New transcription factors and their role in diabetes and therapy.

Format:

Book

Series:

Advances in molecular and cellular endocrinology ; v. 5.

Advances in molecular and cellular endocrinology ; v. 5

Language:

English

Subjects (All):

Transcription factors.

Diabetes--Genetic factors.

Diabetes.

Diabetes--Pathophysiology.

Diabetes Mellitus, Type 2.

Transcription Factors.

Diabetes Mellitus, Type 2--genetics.

Diabetes Mellitus, Type 2--physiopathology.

Medical Subjects:

Diabetes Mellitus, Type 2.

Transcription Factors.

Diabetes Mellitus, Type 2--genetics.

Diabetes Mellitus, Type 2--physiopathology.

Physical Description:

1 online resource (331 p.)

Place of Publication:

Amsterdam ; Oxford : Elsevier, 2006.

Language Note:

English

Summary:

This book contains contributions from some of the most eminent experts in the fields of genetics, biochemistry, and pathophysiology of diabetes. Through specific examples, with broad applications, this book provides a comprehensive look at how transcription factors may underline the pathogenetic mechanisms of diabetes and obesity. Volume 5 provides an overview of the status of the field, while also providing valuable information of practical utility to those who do not necessarily work in this field. The integration of basic biology with physiologically and clinically relevant prot

Contents:

Cover; Contents; Preface; List of contributors; Chapter 1. Transcription factor genes in type 2 diabetes; 1. Introduction; 2. The PPARG gene; 3. Maturity onset diabetes of the young (MODY); 4. Transcription factor MODY genes; 5. Conclusion; Acknowledgements; References; Chapter 2. PPARγ, a key therapeutic target in the metabolic syndrome - unique insights derived from the study of human genetic variants; 1. Introduction; 2. PPARγ - a 'metabolic' nuclear receptor; 3. PPARγ - human genetic variants; 4. PPARγ - a rational therapeutic target in the human metabolic syndrome

5. Conclusions and future directionsReferences; Chapter 3. PPARδ: Emerging therapeutic potential of novel agonists in lipid and glucose homeostasis; 1. Introduction; 2. PPARδ: the rise of an abandoned orphan; 3. PPARδ in lipid and carbohydrate metabolism: a potential phoenix from the ashes; Acknowledgements; References; Chapter 4. Liver X receptors as potential drug targets for diabetes and its disorders; 1. Introduction to LXR; 2. LXR signaling in carbohydrate metabolism; 3. LXR signaling in lipid and cholesterol metabolism; 4. The LXRs control energy homeostasis

5. The LXRs are anti-atherosclerotic and anti-inflammatory factors6. Cross-talk between the LXRs and other NRs regulates overall body homeostasis; 7. Perspectives; References; Chapter 5. SREBP-1c regulation of nutrient homeostasis and lipid accumulation; 1. Introduction; 2. Structure, genes and tissue distribution of SREBP isoforms; 3. Regulation of SREBP-1c transcriptional activity; 4. SREBP target genes; 5. Mechanisms involved in glucose action: involvement of the ''Carbohydrate Response Element Binding Protein'' transcription factor; 6. SREBPs and physiopathology; 7. Conclusion

AcknowledgmentsReferences; Chapter 6. The adipocyte and adipose tissue as endocrine organs: Impact on the insulin resistance phenotype; 1. Embryonic development of adipose tissue and the role of angiogenesis; 2. Expansion of adiose tissue mass: hypertrophy versus hyperplasia and impact on adipocyte function; 3. Adipose tissue distribution and its relation to metabolism-depot specificity; 4. Impact of PPAR agonists on adipokines in disease states; References; Chapter 7. FOXC2 in the adipocyte; 1. Introduction; 2. The gene and its expression profile; 3. Function in metabolism

4. Regulation of FOXC25. WAT versus BAT; 6. Protection against diet-induced insulin resistance; 7. Human data; 8. The autonomic nervous system; 9. Future; Acknowledgment; References; Chapter 8. Regulation of adipocyte differentiation and metabolism by Wnt signaling and C/EBP transcription factors; 1. Introduction; 2. Roles for Wnt signaling in adipogenesis and glucose homeostasis; 3. Role of C/EBPS in hepatocyte differentiation and liver metabolism; 4. Roles for C/EBPs in adipocyte differentiation and metabolism; Acknowledgments; References

Chapter 9. GATA proteins as molecular gatekeepers of adipogenesis

Notes:

Description based upon print version of record.

ISBN:

9786610635979

9781280635977

1280635975

9780080463551

008046355X

OCLC:

476018324