Methuselah flies : a case study in the evolution of aging / [edited by] Michael R. Rose, Hardip B. Passananti, Margarida Matos.

Format:

Book

Contributor:

Rose, Michael R. (Michael Robertson), 1955-

Passananti, Hardip Brar.

Matos, Margarida.

Language:

English

Subjects (All):

Drosophila--Aging.

Drosophila.

Insects--Aging.

Insects.

Physical Description:

1 online resource (495 p.)

Place of Publication:

Singapore : World Scientific, c2004.

Language Note:

English

Summary:

Methuselah Flies presents a trailblazing project on the biology of aging. It describes research on the first organisms to have their lifespan increased, and their aging slowed, by hereditary manipulation. These organisms are fruit flies from the species Drosophila melanogaster, the great workhorse of genetics. Michael Rose and his colleagues have been able to double the lifespan of these insects, and improved their health in numerous respects as well. The study of these flies with postponed aging is one of the best means we have of understanding, and ultimately achieving, the postponement of aging in humans. As such, the carefully presented detail of this book will be of value to research devoted to the understanding and control of aging. Methuselah Flies: is a tightly edited distillation of twenty years of work by many scientists; contains the original publications regarding the longer-lived fruit flies; offers commentaries on each of the topics covered - new, short essays that put the individual research papers in a wider context; gives full access to the original data; captures the scientific significance of postponed aging for a wide academic audience.

Contents:

CONTENTS; Introduction: Why Methuselah Flies?; References; I CREATION AND LONG-TERM EVOLUTION OF METHUSELAH FLIES; The Creation of Methuselah Flies by Laboratory Evolution; References; LABORATORY EVOLUTION OF POSTPONED SENESCENCE IN DROSOPHILA MELANOGASTER; MATERIALS AND METHODS; RESULTS; DISCUSSION; SUMMARY; ACKNOWLEDGMENTS; LITERATURE CITED; Quantitative Genetics of Postponed Aging in Drosophila melanogaster. I. Analysis of Outbred Populations; MATERIALS AND METHODS; RESULTS; DISCUSSION; LITERATURE CITED

LONG-TERM LABORATORY EVOLUTION OF A GENETIC LIFE-HISTORY TRADE-OFF IN DROSOPHILA MELANOGASTER. I. THE ROLE OF GENOTYPE-BY-ENVIRONMENT INTERACTIONMATERIALS AND METHODS; RESULTS; DISCUSSION; ACKNOWLEDGMENTS; LITERATURE CITED; EVOLUTIONARY PATTERNS AMONG MEASURES OF AGING; INTRODUCTION; MATERIALS AND METHODS; RESULTS; DISCUSSION; REFERENCES; II STRESS RESISTANCE, PHYSIOLOGY, AND AGING; Increasing Stress Resistance Often Postpones Aging; References; RESISTANCE TO ENVIRONMENTAL STRESS IN DROSOPHILA MELANOGASTER SELECTED FOR POSTPONED SENESCENCE; INTRODUCTION; MATERIAL AND METHODS; RESULTS

LITERATURE CITEDSELECTION ON STRESS RESISTANCE INCREASES LONGEVITY IN DROSOPHILA MELANOGASTER; INTRODUCTION; MATERIALS AND METHODS; RESULTS; DISCUSSION; REFERENCES; Metabolic Reserves and Evolved Stress Resistance in Drosophila melanogaster; Introduction; Material and Methods; Results; Discussion; Acknowledgments; Literature Cited; PHYSIOLOGICAL MECHANISMS OF EVOLVED DESICCATION RESISTANCE IN DROSOPHILA MELANOGASTER; Introduction; Materials and methods; Results; Discussion; References; Postponed aging and desiccation resistance in Drosophila melanogaster; 1. Introduction

2. Materials and methods3. Results; 4. Discussion; Acknowledgements; References; III REPRODUCTION, NUTRITION, AND AGING; Reproduction, Nutrition, and Aging; References; Phenotypic plasticity and selection in Drosophila life-history evolution. I. Nutrition and the cost of reproduction; Methods and materials; Results; Discussion; Acknowledgements; References; Metabolic Aspects of the Trade-Off between Fecundity and Longevity in Drosophila melanogaster; Introduction; Material and Methods; Results; Discussion; Acknowledgments; Literature Cited

Phenotypic plasticity and selection in Drosophila life history evolution. 2. Diet, mates and the cost of reproductionIntroduction; Materials and methods; Results; Discussion; Acknowledgements; References; IV GENETICS AND MOLECULAR BIOLOGY OF METHUSELAH FLIES; Genetics and Molecular Biology; References; The effect of superoxide dismutase alleles on aging in Drosophila; Introduction; Materials and methods; Results; Discussion; Acknowledgements; References; Two-dimensional protein electrophoretic analysis of postponed aging in Drosophila; Introduction; Material and methods; Results; Discussion

Acknowledgements

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-88071-X

9786611880712

981-256-722-4

OCLC:

922951937