Frontiers in Anti-Infective Agents.

Format:

Book

Author/Creator:

Singh, Parvesh.

Contributor:

Kumar, Vipan.

Karpoormath, Rajshekhar.

Series:

Frontiers in Anti-Infective Agents

Language:

English

Subjects (All):

Anti-infective agents.

Communicable diseases in pregnancy.

Physical Description:

1 online resource (194 pages)

Edition:

1st ed.

Place of Publication:

Singapore : Bentham Science Publishers, 2021.

Summary:

Anti-infective agents are a distinct class of pharmacologically important molecules that have served mankind in different capacities to combat life-threatening pathological conditions. They include antibacterial, antifungal, antiviral, antituberculosis, antimalarial and urinary anti-infective agents. However, evolutionary changes, adaptations and development of new strains of pathogenic microorganisms that have reduced the therapeutic efficacy of existing drugs, thus, limiting their clinical utility over the years. Frontiers in Anti-Infective Agents Volume 6 is a collection of notable research efforts, successful anti-infective drug development programmes and a comprehensive overview of successful and unsuccessful clinical trials conducted in this domain. This volume continues from the last one with interesting reviews on: 1) "Reverse Vaccinology" for vaccination design using computational data to identify vaccine targets, 2) leptospirosis, 3) phage therapy for bacterial infections, 4) quorum sensing inhibitors from natural products, and 5) nitrogen and oxygen based heterocyclic compounds that can act as anti-infective agents. The volume, therefore, covers a range of frontier topics on anti-infective research and development.This compilation is a timely reference for postgraduate scholars and researchers seeking updates in specific areas of anti-infective drug development. Allied healthcare professionals (clinical and public healthcare professionals) can also benefit from the information presented within.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Preface

List of Contributors

Reverse Vaccinology Approaches for Rapid Vaccine Design Against Emerging Infectious Diseases

Arindam Mitra1,*

INTRODUCTION

Reverse Vaccinology

Vaccines Developed by Using Reverse Vaccinology

Reverse Vaccinology for Intracellular Pathogens

Reverse Vaccinology Strategies to Design A Vaccine Against SARS-CoV-2

Bioinformatics Based Vaccine Predictive Tools

Challenges of Reverse Vaccinology

A Paradigm Shift in Vaccinology - Reverse Vaccinology 2.0

CONCLUSION

CONSENT FOR PUBLICATION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

REFERENCES

Leptospirosis - A Complete Review

N. Ramalakshmi1,*, S. Arunkumar2 and A. Puratchikody3

HISTORY OF LEPTOSPIROSIS

EPIDEMIOLOGY

MORPHOLOGY

CLINICAL FEATURES OF LEPTOSPIROSIS

CURRENT TREATMENT

DRUG TARGETS

CURRENTLY AVAILABLE DIAGNOSTIC TESTS

IgM-Enzyme Linked Immunosorbent Assay

IgM-dipstick Assay

The Indirect Hemagglutination Assay (IHA)

Molecular Diagnosis

Molecular Typing

NATURAL PRODUCTS FOR THE TREATMENT OF LEPTOSPIROSIS

SYNTHETIC ANALOGS FOR THE TREATMENT OF LEPTOSPIROSIS

BIOCHEMICAL PARAMETERS

HISTOPATHOLOGICAL CHANGES IN LEPTOSPIROSIS

IN SILICO STUDIES FOR LEPTOSPIRAL DRUGS

BIOMARKERS IN LEPTOSPIROSIS

PREVENTION AND CONTROL

ACKNOWLEDGEMENT

Phage Therapy as an Alternative Antibacterial Therapy

Nachimuthu Ramesh1,*, Prasanth Manohar2, Archana Loganathan1, Kandasamy Eniyan1 and Sebastian Leptihn2,3,4

History: From the Vault

Basics: Phage Life cycle and Phage Biology

Taxonomical Classification of Bacteriophages

Family: Ackermannviridae

Family: Autographiviridae

Family: Chaseviridae.

Family: Demerecviridae

Family: Drexlerviridae

Family: Herelleviridae

Family: Myoviridae

Family: Podoviridae

Family: Siphoviridae

Genus: Lilyvirus

Key Advantages and Disadvantages of Phage Therapy

PHAGE THERAPY: PHAGE RESISTANT BACTERIAL EVOLUTION

Phage Cocktails and Personalized Phage Therapy

Phage-Antibiotics Synergy

IMMUNOLOGICAL ASPECTS OF PHAGE THERAPY

Phage Transverse and Human Phageome

Phage-Immune System Crosstalk

Bacteriophage and Innate Immune Response

Bacteriophage and Humoral Immune Response

Synergistic Interaction of the Human Immune System and Phages

Pharmacodynamic and Pharmacokinetic Aspect of Phage Therapy

Phage Pharmacodynamics

Phage Pharmacokinetics

Adsorption

Distribution

Excretion and Metabolism

APPLICATION OF PHAGE THERAPY AGAINST BACTERIAL INFECTIONS

Phage Therapy for Wound Infections

Phage Therapy for Cystic Fibrosis

Phage Therapy for Urinary Tract Infections

Phage Therapy for Respiratory Infections

CHALLENGES AND THE FUTURE OF PHAGE THERAPY

Quorum Sensing Inhibitors from Natural Products: A New Anti-infective Approach

Debaprasad Parai1,*, Pia Dey2 and Samir Kumar Mukherjee2

ANTIMICROBIAL RESISTANCE AND ITS MECHANISMS

CURRENT UPDATE ON ANTIMICROBIAL RESISTANCE IN CHRONIC BACTERIAL INFECTIONS

QUORUM SENSING AND ITS IMPORTANCE IN BACTERIAL VIRULENCE

QUORUM SENSING INHIBITORS FROM NATURAL PRODUCTS

Phytochemicals

Marine Microorganisms

Marine Gram-positive Bacteria

Marine Gram-Negative Bacteria

Marine Fungi and Their Derivatives

MODES OF ACTION OF QSIS

Inactivation of QS Receptor

Inhibition of QS Signals Synthesis

Degradation of QS signals

Combined Application of Anti-QS Agents and Antibiotics.

FUTURE PERSPECTIVE

Nitrogen and Oxygen-based Heterocycles as Potential Anti-Infective Agents

Shaik Baji Baba2, Naresh Kumar Katari1,2,* and Rambabu Gundla1

1,2,4-TRIAZOLES

Antifungal Activity

Antibacterial Activity

Antiviral Agents

ISATIN: (1H-INDOLE- 2,3-DIONE)

Antibacterial Agents

Antitubercular Agents

COUMARIN

Antiviral Activity

SUMMARY AND PERSPECTIVE

Subject Index

Back Cover.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

9789814998420

9814998427

OCLC:

1281968158