Hepatitis B virus : molecular mechanisms in disease and novel strategies for therapy / editors, Rajen Koshy, Wolfgang H. Caselmann.

Format:

Book

Contributor:

Koshy, Rajen.

Caselmann, Wolfgang H.

Language:

English

Subjects (All):

Hepatitis B virus.

Hepatitis B.

Physical Description:

1 online resource (342 p.)

Place of Publication:

London : Imperial College Press ; River Edge, NJ : World Scientific [distributor], 1998.

Language Note:

English

Summary:

The book covers both the molecular aspects of hepatitis B virus replication and gene expression in vivo and in model systems, and the clinical impact of genetic variants or immunological response in chronic infection. Major emphasis is laid on the molecular mechanisms underlying hepatitis B virus-associated liver carcinogenesis and their possible relevance to therapy and to the prevention of infection. Rational approaches to design novel vaccines or cytokine treatments, as well as strategies to develop vectors for liver-directed gene therapy, are discussed.

Contents:

PREFACE; CONTENTS; Chapter 1 REPLICATION OF THE HEPATITIS B VIRUS GENOME; Introduction; Virus Entry and Formation of Covalently Closed Circular (CCC) DNA; Assembly of Core Particles and Priming of Reverse Transcription; Viral DNA Synthesis; Assembly of Virions Versus Amplification of CCC DNA; Implications for Antiviral Therapy; Summary; Acknowledgements; References; Chapter 2 THE REGULATION OF HEPATITIS B VIRUS GENE EXPRESSION: AN OVERVIEW OF THE CIS- AND TRANS-ACTING COMPONENTS; Introduction; HBV Transcriptional Control Elements; Surface Antigen Promoters

Core/Pregenomic Promoter and Enhancer 2X Promoter and Enhancer 1; Effects of HBx on Viral and Cellular Gene Expression; Conclusions; Acknowledgements; References; Chapter 3 ANIMAL MODELS AND EXPERIMENTAL SYSTEMS IN HEPATITIS B VIRUS RESEARCH; Introduction; The Family of Hepadnaviridae; Animals Susceptible to Hepadnaviral Infection; Animal Models for HBV; Models With Related Mammalian and Avian Hepadnaviruses; Transgenic Animals in HBV Research; In Vitro Systems to Study Carcinogenesis by HBV; In Vitro Systems to Study the Infection Process of HBV; Resume; References

Chapter 4 NATURAL COURSE OF HBV INFECTIONIntroduction; Epidemiology and Transmission; Host Range, Target Cells and Pathogenesis of HBV Infection; Diagnosis of HBV Infection; Natural Course of HBV Infection; Acute Hepatitis B; Chronic Hepatitis; Rare Clinical Courses of HBV Infection; HBV Reactivation; Extra-hepatic Manifestations of HBV Infection; HBV Co-infections or Superinfections; HBV and HDV; HBV and HCV; HBV and GBV-C/HGV; HBV and HIV; Summary and Perspectives; References; Chapter 5 GENETIC VARIANTS OF HBV; Introduction; The Core ORF; HBV Infections Without an Anti-HBc Response

The Surface ORFThe x ORF; The Polymerase ORF; Conclusions; References; Chapter 6 THE IMMUNOLOGY OF CHRONIC HEPATITIS B; Introduction; Concepts and Models of the HBV-Specific Immune Response; Characterisation of the HBV-Specific Immune Response During the Natural Course of HBV Infection in Adults; The Humoral Immune Response; The Class II Restricted Immune Response; The Class I Restricted Immune Response; The Immune Response During Chronic Hepatitis B; Epidemiology of Chronic Hepatitis; Pathogenetic Role of the Immune Rresponse

The Immune Response Associated with Recovery from Acute and Chronic HBV InfectionOutlook: New Vaccination Strategies for Chronic HBV Infection; References; Chapter 7 HBV DNA INTEGRATION AND INSERTIONAL MUTAGENESIS; Integration of HBV DNA in Chronic Hepatitis and Hepatocellular Carcinoma Tissues; Gross Structures of Integrated HBV DNA and Cellular Flanking DNA; Limited Sequence Homology at the Virus-virus Junction; HBV DNA Rearrangement Prior to Integration; Trans-activation Function of Integrated HBV DNA; Integrated HBV DNA Preserves a Serine Protease Inhibitor Domain-like Structure

Insertional Activation of Cellular Genes

Notes:

Description based upon print version of record.

Includes bibliographical references and indexes.

ISBN:

9781848161078

1848161077