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Mims' Pathogenesis of Infectious Disease / Cedric A. Mims, Anthony Nash and John Stephen.
- Format:
- Book
- Author/Creator:
- Fitzgerald, Ross.
- Language:
- English
- Subjects (All):
- Communicable diseases.
- Communicable Diseases--microbiology.
- Communicable Diseases--immunology.
- Bacterial Infections and Mycoses.
- Medical Subjects:
- Communicable Diseases--microbiology.
- Communicable Diseases--immunology.
- Bacterial Infections and Mycoses.
- Physical Description:
- 1 online resource (489 pages)
- Edition:
- 5th ed.
- Place of Publication:
- Burlington : Elsevier Science, 2000.
- Language Note:
- English
- Summary:
- Mims' Pathogenesis of Infectious Disease is the landmark book in the field of infectious disease. The new, revised edition of this work provides a comprehensive, up-to-date description of the mechanisms of microbial infection and the pathogenesis of infectious disease. Presented in a clear, accessible style, it deals in an integrated manner with the spectrum of microorganisms, describing the factors common to all infectious diseases. Molecular biology, pathology, and immunology are brought together to explain the mechanisms for spread, immune response, and recovery.
- Contents:
- Front Cover; Mims' Pathogenesis of Infectious Disease Fifth Edition; Copyright Page; Contents; Preface to the Fifth Edition; Preface to the Fourth Edition; Preface to the Third Edition; Preface to the Second Edition; Preface to the First Edition; Chapter 1. General Principles; References; Chapter 2. Attachment to and Entry of Microorganisms into the Body; Introduction; Adhesion/entry: some general considerations; The skin; Respiratory tract; Gastro-intestinal tract; Oropharynx; Urinogenital tract; Conjunctiva; The normal microbial flora; Exit of microorganisms from the body; References
- Chapter 3. Events Occurring Immediately After the Entry of the Microorganism; Growth in epithelial cells; Intracellular microorganisms and spread through the body; Subepithelial invasion; Nutritional requirements of invading microbes; References; Chapter 4. The Encounter with the Phagocytic Cell and the Microbe's Answers; Cell biology of phagocytosis; Phagocytosis in polymorphonuclear leucocytes; Phagocytosis in macrophages; Microbial strategy in relation to phagocytes; Growth in the phagocytic cell; Killing the phagocyte; Entry into the host cell other than by phagocytosis
- Consequences of defects in the phagocytic cell; Summary; References; Chapter 5. The Spread of Microbes through the Body; Direct spread; Microbial factors promoting spread; Spread via lymphatics; Spread via the blood; Spread via other pathways; References; Chapter 6. The Immune Response to Infection; Antibody response; T-cell-mediated immune response; Natural killer cells; Macrophages, polymorphs and mast cells; Complement and related defence molecules; Conclusions concerning the immune response to microorganisms; References; Chapter 7. Microbial Strategies in Relation to the Immune Response
- Infection completed before the adaptive immune response intervenes; Induction of immunological tolerance; Immunosuppression; Absence of a suitable target for the immune response; Microbial presence in bodily sites inaccessible to the immune response; Induction of inappropriate antibody and T-cell responses; Antibodies mopped up by soluble microbial antigens; Local interference with immune forces; Reduced interferon induction or responsiveness; Antigenic variation; Microorganisms that avoid induction of an immune response; References; Chapter 8. Mechanisms of Cell and Tissue Damage
- Infection with no cell or tissue damage; Direct damage by microorganisms; Microbial toxins; Indirect damage via inflammation; Indirect damage via the immune response (immunopathology); Other indirect mechanisms of damage; Diarrhoea; References; Chapter 9. Recovery from Infection; Immunological factors in recovery; Inflammation; Complement; Interferons; Multimechanistic recovery: an example; Temperature; Tissue repair; Resistance to re-infection; References; Chapter 10. Failure to Eliminate Microbe; Latency; Persistent infection with shedding ; Epidemiological significance of persistent infection with shedding
- Notes:
- Description based upon print version of record.
- Description based on publisher supplied metadata and other sources.
- ISBN:
- 1-281-11928-8
- 9786611119287
- 0-12-498265-4
- 0-08-053850-9
- OCLC:
- 437186450
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