome inactivation, DNA damage response, cellular reprogramming and senescence. This book provides an overview for the influence of early life nutrition on the epigenome and the role of epigenetic dysregulations in the pathogenesis of many common diseases.

Contents:

EPIGENETICS MECHANISMS AND CLINICAL PERSPECTIVES; EPIGENETICS MECHANISMS AND CLINICAL PERSPECTIVES; CONTENTS; PREFACE ; Chapter 1 EPIGENETIC MODIFICATIONS AND DEVELOPMENTAL ORIGIN OF HEALTH AND DISEASES (DOHAD) ; Abstract; Abbreviations; 1. Introduction; 2. What Is Epigenetics?; 2.1. DNA Methylation; 2.2. MicroRNAs; 3. Evidence from Human Cohorts; 3.1. Fetal Programming Hypothesis; 3.2. DNA Methylation and Fetal Programming Hypothesis; 3.3. MicroRNAs and Fetal Programming Hypothesis; 4. Evidence from Animal Experiments; 4.1. DNA Methylation and Animal Experiments

4.1.1. Maternal Nutrition4.1.2. Paternal Nutrition; 4.2. MicroRNAs and Animal Experiments; 4.2.1. Maternal Nutrition; 4.2.2. Paternal Nutrition; 5. Developmental Plasticity and Reversibility; Conclusion and Further Perspective; References; Chapter 2 EFFECTS OF OXIDATIVE STRESS ON EPIGENETIC MECHANISMS ; Abstract; Abbreviations; 1. Epigenetic Mechanisms; 1.1. DNA Methylation; 1.2. Histone Post-translational Modifications; 1.3. Micro RNAs and Epigenetic; 2. Oxidative Stress; 3. Interactions between Oxidative Stress and Epigenetic Mechanisms; 3.1. Oxidative Stress - DNA Methylation

3.2. Oxidative Stress - Histone Post-Translational Modifications3.3. Oxidative Stress - miRNAs; Conclusion; References; Chapter 3 EPIGENETIC MODIFICATIONS AND THEIR POTENTIAL ROLE IN TUMORIGENESIS ; Abstract; Abbreviations; 1. Introduction; 2. The Dysregulation of Epigenetic Factors in Various Cancers; 2.1. The Deregulation of DNA Methylation in Cancer; 2.2. The Deregulation of Histone Lysine Methylation in Cancer; 2.3. The Deregulation of Histone Lysine Demethylases in Cancer; 3. Histone Lysine Acetylation in Cancer

3.1. The Deregulation of Histone Lysine Acetyltransferases in Tumor Proliferation and Metastasis3.2. The Deregulation of Histone Lysine Deacetylases (KDACs) in Cancer; 4. Histone Acetylation "Code" as a Diagnostic Marker for Cancer Progression; 5. Epigenetic Modifications in Oncogenes and Tumor Suppressor Genes; 6. Epigenetic Modifications in Cellular Signaling Pathways; 6.1. NF-(B Signaling Pathway; 6.2. STAT3 Signaling Cascade; 6.3. Wnt/(-Catenin Signaling Pathway; 7. Epigenetic Modification in Cancer Stem Cells

8. Epigenetic Modifications Associated with Cancer Chemo- and Radio-Resistance9. Pharmacological Inhibitors of Epigenetic Modifications; Perspectives and Conclusion; Acknowledgments; Conflict of Interest Statement; References; Chapter 4 ALZHEIMER'S DISEASE: AN INSIGHT FROM EPIGENETIC PERSPECTIVE ; Abstract; Abbreviations; 1. Introduction; 2. Pathogenesis of Alzheimer's Disease; 2.1. Aβ Hypothesis; 2.2. Tau Hypothesis; 2.3. Oxidative Stress in Alzheimer's Disease; 2.4. Metal Dyshomeostasis in Alzheimer's Disease; 2.5. Mitochondrial Dysfunction in Alzheimer's Disease

2.6. Neuroinflammation in Alzheimer's Disease

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

1-63484-519-6