Progenitor cells : biology, characterization and potential clinical applications / Patrick M. Horton and Brett E. Lawrence, editors.

Format:

Book

Contributor:

Horton, Patrick M.

Lawrence, Brett E.

Series:

Cell Biology Research Progress

Cell biology research progress

Language:

English

Subjects (All):

Cells.

Stem cells.

Physical Description:

1 online resource (124 p.)

Place of Publication:

Hauppauge, New York : Nova Science Publishers, [2013]

Language Note:

English

Summary:

In this book, the authors present current research in the study of the biology, characterization and potential clinical application of progenitor cells. Topics discussed include endothelial progenitor cells and cardiovascular disease; isolation, expansion and clinical therapy of human corneal epithelial stem/progenitor cells; genetically engineered blood pharming; regulation of neural progenitor cells by Wnt5a-signaling in the developmental central nervous system; endothelial progenitor cells in a clinical setting; role of microRNAs in endothelial progenitor cells and their implication for car

Contents:

""PROGENITOR CELLS: BIOLOGY, CHARACTERIZATION AND POTENTIAL CLINICAL APPLICATIONS""; ""PROGENITOR CELLS: BIOLOGY, CHARACTERIZATION AND POTENTIAL CLINICAL APPLICATIONS""; ""Library of Congress Cataloging-in-Publication Data""; ""Contents""; ""Preface""; ""Chapter 1: Endothelial Progenitor Cells and Cardiovascular Disease""; ""Abstract""; ""1. Introduction""; ""2. Correlation between EPCs and Other Cardiovascular Risk Markers""; ""3. EPCs in Patients with Established Cardiovascular Disease""; ""4. Reversible Defects in EPC Number and Function in Patients with an Increased Cardiovascular Risk""

""5. Statins and EPC Biology""""6. The Effect on EPCs of Other Interventions Known to Reduce Cardiovascular Risk""; ""7. Beneficial Effects of Infusion of EPCs in Animal Models of Ischaemia""; ""8. Human Studies of EPC Administration""; ""Conclusion""; ""References""; ""Chapter 2: Characterization, Isolation, Expansion and Clinical Therapy of Human Corneal Epithelial Stem/Progenitor Cells""; ""Abstract""; ""Concept of Tissue Specific Adult Stem Cells and Progenitor Cells""; ""Human Corneal Epithelial Stem/Progenitor Cells""; ""The Phenotype of Corneal Epithelial Progenitor Cells""

""Isolation and Expansion of Corneal Epithelial Progenitor Cells""""Corneal Epithelial Stem Cell Deficiency""; ""Progenitor Cell Therapy and Tissue Engineering for Corneal Reconstruction""; ""Conclusion""; ""References""; ""Chapter 3: Genetically Engineered Blood Pharming: Generation of HLA Universal Platelets Derived from CD34+ Progenitor Cells""; ""Abstract""; ""Introduction""; ""Generation of Platelets In Vitro""; ""Platelet Transfusion Refractoriness""; ""Isolation and Culture of CD34+ Progenitor Cells""; ""Generation of HLA Universal Platelets""

""HLA-Universal Megakaryocytes Are Protected from Antibody-Mediated Complement-Dependent Cytotoxicity In Vitro""""HLA-Universal Megakaryocytes Increase Human PLT Counts in Mice Refractory to Human PLTS""; ""Conclusion""; ""References""; ""Chapter 4: Regulation of Neural Progenitor Cells by Wnt5a-Signaling in the Developmental Central Nervous System""; ""Abstract""; ""1. Introduction""; ""2. Wnt5a-Ror signaling in Neocortical NPCs""; ""3. Cooperative Function of Wnt5a signaling with Wnt/b-catenin Signaling in Midbrain NPCs""

""4. Function of Dlx-induced Expression of Wnt5a in GABAergic Interneuron Progenitors of the Olfactory Bulb (OB)""""Conclusion""; ""Acknowledgments""; ""References""; ""Chapter 5: Endothelial Progenitor Cells in Clinical Settings""; ""Abstract""; ""Introduction""; ""Contribution of EPC to Endothelial Cell Repair and Vascular Cell Senescence""; ""Angiogenic Cytokines and Clinical Outcome""; ""Vascular Endothelial Growth Factor (VEGF)""; ""Fibroblast Growth Factor (FGF)""; ""Hepatocyte Growth Factor (HGF)""

""HGF, But Not VEGF and FGF, Prevent Inflammation, Cell Senescence, and Tissue Fibrosis""

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on online resource; title from PDF title page (ebrary, viewed November 27, 2013).

ISBN:

1-62808-995-4