Principles of bacterial pathogenesis / edited by Eduardo A. Groisman.

Format:

Book

Contributor:

Groisman, Eduardo Abraham, 1956-

Language:

English

Subjects (All):

Pathogenic bacteria.

Virulence (Microbiology).

Physical Description:

1 online resource (863 p.)

Place of Publication:

San Diego, Calif. : Academic Press, c2001.

Language Note:

English

Summary:

Principles of Bacterial Pathogenesis presents a molecular perspective on a select group of bacterial pathogens by having the leaders of the field present their perspective in a clear and authoritative manner. Each chapter contains a comprehensive review devoted to a single pathogen. Several chapters include work from authors outside the pathogenesis field, providing general perspectives on the evolution, regulation, and secretion of virulence and determinants.Key Features* Explains the basic principles of bacterial pathogenesis* Covers diverse aspects integrating regulat

Contents:

Front Cover; Principles of Bacterial Pathogenesis; Copyright Page; Contents; Contributors; Preface; Chapter 1. Evolution of Bacterial Pathogens; I. Introduction; II. The Genetic Basis of Virulence; III. Identification of Sequences Involved in Bacterial Pathogenesis; IV. Recovery of Genes Contributing to Virulence; V. The Population Genetics of Pathogens; VI. Studying Bacterial Population Genetics; VII. The Organization of Genetic Diversity in Pathogenic Microorganisms; VIII. Population Genetics of Representative Bacterial Pathogens; IX. Conclusions; References

Chapter 2. Germ Warfare: The Mechanisms of Virulence Factor DeliveryI. Introduction; II. The General Secretory Pathway; III. Autotransporters: Type V; IV. Two-Step Secretion: Type II; V. ABC Transporters: Type I; VI. Conjugal Transfer Systems: Type IV; VII. Contact-Dependent Secretion: Type III; VIII. Concluding Remarks; References; Chapter 3. Regulation of Virulence Gene Expression in Bacterial Pathogens; I. Introduction; II. Transcription Initiation; III. Regulatory Protein Families; IV. Covalent Modification of Transcription Factors; V. Regulatory Networks

VI. The Oxidative Stress ResponseVII. The Modular Nature of Bacterial Regulatory Proteins; VIII. The Overlap between Genome Structure and Gene Regulation; IX. Other Classes of Protein Regulators; X. DNA Structure and Gene Regulation; XI. Stereotypical and Stochastic Events in the Control of Gene Expression; XII. The Switch Controlling Type 1 Fimbrial Expression in E. coli; XIII. Pap Pilus Gene Transcription; XIV. Contact-Dependent Gene Regulation; XV. The Virulence Gene Regulatory Cascade of S. flexneri; XVI. A Thermometer Protein from the Salmonella Virulence Plasmid

XVII. Cell-Density-Dependent RegulationXVIII. Adaptive Mutation; XIX. Rare tRNAs and Translation Modulation; XX. Protein Splicing; XXI. Antisense RNA; XXII. Perspective; References; Chapter 4. Strategies to Identify Bacterial Pathogenicity Factors; I. Introduction; II. Biochemical Strategies; III. Genetic Screens; IV. Genetic Selections; V. Genomic Approaches; VI. Concluding Remarks; References; Chapter 5. Mechanisms of Bacterial Pathogenesis in Plants: Familiar Foes in a Foreign Kingdom; I. Introduction; II. An Overview of Bacterial Plant Pathogens and Plant Diseases

III. Tumorigenic Agrobacterium tumefaciens: Using the Type IV Secretion System to Transform the Host into a Factory for Bacterial NutrientsIV. Necrogenic, Stealth Pathogens: Parasites Strongly Dependent on the Hrp (Type III) Protein Secretion System; V. Necrogenic, Brute-Force Pathogens: Soft-Rotters Dependent on Type II Secretion of Pectic Enzymes; VI. Other Virulence Factors of Gram-Negative Plant Pathogens Compared with Those of Animal Pathogens; VII. Host Innate Immune Systems: Common Components in Pathogen Recognition and Defense Signaling

VIII. The R Gene Surveillance System: An Innate Immune System with Elaborate Recognition Specificity

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-01878-3

9786611018788

0-08-053958-0

1-4356-0119-X

OCLC:

630529262