DNA adducts : formation, detection and mutagenesis / Emerson Alvarez and Roberto Cunha, editors.

Format:

Book

Contributor:

Álvarez, Emerson.

Cunha, Roberto.

Series:

DNA--properties and modifications, functions and interactions, recombination and applications series.

DNA : properties and modifications, functions and interactions, recombination and applications series

Language:

English

Subjects (All):

DNA adducts.

Genetic toxicology.

Physical Description:

1 online resource (248 p.)

Place of Publication:

New York : Nova Biomedical Books, c2010.

Language Note:

English

Summary:

Numerous physical and chemical stress factors, endogenous or exogenous, challenge living organisms. Metabolisation processes generate highly reactive intermediates which can covalently bind to DNA, resulting in bulky addition products called "adducts." DNA adduct formation appears to be a general response of plants to organic chemical exposure, whether in controlled conditions or in the field. In particular, common carcinogenic pollutants and pesticides promote the formation of DNA adducts in plants. The authors of this book examine the development of DNA adducts, as well as the ways in which they can be eliminated due to DNA repair pathways. In this book, the data from in vivo transgenic assays is also examined, which can help to clarify specific pre-mutagenic adducts, DNA repair functions and mutational events that may be involved in the mutagenicity of human carcinogens. Other chapters in this book identify and discuss novel anthracyclines capable of forming DNA adducts, the role of DNA adducts as early biomarkers in the screening and development of marine anticancer drugs, the genotoxicity, such as DNA adduct formation, of air pollutants and its assessment by in vivo mutagenesis and a discussion of oxidative DNA damage, which can play an important role in the carcinogenic processes of PAHs and aromatic amines, in addition to bulky-DNA adducts formation.

Contents:

Tidying up a molecular catastrophe : in vitro and in vivo repair of unique DNA-protein cross links / David J. Baker, Arthur D. Riggs, Timothy R. O'Connor

In vivo mutagenic effects of alkylating agents eliciting different DNA-adducts / Henriqueta Louro, Maria Joao Silva

DNA adduct formation and genotoxicity assessment in plants / Frederique Weber-Lotfi ... [et al.]

Diet, life-style habits and malondialdehyde-deoxyguanosine adducts in a group of subjects resident in the Rayong Province, Thailand / M. Peluso ... [et al.]

Drug-DNA adducts formed by formaldehyde activation of anthracyclines and related anti-cancer agents / Don R. Phillips ... [et al.]

Differential modulation of benzo(a)pyrene-derived DNA adducts in MCF-7 cells by marine compounds / Jamal M. Arif ... [et al.]

Potency of air pollutants at DNA adduct formation and assessment by in vivo mutagenesis / Yasunobu Aoki ... [et al.]

GSTM1 and XRCC3 polymorphisms : effects on the levels of aflatoxin B1-DNA adducts / Xi-Dai Long ... [et al.]

Oxidative DNA damage and DNA adducts induced by polycyclic aromatic hydrocarbons and aromatic amines / Shosuke Kawanishi and Shiho Ohnishi

Usefulness of bulky DNA adduct formation as a biological marker of exposure to airborne particulate matter (PM2.5) in in vitro cell lung models : a comparative study / Sylvain Billet ... [et al.].

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-61324-344-8