Autophagy Networks in Inflammation / edited by Maria Chiara Maiuri, Daniela De Stefano.

Format:

Book

Contributor:

Maiuri, Maria Chiara., Editor.

De Stefano, Daniela., Editor.

Series:

Progress in Inflammation Research, 0379-0363

Language:

English

Subjects (All):

Immunology.

Cytology.

Infectious diseases.

Cell Biology.

Infectious Diseases.

Local Subjects:

Immunology.

Cell Biology.

Infectious Diseases.

Physical Description:

1 online resource (XV, 403 p. 20 illus., 16 illus. in color.)

Edition:

1st ed. 2016.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2016.

Summary:

Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.

Contents:

Autophagy in direct pathogen elimination (Xenophagy)

Autophagy and pattern recognition receptors

Autophagy and inflammasomes

Autophagy and Antigen presentation

Autophagy and regulation of T and B cell function

Autophagy in chronic inflammation

The complex crosstalk between autophagy and ROS

Lipophagy

Autophagy, phagocytosis and entosis: who eats whom?- Which is the cell fate of inflammatory cells ? Autophagic cell death, pyroptosis, netosis, apoptosis, necrosis

Host defence (virus/bacteria)

Neurological diseases

Pulmonary diseases (emphysema, COPD, etc.)

Inflammatory bowel disease

Target autophagy as a novel therapeutic strategy in autoimmune diseases

Liver and pancreatic diseases

Obesity

Aging

Overview on clinical trials.

Notes:

Includes bibliographical references at the end of each chapters and index.

ISBN:

3-319-30079-2