The carcinogenic effects of polycyclic aromatic hydrocarbons / editor, Andreas Luch.

Format:

Book

Contributor:

Luch, Andreas.

Language:

English

Subjects (All):

Chemical carcinogenesis.

Genetic toxicology.

Polycyclic aromatic hydrocarbons--Carcinogenicity.

Polycyclic aromatic hydrocarbons.

Polycyclic aromatic hydrocarbons--Toxicology.

Physical Description:

1 online resource (514 p.)

Place of Publication:

London : Imperial College Press ; Singapore ; Hackensack, NJ : Distributed by World Scientific Pub., c2005.

Language Note:

English

Summary:

This book provides an overview on the molecular mode of action of carcinogenic polycyclic aromatic hydrocarbons (PAHs). PAHs are by-products arising from incomplete combustion of organic matter that are frequently released into our environment, and thus are ubiquitously detectable. Many PAHs are strong carcinogens in rodent bioassays and have been linked to increased incidences of various types of cancer in humans. The present book covers all aspects of PAH-induced carcinogenesis; it is a collection of articles written by some of the most recognizable PAH researchers, reviewing the present kno

Contents:

Preface; In Memoriam: Anthony Dipple (1940-1999); List of Contributors; Contents; 1 Polycyclic Aromatic Hydrocarbon-Induced Carcinogenesis - An Introduction; 2 Metabolic Activation and Detoxification of Polycyclic Aromatic Hydrocarbons; 2.1 Introduction; 2.2 Structure-Activity Relationships; 2.3 Enzymatic Activation; 2.3.1 Monooxygenation and Dihydrodiol Epoxide Pathway; 2.3.2 Stereochemistry of Activation; 2.3.3 One-Electron Oxidation; 2.3.4 Formation of Quinones; 2.3.5 'Bioalkylation' and Benzylic Ester Pathway; 2.4 Detoxification; 2.5 Summary and Perspectives

3 Biomonitoring of Polycyclic Aromatic Hydrocarbons - Human Exposure3.1 Introduction; 3.2 Studies at Work Places/Occupational Exposure to PAHs; 3.3 Non-Occupational Exposure to PAHs; 3.4 Metabolism and Excretion of PAHs; 3.5 Biomonitoring of PAHs and Their Metabolites; 3.5.1 Principal Considerations; 3.5.2 1-Hydroxypyrene and Its Glucuronide; 3.5.3 Enzyme Polymorphisms and Excretion Levels of 1-Hydroxypyrene; 3.5.4 Phenanthrene Metabolites; 3.5.5 Benzo[a]pyrene Metabolites; 3.6 Summary; 3.7 Conclusions

4 Macromolecular Adducts as Biomarkers of Human Exposure to Polycyclic Aromatic Hydrocarbons4.1 Introduction; 4.2 Methods of Detection; 4.3 Occupational Exposure to PAHs; 4.3.1 Iron and Steel Production; 4.3.2 Aluminum Production; 4.3.3 Coke Ovens and Graphite Electrode Manufacture; 4.3.4 Other Occupational Exposures; 4.4 Environmental Exposure to PAHs; 4.5 Coal Tar Therapy; 4.6 Diet; 4.7 Discussion and Summary; 5 DNA Damage and Mutagenesis Induced by Polycyclic Aromatic Hydrocarbons; 5.1 Introduction; 5.2 Evolution of Research on PAHs; 5.3 Chemistry and Biological Effects

5.4 Significance of Stable versus Unstable PAH-DNA Adducts5.5 Mutagenicity of PAH-DNA Adducts; 5.5.1 Site-Specific Mutagenicity of PAH-DNA Adducts; 5.5.2 Translesional Synthesis; 5.6 Cancer Epidemiology and PAH-DNA Adducts; 5.6.1 Mapping of PAH-DNA Adducts; 5.6.2 Additional Evidence for the Etiological Relevance of PAHs in Human Carcinogenesis: The Exemplary Case of p53 Mutations in Lung Cancer; 5.7 Concluding Remarks; 6 Mechanisms of Repair of Polycyclic Aromatic Hydrocarbon-Induced DNA Damage; 6.1 Introduction; 6.2 Nucleotide Excision Repair; 6.2.1 Mammalian DNA Nucleotide Excision Repair

6.2.2 Subunits of the Human NER Machinery6.2.3 Transcription-Coupled DNA Repair; 6.2.4 Global NER Deficiency and Cancer; 6.3 Repair of PAH - DNA Adducts; 6.3.1 The In Vitro Oligonucleotide Excision Reaction; 6.3.2 Base Pair Conformation-Dependent Excision of B[a]PDE-dG Adducts; 6.3.3 Unrepaired Fjord-Region PAH-DNA Adducts in Ras Codon 61 Mutational Hotspots; 6.3.4 Bipartite Recognition of PAH-DNA Adducts; 6.3.5 Modulation of Human NER Activity by 5-Methylcytosines; 6.3.6 Antagonistic Interaction of NER Factors between Substrate and Decoy DNA Adducts

6.3.7 Mechanism of PAH Adduct Recognition by the Human NER Machinery

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786611866990

9781281866998

1281866997

9781860949333

1860949339