Chemical biology : selected papers of H. Gobind Khorana (with introductions) / H. Gobind Khorana.

Format:

Book

Author/Creator:

Khorana, Har Gobind, 1922-

Series:

World Scientific Series in 20th Century Biology

World Scientific series in 20th century biology ; vol. 5

Language:

English

Subjects (All):

Biochemistry.

Molecular biology.

Physical Description:

1 online resource (633 p.)

Place of Publication:

Singapore ; River Edge, NJ : World Scientific, c2000.

Language Note:

English

Summary:

The first two chapters of this invaluable book trace the developments of the chemistry and macromolecular structures, respectively, of proteins and nuclei acids. Similarly, the introductions to the succeeding chapters review, step by step, the historical landmarks in the topics covered. These include discoveries of biological phosphate esters, nucleotides and nucleotide coenzymes (important in intermediary metabolism), the nature of the genetic material and biological synthesis of proteins, formulation of the problem of the genetic code, and perspectives on bioenergetics.The selected papers il

Contents:

Contents; Preface; Chapter 1 Development of the Chemistry and Macromolecular Structures of Proteins; Summary; Early History: Discovery of Amino Acids; Peptide (Amide) Theory of Protein Structure; Determination of the Amino Acid Composition of Proteins; Identification of the N-Terminal and C-Terminal Amino Acids in Peptides and Proteins; Determination of the Sequence of Amino Acids in Peptides and Proteins; Stepwise Degradation of Polypeptides from the α-Amino End; Selective Cleavage of Proteins to Form Relatively Large Fragments; Chemical Synthesis of Polypeptides

The 1955 Gordon Conference on Proteins: A High Point Signaling the Beginning of a New Era in Protein ChemistryThree-Dimensional Crystal Structures of Proteins; Three-Dimensional Structures of Proteins in Solution by NMR; The Second Revolution in Protein Sequencing: Sequences of Membrane Proteins Deduced from the Corresponding Gene Sequences; Site-Specific Mutagenesis in Protein Structure-Function Studies; Mass Spectrometry in Protein Sequencing and Protein-Protein Interactions; Bibliography; Selected Paper; STRUCTURAL INVESTIGATION OF PEPTIDES AND PROTEINS; 1. Introduction

2. Amino-acid Analysis3. Terminal Amino-acids in Peptides and Proteins; 4. Partial Hydrolysis; 5. Selective Chemical Degradation; 6. Enzymic Degradation; 7. Occurrence of D-Amino-acids in Naturally Occurring Peptides; Chapter 2 Development of the Chemistry and Macromolecular Structures of Nucleic Acids; Summary; Discovery of the Nucleic Acids and Early Work on Characterization of Their Chemical Constituents; Chemical Structures of Nucleic Acid Components; (a) Purines and pyrimidines; (b) The sugars, D-ribose and 2-deoxy-D-ribose; (c) Ribonucleosides and deoxyribonucleosides

(d) Structures of nucleotides and clarification of the internucleotidic linkage in nucleic acidsDNA Forms a Double-Stranded Helix (Watson-Crick Structure); Discoveries of Other Forms of DNA and Macromolecular Structure for RNA; Gordon Conference on Nucleic Acids 1958; Bibliography; Chapter 3 Carbodiimides as Synthetic Reagents; Summary; Organic Chemistry Since the 1940's; Rediscovery of Carbodiimides and Their Development as Synthetic Reagents; Bibliography; Laboratory Publications; Laboratory Colleagues; Selected Papers; THE CHEMISTRY OF CARBODIIMIDES; I. INTRODUCTION

II. PREPARATION OF CARBODIIMIDESA. FROM THIOUREAS; 1. Preparation of thioureas; 2. Conversion of thioureas to carbodiimides; B. MISCELLANEOUS METHODS; III. PROPERTIES OF CARBODIIMIDES; A. PHYSICAL PROPERTIES; 1. Stability and polymerization; 2. Infrared spectra; 3. Stereochemistry; B. CHEMICAL PROPERTIES; 1. Reaction with acids; 2. Base-catalyzed addition reactions; C. COMPARISON OF CARBODIIMIDES WITH SIMILAR SYSTEMS; IV. USES OF CARBODIIMIDES; V. REFERENCES

Carbodiimides. VIII. Observations on the Reactions of Carbodiimides with Acids and Some New Applications in the Synthesis of Phosphoric Acid Esters

Notes:

Description based upon print version of record.

Includes bibliographical references.

ISBN:

9789812813626

9812813624