Cellular implications of redox signaling / editors, Carlos Gitler, Avihai Danon.

Format:

Book

Contributor:

Danon, A.

Gitler, Carlos.

Language:

English

Subjects (All):

Oxidation-reduction reaction.

Photochemistry.

Physical Description:

1 online resource (441 p.)

Place of Publication:

London : Imperial College Press, c2003.

Language Note:

English

Summary:

Redox regulation, like phosphorylation, is a covalent regulatory system that controls many of the normal cellular functions of all living cells and organisms. In addition, it controls how cells respond to stress involving oxidants and free radicals, which underlie many degenerative diseases. This area is undergoing a transition from general knowledge to specific description of the components and mechanisms involved. This invaluable book provides a timely basic description of a field whose relevance to cell biology and degenerative diseases is of the utmost importance. It describes the state

Contents:

Contents; Preface; Chapter 1 The Role of Thioredoxin and Glutaredoxin Systems in Disulfide Reduction and Thiol Redox Control; 1. Summary; 2. Introduction and Historical Perspective; 3. The Thioredoxin System; 3.1 Thioredoxin Reductase and Selenium; 3.2 Structure of Mammalian Thioredoxin Reductase; 4. The Glutaredoxin System; 5. Redox Regulation of Cellular Function; 6. Future Perspectives; Acknowledgments; References; Chapter 2 Selenocysteine Insertion and Reactivity: Mammalian Thioredoxin Reductases in Relation to Cellular Redox Signaling; 1. Summary; 2. The Mammalian Thioredoxin System

3. Selenocysteine in Thioredoxin Reductase3.1 Co-Translational Insertion of Selenocysteine; 3.2 Selenocysteine in TrxR as a Drug Target; 4. Regulation of Cytosolic Thioredoxin Reductase in Relation to Cellular Redox Signaling; 5. Effects of Dinitrohalobenzenes by Interactions with Thioredoxin Reductase; Acknowledgements; References; Chapter 3 Iron-Sulfur Proteins: Properties and Functions; 1. Summary; 2. Historical Comments; 3. Properties; 3.1 Structure; 3.2 Electronic Structure; 3.3 Stability; 3.4 Complex Fe-S Proteins; 3.5 Cluster Ligands; 3.6 Heterometal Clusters

3.7 Self-activation of 3Fe-enzymes3.8 Degradation and Biosynthesis of Fe-S Clusters; 4. Functions of Fe-S Proteins; 4.1 Electron Transfer; 4.2 Oxidation-Reduction Potentials; 4.3 Non-Redox Functions of Fe-S Proteins; 5. Conclusion and Outlook; References; Chapter 4 The Ferredoxin Ferredoxin/Thioredoxin Thioredoxin System. A light-Dependent Redox Regulatory System in Oxygenic Photosynthetic Cells; 1. Summary; 2. The Components of the Ferredoxin/Thioredoxin System; 2.1 Ferredoxin; 2.2 Ferredoxin:Thioredoxin Reductase; 2.3 Thioredoxins

3. The Redox Signal Transfer through the Ferredoxin/Thioredoxin System4. Target Enzymes; 4.1 Fructose 1,6-bisphosphatase; 4.2 NADP-Dependent Malate Dehydrogenase; 5. Concluding Remarks; Acknowledgment; References; Chapter 5 Thioredoxin and Redox Regulation: Beginnings in Photosynthesis Lead to a Role in Germination and Improvement of Cereals; 1. Summary; 2. Ferredoxin-Thioredoxin System; 2.1 NADP/Thioredoxin System; 3. Applications of Thioredoxin; 3.1 Alleviation of Allergies; 3.2 Improved Dough Quality; 4. Thioredoxin-Enriched Grain; 4.1 Cereal Transformations

4.2 Properties of Transgenic Cereals5. A New Development; References; Chapter 6 The Role of Thioredoxin in Regulatory Cellular Functions; 1. Summary; 2. Cytoprotective Effects of Thioredoxin; 3. Thioredoxin and its Related Molecules; 4. Thioredoxin Knock Out and Transgenic Mice; 5. Characteristics of Trx-Tg Mice; 5.1 Resistance Against Focal Cerebral Ischemic Injury; 5.2 Resistance Against Excitotoxic Hippocampal Injury; 5.3 Resistance Against Oxidative Stress and Elongated Survival; 5.4 Pancreatic Beta Cell Specific Overexpression of Thioredoxin; 6. Extracellular Function of Thioredoxin

7. A Truncated Form of Thioredoxin

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786611865764

9781281865762

1281865761

9781848160033

1848160038

OCLC:

748530816