Critical reviews of oxidative stress and aging [electronic resource] . Volume I : advances in basic science, diagnostics and intervention / editors, Richard G. Cutler, Henry Rodriguez.

Format:

Book

Contributor:

Cutler, Richard G.

Rodriguez, Henry, 1963-

Language:

English

Subjects (All):

Aging--Molecular aspects.

Oxidation, Physiological.

Stress (Physiology).

Physical Description:

1 online resource (1622 p.)

Other Title:

Oxidative stress and aging

Place of Publication:

New Jesery : World Scientific, c2003.

Language Note:

English

Summary:

This innovative and comprehensive reference book provides the most up-to-date information pertaining to the translational research field of oxidative stress and aging. <i>The book focuses on understanding the molecular basis of oxidative stress and its associated age-related diseases with the goal being the development of new and novel methods in treating the human aging processes</i>. The book charts the course of this new and rapidly emerging field of <i>Oxidative Stress Diagnostics and Therapeutics</i> that will have a significant impact on the future economics, science and practice of med

Contents:

Volume 1 ; Contents; Acknowledgments; Preface; List of Contributors; SECTION 1 Historical Perspectives; Chapter 1 Metabolic Rate, Free Radicals and Aging; 1. Introduction; 2. Metabolic Rate and Lifespan (Rubner's Metabolic Potential); 3. The Rate of Living Theory; 4. The Free Radical Theory of Aging; 5. Free Radicals, Damage and Aging; 6. The Oxidant/Antioxidant Equilibrium; 7. Active Oxygen and Signal Transduction; 8. Summary; References; SECTION 2 Free Radical Chemistry and Biology; Chapter 2 Spin-Trapping Methods for Detecting Superoxide and Hydroxyl Free Radicals In Vitro and In Vivo

1. Summary2. Choice of Spin Trap; 3. Superoxide; 4. Hydroxyl Radical; 5. In Vivo Hydroxyl Radical Detection; 6. In Vivo and In Vitro Superoxide; 7. DTP A, EDTA, and Desferal; References; Chapter 3 Peroxyl and Alkoxyl Radical Mediated DNA Damage; 1. Introduction: Alkyl Radicals to Oxyradicals - The Oxygen Effect; 2. Lifetimes and Diffusion of Oxyradicals; 3. Relative Reactivities of Peroxyl and Alkoxyl Radicals; 4. Methods for the Generation of Peroxyl and Alkoxyl Radicals; 5. Peroxyl and Alkoxyl Radical Mediated DNA Strand Breaks; 6. DNA Base Modifications by Peroxyl and Alkoxyl Radicals

7. ConclusionsAcknowledgment; References; Chapter 4 Nitric Oxide, Peroxynitrite and Ageing; 1. Introduction; 2. Why Do Tissues Produce Oxidants?; 3. Nitric Oxide; 4. Why is Nitric Oxide Used as an Intercellular Messenger?; 5. The Limited Reactivity of Nitric Oxide In Vivo; 6. Nitrogen Dioxide; 7. Peroxynitrite; 8. Nitrative versus Nitrosative Stress; 9. Tyrosine Nitration; 10. Alternative Mechanisms of Nitration; 11. Proteins Susceptible to Nitration; 12. Nitration of Prostacyclin Synthase; 13. Nitration of Structural Proteins; 14. Resistance to Viral Infections

15. Ageing, Nitrative Stress and the Central Nervous System16. Conclusions; Abbreviations Used; References; SECTION 3 Redox Regulation and Cell Signaling; Chapter 5 Thioredoxin-Dependent Redox Regulation - Implication in Aging and Neurological Diseases; 1. Summary; 2. Introduction; 3. TRX and Its related Molecules; 4. TRX Binding Proteins; 5. Redox Regulation of Transcription Factors by TRX; 6. Redox Regulation of Apoptosis by TRX; 7. Cytoprotective Effects of TRX; 8. Aging and TRX Overexpressing Transgenic Mice; 9. Oxidative Stress and Central Nervous System; 10. Conclusion; References

Chapter 6 Redox Regulation of Genes and Cell Function1. Introduction; 2. The Thioredoxin System; 3. The Glutaredoxin System; 4. Redox Regulation by Thioredoxin and Glutaredoxin; 5. Effects of Oxidants and Antioxidants; 6. Future Perspectives; Acknowledgments; References; Chapter 7 Oxidative Stress and Signal Transduction Pathway of Redox Sensor Proteins: Clinical Applications and Novel Therapeutics ; 1. Introduction; 2. Source of ROS as Signaling Molecules; 3. Mechanism of Oxidant Signaling; 4. Transcription Factor AP-1 and Its Redox Regulation

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9789812775733

9812775730

OCLC:

879025058