Frontiers in Clinical Drug Research : Diabetes and Obesity / edited by Atta-ur-Rahman.

Format:

Book

Author/Creator:

Rahman, Atta-ur, Author.

Contributor:

Rahman, Atta-ur-, 1942- editor.

Series:

Frontiers in Clinical Drug Research - Diabetes and Obesity

Frontiers in Clinical Drug Research - Diabetes and Obesity Series

Language:

English

Subjects (All):

Obesity.

Diabetes.

Diabetes--Treatment.

Physical Description:

1 online resource (188 pages)

Edition:

First edition.

Place of Publication:

Sharjah, UAE : Bentham Science Publishers, [2021]

Summary:

Frontiers in Clinical Drug Research - Diabetes and Obesity is an book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases - diabetes and obesity. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research - Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research. The first volume of this series features 6 chapters that cover a variety of topics including: -Angiotensin blockers-Agents targeting advanced glycation end products-Drugs and the peroxisome proliferator activated receptors-Topical Drugs for diabetic complications-Research on Liraglutide-Research on MicroRNAs as agents for diabetes treatment.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Preface

List of Contributors

The Failing Heart in Diabetes with Special Emphasis on Prevention

Sayak Roy1,* and Maneesha S. Khalse2

INTRODUCTION

EPIDEMIOLOGY AND GLOBAL BURDEN OF HF IN DIABETES

SPECIAL FOCUS ON BURDEN IN ASIANS

CLASSIFICATION OF CHRONIC HF - HFREF AND HFPEF

PROGNOSIS OF HF

PATHOGENESIS OF HF IN DIABETES

Renin Aldosterone Angiotensin System (RAAS)

Dyslipidaemia and Altered Cardiac Metabolism

Mitochondrial Dysfunction

Glucolipotoxicity

Myocardial Inflammation

Insulin Resistance

Advanced Glycated End Products

Sympathetic Overactivity

Diabetic Cardiomyopathy

Cardiac Autonomic Neuropathy (CAN)

CVOT IN LIGHT OF HF WITH ONGOING TRIALS ON DIABETIC HF POPULATIONS

DIAGNOSTIC TOOLS AND APPLICATIONS WITH THEIR LIMITATIONS

ANTI-DIABETIC DRUGS AND HF

CONCLUSION

CONSENT FOR PUBLICATION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

REFERENCES

Flavonoids as Prominent Anti-diabetic Agents

Aluru Rammohan1,* and Baki Vijaya Bhaskar2

INTRODUCTION TO DIABETES MELLITUS (DM)

DM-I/Type-1 DM

DM-II/Type-2 DM

The Third is Gestational Diabetes Mellitus (GDM)

CURRENT THERAPIES AND THEIR POTENTIAL THERAPEUTIC DIABETIC TARGETS

IMPORTANCE OF FLAVONOIDS

Classification and Biosynthesis of Flavonoids

FLAVONOIDS AS ANTIDIABETIC AGENTS

Antidiabetic Action and Molecular Mechanism of Flavonoids

Volumetric Evaluation of Active Site and Key Residues of Targets

Optimum Flavonoids for in silico Studies

Molecular Interaction of Flavonoids with Diabetic Targets

Toxic Profiles and Drug-likeness Assessments of Flavonoids

Flavonoids as Therapeutic Choices for Diabetic Mellitus and Associated Chronic Diseases

STRUCTURAL STUDIES OF FLAVONOIDS AS ANTI-DIABETIC AGENTS.

Clinical Trials of Flavonoids with Antidiabetic Strategies

CONCLUDING REMARKS

Chemosensor in Glucose Monitoring, Advances and Challenges

Hayat Ullah*, 1, Maliha Sarfraz*, 2, Misbah Ullah Khan3 and Munzer Ullah4

EMERGING GLUCOSE SENSORS

TYPICAL CHEMOSENSORS COMPOSITION

WEARABLE CHEMOSENSORS

PERMITTING MAIN TECHNOLOGIES OF WEARABLE CHEMOSENSORS

FLUORESCENT NANO-BIOSENSORS

FUTURE PROSPECTS

Synergistic Drugs and Polyherbal Formulations for Obesity: Current Status and Future Prospectives

