Protein-protein interactions / Pandjassarame Kangueane, editor.

Format:

Book

Contributor:

Kangueane, Pandjassarame.

Series:

Biochemistry Research Trends

Biochemistry research trends

Nova biomedical

Language:

English

Subjects (All):

Protein-protein interactions.

Protein binding--Physiology.

Protein binding.

Physical Description:

1 online resource (350 p.)

Place of Publication:

New York : Nova Science Publishers, c2011.

Language Note:

English

Summary:

Describes the fundamental physical, chemical, molecular and biological aspects of proteins binding to one another in cellular biology. This title explains the principles (physics and chemistry) of PPI and protein interfaces to develop models for PPI predictions.

Contents:

""PROTEIN-PROTEIN INTERACTIONS ""; ""PROTEIN-PROTEIN INTERACTIONS ""; ""CONTENTS ""; ""PREFACE ""; ""ACKNOWLEDGMENTS""; ""PROTEIN�PROTEIN COMPLEXES ""; ""ABSTRACT""; ""1.1. INTRODUCTION ""; ""1.2. CURRENT TRENDS AND PROGRESS ON PPI ""; ""1.3. STRUCTURAL DATASET SIZE IN PPI STUDIES ""; ""1.4. PERMANENT AND NON-OBLIGATE COMPLEXES ""; ""1.5 PPI DATASET""; ""1.6. PPI DATASET REFERRED IN THIS CHAPTER""; ""1.7. PROTEIN SIZES ""; ""1.7.1. Heterodimer Complexes""; ""1.7.2. Size Based Grouping of Complexes""; ""1.7.3. Modes of Interface Interaction""

""1.7.4. Interface and Interface Residues in 1D, 2D and 3D """"1.7.5. Homodimer Complexes""; ""1.8. FUNCTIONAL CLASSIFICATION OF HETERO-DIMER COMPLEXES ""; ""1.9. FUNCTIONAL CLASSIFICATION OF HOMO-DIMER COMPLEXES ""; ""1.10. Structural Features""; ""1.10.1. Physical-chemical Propertie ""; ""1.10.2. Interface size and Interface Residues ""; ""1.10.3. Size and Interface Area in Heterodimer Complexes ""; ""1.10.4. Size and Interface Area in Homodimer Complexes ""; ""1.10.5. Interface Residues in Hetero Complexes""; ""1.10.6. Interface Residues in Homo Complexes ""

""1.10.7. Interface Planarity """"1.10.8. Interface Hydrogen Bonds ""; ""1.10.9. Interface Chemical Property ""; ""1.10.10. Interface Residue Composition""; ""1.10.11. Interface Hydrophobicity and Hydrophilicity""; ""1.10.12. Interface Hydrophobic Effect""; ""1.10.13. Interface Electrostatic Interactions ""; ""1.10.14. Interface Residue Propensity ""; ""1.10.15. Interface Properties at the PROTORP Database ""; ""1.11. CLASSIFICATION OF HETERO COMPLEXES BASED ON INTERFACE RESIDUE PROPERTIES ""; ""1.12. CLASSIFICATION OF HOMO COMPLEXES BASED ON INTERFACE RESIDUE PROPERTIES ""

""1.13. CONCLUSION""""1.14. EXERCISES ""; ""REFERENCES ""; ""PREDICTION OF HIGHLY-CONNECTED HUBS IN PROTEIN INTERACTION NETWORKS BY QSAR AND BIOLOGICAL DATA DESCRIPTORS ""; ""ABSTRACT ""; ""2.1. INTRODUCTION ""; ""2.2. METHODOLOGY ""; ""2.2.1. Acquisition and Analysis of Protein-Protein Interaction Data ""; ""2.2.2. Calculation and Collection of Protein Descriptors ""; ""2.2.3. Gene Ontology (GO) Annotations ""; ""2.2.4. Sequence Similarity ""; ""2.2.5. Number of Pfam Protein Domains ""; ""2.2.6. Protein Threading Scores and SCOP Protein Domain Composition ""

""2.2.7. Physicochemical Properties """"2.2.8. Training and Testing Hub Classifiers by Boosting Trees ""; ""2.3. RESULTS AND DISCUSSION ""; ""2.3.1. Prediction Performance of the Hub Prediction Classifiers ""; ""2.3.2. Prediction Performance of a Traditional Hub Prediction Approach Based on Sequence Conversation ""; ""2.3.3. Characteristics of Hub and Non-hub Proteins""; ""2.3.4. Gene Ontology (GO) Annotations ""; ""2.3.5. Sequence Similarity ""; ""2.3.6 Number of Pfam Protein Domains ""; ""2.3.7. Protein Threading Scores and SCOP Protein Fold Composition ""

""2.3.8. Physicochemical Properties ""

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-61122-098-X