Physical biology : from atoms to medicine / [edited by] Ahmed H. Zewail.

Format:

Book

Contributor:

Zewail, Ahmed H.

Language:

English

Subjects (All):

Biophysics.

Biochemistry.

Molecular biology.

Physical Description:

1 online resource (582 p.)

Place of Publication:

London ; Hackensack, NJ : Imperial College Press, c2008.

Language Note:

English

Summary:

This is an avant-garde book edited by Nobel Laureate Ahmed Zewail with contributions from eminent scientists including four Nobel prize winners. The perspectives of these world leaders in physics, chemistry, and biology define potential new frontiers at the interface of disciplines and including physical, systems, and synthetic biology.This book brings about the confluence of concepts and tools, and that of different disciplines, to address significant problems of our time: visualization; theory and computation for complexity; macromolecular function, protein folding and misfolding; and system

Contents:

Contents; Prologue by Ahmed H. Zewail; Chapter 1 The Preoccupations of Twenty-First-Century Biology David Baltimore; Chapter 2 The World as Physics, Mathematics and Nothing Else Alexander Varshavsky; Acknowledgments; References; Chapter 3 Physical Biology: 4D Visualization of Complexity Ahmed H. Zewail; 1. Prologue; 2. Visualization: From the Very Small to the Very Big; 3. 4D Electron Microscopy; 4. Applications of 4D Electron Imaging; 4.1. Physics; 4.2. Chemistry; 4.3. Biology; 4.4. Nanoscale Mechanical and Melting Phenomena; 5. Epilogue; Acknowledgments; Selected Publications

Chapter 4 Revolutionary Developments from Atomic to Extended Structural Imaging John Meurig Thomas1. Introduction; 2. Imaging Atoms by Field-Ion Microscopy (FIM); 3. Imaging Atoms and Molecules by Scanning Tunneling Microscopy (STM); 4. Imaging Biological Cells by X-Ray Tomography27,28; 4.1. A Possible New Means of Imaging Cells by Mass Spectrometry; 5. Electron Microscopy: A Veritable Cornucopia of Techniques for Atomic and Extended Structural Imaging; 5.1. Imaging of Extended Inorganic Structures; 5.2. Imaging of Biological Molecules; 6. Electron Tomography (ET)

6.1. Electron Tomography in the Chemical and Materials Sciences6.2. Electron Tomography in the Biological Sciences; 7. Electron-Energy-Loss Spectroscopy (EELS) and Imaging; 8. Time-Resolved Electron Microscopy; 8.1. Ultrafast Electron Microscopy (UEM); 8.2. New Developments in Time-Resolved Structural Studies; Acknowledgments; References; Chapter 5 Physical Biology at the Crossroads Carlos J. Bustamante; 1. Introduction; 2. The Challenges Ahead; 2.1. In Search of a New Thermodynamics; 2.1.1. The cell is not a macroscopic system; 2.1.2. Molecular motors; 2.2. The Study of Self-Assembly

2.3. Towards an Integration of Cell Function2.3.1. Systems biology and synthetic biology; 2.4. Theory and Computation; 2.5. New Methods; 2.5.1. Single-molecule methods; 2.5.2. Ultra-high resolution optical microscopy; 3. Conclusions; References; Chapter 6 The Challenge of Quasi-Regular Structures in Biology Roger D. Kornberg; Acknowledgments; References; Chapter 7 The Future of Biological X-Ray Analysis Douglas C. Rees; 1. Introduction; 2. Structural Analysis of Complex Biological Systems; 3. Structure Determination at Ever Higher Resolution; 4. Structural Dynamics of Macromolecules

5. Concluding RemarksAcknowledgments; References; Chapter 8 Reinterpreting the Genetic Code: Implications for Macromolecular Design, Evolution and Analysis David A. Tirrell; 1. Introduction; 2. Codon Assignment - Interpreting the Genetic Code; 3. Assigning Codons to Non-Canonical Amino Acids - Design of the Cellular Machinery; 3.1. Over-Expression of Wild-Type Synthetases; 3.2. Design of Mutant Synthetases; 3.3. Combinatorial Approaches to Mutant Synthetases; 3.4. Design of Amino Acid Substrates; 4. Non-Canonical Amino Acids in Macromolecular Design, Evolution and Analysis

4.1. Protein Design

Notes:

Description based upon print version of record.

Includes bibliographical references.

ISBN:

9786611866198

9781908978875

1908978872

9781281866196

1281866199

9781848162013

1848162014