Structural proteomics and its impact on the life sciences / Joel L. Sussman, Israel Silman, editors.

Format:

Book

Contributor:

Sussman, Joel.

Silman, Israel.

Language:

English

Subjects (All):

Proteomics.

Proteins--Structure.

Proteins.

Physical Description:

1 online resource (600 p.)

Place of Publication:

Hackensack, N.J. : World Scientific, c2008.

Language Note:

English

Summary:

The role played by structural proteomics in the first decade of the 21st century is equivalent to that played by the Human Genome Project in the last decade of the 20th century. The development of high-throughput technologies that permit the solution of hundreds of 3D structures of individual proteins, protein-protein complexes and protein-drug complexes, just by one laboratory in a single year, will provide a knowledge base which will change the face of structural biology. This will have an immediate influence on medicinal chemistry and molecular pharmacology, as well as an increasing impact

Contents:

ch. 1. The importance of target selection strategies in structural biology / Enrique E. Abola and Raymond C. Stevens

ch. 2. The impact of structural proteomics on macromolecular structure databases / James D. Watson and Janet M. Thornton

ch. 3. The impact of 3D structures on a protein knowledgebase: from proteins to systems / Ursula Hinz and Amos Bairoch

ch. 4. Bioinformatics of protein function / Arthur M. Lesk ... [et al.]

ch. 5. Comparative modeling in structural genomics / John Moult

ch. 6. The contribution of structural proteomics to understanding the function of hypothetical proteins / Michael D. Suits ... [et al.]

ch. 7. Intrinsically disordered proteins / Peter Tompa

ch. 8. Metalloproteins: structure, conservation and prediction of metal binding sites / Marvin Edelman ... [et al.]

ch. 9. The impact of protein expression methodologies on structural proteomics / A. Chesneau, H. Yumerefendi and D. J. Hart

ch. 10. Protein complexes assembly by multi-expression in bacterial and eukaryotic hosts / Christophe Romier

ch. 11. The impact of structural proteomics on the prediction of protein-protein interactions / Christina Kiel and Luis Serrano

ch. 12. Cryo-electron microscopy in the era of structural proteomics / Alasdair C. Steven and David M. Belnap

ch. 13. On NMR-based structural proteomics / Thomas Szyperski

ch. 14. Structural proteomics in relation to signaling pathways / Florence Bedez, Arnaud Poterszman and Dino Moras

ch. 15. The impact of structural proteomics on drug design / Yuan-Ping Pang

ch. 16. Structural proteomics of emerging viruses: the examples of SARS-CoV and other coronaviruses / Rolf Hilgenfeld ... [et al.]

ch. 17. High-throughput technologies for structural biology: the protein structure initiative perspective / Andrzej Joachimiak

ch. 18. European structural proteomics - a perspective / Susan Daenke, E. Yvonne Jones and David I. Stuart

ch. 19. Structural genomics and structural proteomics: a global perspective / Lucia Banci ... [et al.]

ch. 20. Policies in structural genomics/structural proteomics. A. The protein structure initiative: policies and update / John Norvell and Jeremy Berg. B. Structural genomics in European framework programs / Josefina Enfedaque, Sa�sa Jenko Kokalj and Jacques Remacle. C. Policy aspects in structural genomics/proteomics / Barbara Skene. D. Policies and updates of the RIKEN structural genomics/proteomics initiative / Shigeyuki Yokoyama. E. The international structural genomics organization: policies for structural genomics / Thomas C Terwilliger ... [et al.].

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786611911904

9781281911902

1281911909

9789812772053

9812772057