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Immunoglobulin genes / edited by T. Honjo, F.W. Alt.
- Format:
- Book
- Language:
- English
- Subjects (All):
- Immunoglobulin genes.
- Ir genes.
- Physical Description:
- 1 online resource (463 p.)
- Edition:
- 2nd ed.
- Place of Publication:
- London ; San Diego : Academic Press, c1995.
- Language Note:
- English
- Summary:
- The immunoglobulin gene complex is responsible for generating an extraordinarily wide range of antibodies, each possessing a unique antigen specificity. The Second Edition of Immunoglobulin Genes brings the reader up to date with the rapid progress in our understanding of this system. Firmly established as the definitive book on the topic, it provides a fully comprehensive account of the organization, function, rearrangement and expression of these and related genes. Since the publication of the first edition, the work has been extensively revised and updated to cover new research data
- Contents:
- Front Cover; Immunoglobulin Genes; Copyright Page; Contents; Contributors; Foreword; Preface to first edition; Preface to second edition; PART I: B CELLS; Chapter 1. B-cell differentiation in humans; Chapter 2. The role of B cell and pre-B-cell receptors in development and growth control of the B-lymphocyte cell lineage; Chapter 3. The maturation of the antibody response; Chapter 4. Development of B-cell subsets; Chapter 5. Regulation of B-cell differentiation by stromal cells; Chapter 6. Antigen receptors on B lymphocytes; PART II: ORGANIZATION AND REARRANGEMENT OF IMMUNOGLOBULIN GENES
- Chapter 7. Immunoglobulin heavy chain loci of mouse and humanChapter 8. The human immunoglobulin k genes; Chapter 9. Immunoglobulin ? genes; Chapter 10. The variable region gene assembly mechanism; Chapter 11. Regulation of class switch recombination of the immunoglobulin heavy chain genes; Chapter 12. Generation of diversity by post-rearrangement diversification mechanisms: the chicken and the sheep antibody repertoires; Chapter 13. Immunoglobulin heavy chain genes of rabbit; Chapter 14. The structure and organization of immunoglobulin genes in lower vertebrates
- PART III: IMMUNOGLOBULIN GENE EXPRESSIONChapter 15. Ig gene expression and regulation in Ig transgenic mice; Chapter 16. B-lymphocyte tolerance in the mouse; Chapter 17. Immunoglobulin variable region gene segments in human autoantibodies; Chapter 18. Regulation of immunoglobulin gene transcription; Index
- Notes:
- Description based upon print version of record.
- Includes bibliographical references and index.
- ISBN:
- 1-281-03811-3
- 9786611038113
- 0-08-053451-1
- OCLC:
- 476100525
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