Kavya. P1 and Gayathri. M1,*

ANTI-OBESITY ACTIVITY OF SYNERGISTIC DRUGS AND POLYHERBAL FORMULATIONS

In Vitro Anti-Obesity Activity

In Vivo Anti-Obesity Activity

Clinical Anti-Obesity Activity

CONCLUSION AND FUTURE DIRECTION

ACKNOWLEDGEMENT

Urge for Herbal Anti-Diabetic Medicines Towards Clinical and Therapeutic Implications

I.V. Asharani1,*, M. Gowtham2 and D. Thirumalai3

Herbal Anti-diabetic Medicines

NEED FOR HERBAL ANTI-DIABETIC DRUGS

Contamination

Adulteration

Misidentification

Convoluted Range of Phytochemicals

Irregular and Erratic Range of Phytochemicals

Irrational Collection Pattern of Anti-diabetic Plants

METHODS TO OVERCOME EXTERNAL ISSUES FACED BY HERBAL ANTI-DIABETIC DRUGS

HERB-DRUG INTERACTION

Initiation and Inhibition of Metabolic Enzymes

Initiation and Inhibition of Transport Efflux Proteins

Changes in Gastrointestinal Functions

Changes in the Renal Elimination

COMMONLY USED ANTI-DIABETIC PLANTS AND RELATED STUDIES

Abelmoschus Esculentus

Acanthopanax Senticosus.

Anemarrhena Asphodeloides

Bauhinia Megalandra

Beta Vulgaris

Capparis Decidua

Cassia Fistula

Cimicifuga Dahurica

Cleome Droserifolia

Cryptolepis Sanguinolenta

Eclipta Alba

Enicostemma Littorale

Ficus Bengalensis

Globularia Alypum

Hintonia Latiflora

Inula Racemosa

Larrea Tridentata

Morus Nigra

Myrcia Multiflora

Nelumbo Nucifera

Ophiopogon Japonicas

Curcuma Longa as Dietary Supplement and Diabetes Mellitus: Evidence from Experimental Studies

Maliha Sarfraz1,*, Hayat Ullah2,*, Ghulam Nabi3, Muhammad Asif Raza4, Rashid Iqbal5 and Shaheed Ullah2

GENERAL PROPERTIES OF CURCUMA LONGA

CHEMICAL CONSTITUENTS OF CURCUMA LONGA HAVING ANTIDIABETIC POTENTIAL

EFFECT OF CURCUMA LONGA ON GLUCOSE IN EXPERIMENTAL DIABETIC RATS

ANTIDIABETIC EFFECT OF CURCUMA LONGA IN DIABETIC ANIMALS

ANTIOXIDATIVE EFFECT OF CURCUMA LONGA

NEUROPROTECTIVE EFFECT OF CURCUMA LONGA

NEPHROPROTECTIVE EFFECT OF CURCUMA LONGA

ANTIDIABETIC EFFECTS OF CURCUMA LONGA IN HUMAN DIABETES MELLITUS

RELATIVE ASSESSMENT OF ANTIDIABETIC EFFECTS OF CURCUMA LONGA

RELATIVE ASSESSMENT OF ANTIDIABETIC IMPACTS OF CURCUMA LONGA AND HERBAL AGENTS

RELATIVE ASSESSMENT OF ANTIDIABETIC EFFECTS OF CURCUMA LONGA AND CONVENTIONAL ANTIDIABETIC AGENTS

PROBABLE MECHANISM OF ACTION OF CURCUMA LONGA FOR ANTIDIABETIC ACTIVITY

CURCUMA LONGA INHIBITS THE METABOLISM OF CARBOHYDRATE

CURCUMA LONGA INCREASES INSULIN PRODUCTION AND SENSITIVITY

CURCUMA LONGA EFFECTS ON LIPID PROFILES

CURCUMA LONGA INHIBITS INFLAMMATORY MEDIATORS

CURCUMA LONGA INHIBITS OXIDATIVE STRESS AND LIPID PEROXIDATION

REFERENCES.

Subject Index

Back Cover.

Notes:

Includes bibliographical references.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

ISBN:

9789811479199

9811479194

OCLC:

1290020144