Bile duct cancer : symptoms, treatment and prognosis / Donna E. Matthews, editor.

Format:

Book

Contributor:

Matthews, Donna E., editor.

Series:

Cancer etiology, diagnosis, and treatments.

Cancer Etiology, Diagnosis and Treatments

Language:

English

Subjects (All):

Bile ducts--Magnetic resonance imaging.

Bile ducts.

Bile ducts--Cancer.

Physical Description:

1 online resource (104 p.)

Place of Publication:

New York : Nova Biomedical, 2016.

Summary:

Primary bile duct cancers are rare and generally aggressive entities. Historically, this disease was managed exclusively with surgical therapy with few long-term survivors. However, with improvements in chemotherapeutics, targeted therapy, interventional radiology techniques and development of alternative surgical approaches, treatment has moved to the utilization of a multidisciplinary care team employing multimodality treatments which has finally led to improvement in outcomes. In this book, Chapter One examines symptoms and the current state of medical and surgical management of bile duct cancer, while Chapter Two discusses the clinical aspects of care of extrahepatic biliary cancers with an emphasis on diagnosis and management. Chapter Three assesses the risk of bile duct cancer among beneficiaries of The Health Insurance Society of Printing Industry (HISPI) using diagnosis-procedure-combination (DPC) data in comparison with general population. Chapter Four concludes with a summary of results for chemotherapy and targeted therapies.

Contents:

BILE DUCT CANCER SYMPTOMS, TREATMENT AND PROGNOSIS ; BILE DUCT CANCER SYMPTOMS, TREATMENT AND PROGNOSIS ; CONTENTS ; PREFACE; Chapter 1 CHOLANGIOCARCINOMA: SYMPTOMS AND CURRENT STATE OF MEDICAL AND SURGICAL MANAGEMENT ; ABSTRACT; INTRODUCTION; SYMPTOMS ; TREATMENT; INTRAHEPATIC CHOLANGIOCARCINOMA ; HILAR CHOLANGIOCARCINOMA AND EXTRAHEPATIC CHOLANGIOCARCINOMA ; PROGNOSIS ; REFERENCES ; Chapter 2 EXTRA HEPATIC CHOLANGIOCARCINOMA: SYMPTOMS, TREATMENT AND PROGNOSIS ; ABSTRACT ; EPIDEMIOLOGY ; RISK FACTORS ; CLINICAL PRESENTATION ; DIAGNOSTIC WORK-UP ; ANATOMY

LABORATORY INVESTIGATIONS IMAGING ; Ultrasound (US) ; Computed Tomography (CT)/Multi-Detector Computed Tomography (MDCT) ; Magnetic Resonance Imaging (MRI) ; Endoscopic Retrograde Cholangiopancreatography (ERCP)/Percutaneous Transhepatic Cholangiography (PTC) ; Endoscopic Ultrasonography (EUS)/Intraductal Ultrasonography (IDUS) ; Positron Emission Tomography (PET) ; Biopsy ; Staging ; Treatment; Distal Cholangiocarcinoma ; Perihilar Cholangiocarcinoma ; Preoperative Liver Evaluation/Interventions ; TREATMENT OF BILIARY OBSTRUCTION ; Adjuvant Therapies

Neoadjuvant Therapy and Transplantation Palliative Treatment ; REFERENCES ; Chapter 3 PREVALENCE OF BILE DUCT CANCER AS MEASURED BY DISCHARGES FROM DIAGNOSIS-PROCEDURE-COMBINATION (DPC) PARTICIPATING HOSPITALS AMONG BENEFICIARIES OF A PRINTING INDUSTRY HEALTH INSURANCE SOCIETY IN COMPARISON WITH GENERAL POPULATION ; ABSTRACT ; INTRODUCTION ; SUBJECTS AND METHODS ; 1. DPC Data from General Population ; 2. DPC data from HISPI; 3. Analysis ; 4. Ethical Approval ; RESULTS ; DISCUSSION ; ACKNOWLEDGMENTS ; REFERENCES ; Chapter 4 MEDICAL TREATMENT OF ADVANCED BILIARY TRACT CANCER ; ABSTRACT

1.1. INTRODUCTION 1.2. CHEMOTHERAPY IN ADVANCED BILIARY TRACT CANCER ; 1.2.1. Combinations of Gemcitabine and Platinum Derivatives ; 1.2.2. Combinations of Gemcitabine and Fluoropyrimidines ; 1.2.3. Triple-Drug Chemotherapy Regimens; 1.2.4. S-1 Based Combinations ; 1.2.5. Second-Line Chemotherapy ; 1.3 TARGETED THERAPIES IN ADVANCED BILIARY DUCT CANCER ; 1.3.1. Therapies Targeting EGFR Pathway ; 1.3.1.1. Erlotinib; 1.3.1.2. Cetuximab ; 1.3.1.3. Panitumumab; 1.3.1.4. Afatinib ; 1.3.2. Therapies Targeting the VEGF Pathway ; 1.3.2.1. Bevacizumab ; 1.3.2.2. Sunitinib ; 1.3.2.3. Cediranib

1.3.2.4. Sorafenib1.4. IMMUNOTHERAPY IN BILIARY TRACT CANCER ; 1.4.1. Tumor-Associated-Antigens ; 1.4.2. Checkpoint Inhibitors ; 1.4.3. How Can We Explain an Enhanced Immune Response in Biliary Cancers? ; CONCLUSION ; REFERENCES ; BIOGRAPHICAL SKETCH ; INDEX

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

1-63484-724-5