Perfluorooctanoic acid (PFOA) : global occurrence, exposure, and health effects / Eva Hampton, editor.

Format:

Book

Contributor:

Hampton, Eva, editor.

Series:

Biochemistry research trends series.

Biochemistry Research Trends

Language:

English

Subjects (All):

Fluorocarbons--Environmental aspects.

Fluorocarbons.

Fluorocarbons--Toxicology.

Perfluorooctanoic acid--Environmental aspects.

Perfluorooctanoic acid.

Perfluorooctanoic acid--Toxicology.

Physical Description:

1 online resource (164 p.)

Place of Publication:

New York, [New York] : Nova Science Publishers, 2016.

Language Note:

English

Summary:

Perfluorinated compounds (PFCs) are a group of organofluorine, aliphatic hydrocarbons, of which all or almost all hydrogen atoms are replaced with fluorine. They have a wide range of industrial and consumer applications such as stain, paints, hydraulic fluids, firefighting foams, production of fluoropolimers, cosmetics, insecticide formulations, textile treatments, surface coatings for carpets and furniture, cookware and water- and oil- resistant coatings for food contact materials. PFCs are extremely resistant towards thermal, chemical and biological degradation processes. There is now no evidence for their degradability and they decompose only at very high temperatures using a specially prepared furnaces. The authors of this book summarise the recent information on the occurrence, exposure and health effects caused by perfluorooctanoic acid (PFOA).

Contents:

PERFLUOROOCTANOIC ACID (PFOA) GLOBAL OCCURRENCE, EXPOSURE AND HEALTH EFFECTS ; PERFLUOROOCTANOIC ACID (PFOA) GLOBAL OCCURRENCE, EXPOSURE AND HEALTH EFFECTS ; CONTENTS ; PREFACE ; Chapter 1 PERFLUOROOCTANOIC ACID (PFOA) AND PERFLUOROOCTANE SULFONATE (PFOS): GLOBAL OCCURRENCE, EXPOSURE AND HEALTH EFFECTS ; ABSTRACT ; CHEMICAL STRUCTURE AND PROPERTIES OF PFOA AND PFOS ; PFOA AND PFOS PRODUCTION NAD APPLICATION; OCCURRENCE AND HUMAN EXPOSUURE FOR PFOA AND PFOS; HEPATIC EFFECTS OF PFOA AND PFOS ; NEUROTOXIC EFFECTS OF PFOA AND PFOS ; IMMUNOTOXICITY OF PFOA AND PFOS

REPRODUCTIVE TOXICITY OF PFOA AND PFOS CURRENT EU LEGISLATION ; REFERENCES ; Chapter 2 IN VITRO STUDY OF THE EXPOSITION OF HUMAN MYOFIBROBLASTS OF COLON CCD-18CO TO PERFLUOROOCTANOIC ACID (PFOA) ; ABSTRACT; INTRODUCTION ; METHODS ; Material and Reagents ; Cell Line, Culture Conditions and Treatment ; Cell Viability and Proliferation Rate Assayed by Trypan Blue Dye Exclusion ; Determination of the Concentration of PFOA in Culture Medium by LC-MS QqQ ; RESULTS ; Cytotoxicity and Proliferation Rate; Effect of PFOA on the Shape of Myofibroblats CCD-18Co

Quantification of PFOA in Culture MediumStatistical Analysis; CONCLUSION ; ACKNOWLEDGMENT ; REFERENCES ; Chapter 3 LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY IN THE ANALYSIS OF PERFLUOROOCTANOIC ACID (PFOA): OCCURRENCE IN FOOD ; ABSTRACT ; 1. INTRODUCTION ; 2. LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY ; 3. HIGH RESOLUTION MASS SPECTROMETRY ; 4. OCCURRENCE OF PFOA IN FOOD ; CONCLUSION ; ABBREVIATIONS; ACKNOWLEDGMENTS ; REFERENCES ; Chapter 4 CHROMATOGRAPHIC DETERMINATION OF PFOA, OTHER SELECTED PERFLUORINATED ORGANIC COMPOUNDS, AND TOTAL ORGANIC FLUORINE IN NATURAL WATERS AND MILK SAMPLES

ABSTRACT INTRODUCTION ; METHODS ; Reagents and Materials ; Apparatus ; Procedures; Sample Preparation ; RESULTS AND DISCUSSION ; Analysis of Natural Water Samples ; Analysis of Milk Samples ; CONCLUSION ; REFERENCES ; Chapter 5 SERUM PERFLUOROALKYL ACIDS CONCENTRATIONS, T-HELPER CELL-SPECIFIC CYTOKINES, AND ASTHMA OUTCOMES IN A CASE-CONTROL STUDY OF CHILDREN ; ABSTRACT ; INTRODUCTION ; METHODS ; Participants ; Serum TH Cytokines and IgE Level Detection ; Serum PFC Concentrations ; Standards and Reagents ; Sample Preparation and Extraction ; Instrumental Analysis

Quality Assurance and Quality Control Statistical Analysis ; RESULTS ; DISCUSSION ; CONCLUSION ; REFERENCES ; BIOGRAPHICAL SKETCH ; INDEX ; Blank Page

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-63484-913-2