Lymphatic filariasis / edited by Thomas B. Nutman.

Format:

Book

Contributor:

Nutman, Thomas B.

Series:

Tropical medicine ; v. 1.

Tropical medicine ; v. 1

Language:

English

Subjects (All):

Filariasis.

Helminthiasis.

Physical Description:

1 online resource (293 p.)

Place of Publication:

London : Imperial College Press ; River Edge, NJ : Distributed by World Scientific Pub., c2000.

Language Note:

English

Summary:

This is the first in a series dedicated to the understanding of tropical diseases. This volume examines the basic biology and clinical expression of lymphatic-dwelling filarial parasites, parasites affecting over 128 million people in the tropical and subtropical regions of the world. Although it is responsible for the disfiguring elephantiasis, infection with this parasite leads to a spectrum of clinical manifestations. The underlying pathogenetic mechanisms of infection, its epidemiology, diagnosis, treatment and prevention of this often devastating vector-borne diseases will be the focus of

Contents:

Preface; Contents; Chapter 1 Lymphatic Filariasis: A Historical Perspective; References; Chapter 2 Lymphatic-dwelling Filariae; The Infectious Agent; Lymphatic Filariasis; Biology/Life Cycle; Development in the Mosquito; Development in the Human; Animal Models; Phylogeny of the Lymphatic Filariae; Structure/Anatomy; Surface Coat/Epicuticle/Cuticle; Sheath; Hypodermis/Lateral Chord; Muscles; Pseudocoelom; Digestive System; Reproductive System; Male; Female; Reproductive Biology; Spermatogenesis; Oogenesis; Embryogenesis; Molecular Development; Filarial Genome; Gene Transcription

Post-translational Addition of PhosphorylcholineExcretory/Secretory Products; References; Chapter 3 The Population Dynamics and Epidemiology of Lymphatic Filariasis; Introduction; Epidemiology of Infection; Dynamics of Infection Prevalence; Age-intensity Data; Dynamics of Disease; Relationship Between Infection and Disease; Loss of infection and disease development; The impact of neonatal tolerance; The Roles of 'Acute' Disease and Asymptomatic Lymphatic Pathology; Control; Conclusion; References; Chapter 4 Resistance to Infection with Lymphatic-dwelling Filarial Parasites; Introduction

Evidence for Resistance to Lymphatic-dwelling Filariae in HumansComplexity of Evaluating Resistance in Human Lymphatic Filariasis; Quantification of Infection Burden in Humans; Evaluation of Infection Status with the Use of Assays thatDetect Circulating Parasite Antigens; Operative Definition of Resistance to Lymphatic-dwellingFilariae; Epidemiologic Evidence for Acquired Resistance toInfection in Humans; Immunologic Correlates of Acquired Resistancein Humans; Immunologic Correlates of Protective Immunity in Humans

Possible Contribution of Immunologic Tolerance to Susceptibilityto Infection and MicrofilaraemiaDefined Antigens Associated with Protective Immunityin Humans; Conclusions and Future Directions; References; Chapter 5 The Clinical Manifestations ofLymphatic Filariasis; Clinical Manifestations; The Microfilaraemic Stage; Acute Manifestations of Lympatic Filariasis; Acute Filarial Lymphangitis (AFL); Acute attack secondary bacterial or fungal infection: reticularlymphangitis; The role of bacterial and fungal infections in ADL attacks; The Course of Acute Attacks

Chronic Manifestations of Lymphatic FilariasisMale Genital Disease: (seen only in bancroftian filariasis); Lymphoedema of the Genitalia; Lymphorrhea; Chyluria; Tropical Pulmonary Eosinophilia; Filarial Granulomata; Adenopathy; The ""Endemic Normal""; Clinical Manifestations in Expatriates and Transmigrants; Other Syndromes of Uncertain Relation to Filariasis; Differentiation from other Syndromes; Clinical Manifestations of Adverse Reactions to Treatment; Socioeconomic Aspects of Lymphatic Filariasis; References; Chapter 6 Diagnosis of Lymphatic Filarial Infections; Introduction

Indications for Diagnostic Evaluation

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9781848160866

1848160860