Dengue / edited by Scott B. Halstead.

Format:

Book

Contributor:

Halstead, Scott B.

Series:

Tropical medicine ; v. 5.

Tropical medicine : science and practice ; v. 5

Language:

English

Subjects (All):

Dengue.

Dengue viruses.

Physical Description:

1 online resource (506 p.)

Place of Publication:

London : Imperial College Press ; Hackensack, NJ : Distributed by World Scientific Pub., c2008.

Language Note:

English

Summary:

This unique volume presents an up-to-date review of one of the world's major health problems - diseases caused by the four dengue viruses. It begins with an insightful story of the origin of dengue disease outbreaks, including the emergence of severe and fatal dengue hemorrhagic fever. The nature, structure and biology of the four dengue viruses are described, and a major portion of the book is focused on the epidemiology of dengue as a mosquito-borne disease. This is complemented by critiques of existing mosquito control programs by three groups of outstanding authorities. The strongest element of the volume is its comprehensive description of the current understanding of dengue disease pathogenesis, followed by an analysis of the pros and cons of five of the most controversial areas in the field: the WHO DEF case definition, secondary dengue infections, virulent viruses, the role of abnormal T cells and autoimmunity.

Contents:

Contents; Contributors; Preface; Chapter 1 Dengue: Overview and History Scott B. Halstead; Host Range; Geographical Distribution; Disease Burden and Cost; Disease burden; Cost; History; Evolution of dengue viruses; Dengue fever; Other viruses; Introduction of the term "dengue"; Meaning of "dengue"; Dengue hemorrhagic fever; Australia, 1897; Greece; Taiwan; Post-World War II; Causal hypotheses; References; Chapter 2 The Infectious Agent David W. C. Beasley and Alan D. T. Barrett; Classification; Dengue serogroup; Virion Structure and Morphology; Immune Response Induced by Dengue Viruses

Proteins Encoded by the VirusFlavivirus structural proteins; Capsid protein; Envelope proteins; Nonstructural proteins; Replication Strategy; Attachment/entry/fusion/uncoating; Potential receptor molecules; Translation and polyprotein processing; RNA replication; Virion assembly and release; Conclusions; References; Chapter 3 Epidemiology Scott B. Halstead; Introduction; Ecology of Vector Mosquitoes; Aedes aegypti; History of dispersal; Habitat; Bionomics; Daily survival rate, longevity and gonotrophic cycle; Temperature; Feeding behavior; Flight range of vector mosquitoes

Dengue virus - mosquito interactionsMosquito infection dynamics; Extrinsic incubation period; Vector competence; Aedes albopictus; History; Bionomics; Mosquito-virus interactions; Other species of the subgenus Stegomyia; Aedes polynesiensis; Aedes (Stegomyia) of the African continent; Aedes of the subgenus Diceromyia; Aedes of the subgenus Finlaya; Aedes of other subgenera; Infectious Disease Epidemiology of Aedes aegypti-Borne Dengue; Intrinsic incubation period; Mosquito density required for dengue transmission; Household transmission; Basic reproduction number; Herd immunity

Influence of interannual climate variationTransport of vector mosquitoes; Dispersal of the virus; Traveling waves in endemic countries; Importation and spread of dengue viruses; Repeated introductions; Endemic dengue: generation of genetic diversity; Single introductions: generation of genetic diversity; Virus titer and variation in viremic periods; Enhancing antibodies; Preinfection factors and early infection events; Infection parity; Cocirculation of multiple serotypes; An example of spatial and temporal variation in serotype abundance; Founder or stochastic effect

Sylvatic Cycle of Dengue TransmissionReferences; Chapter 4 Resistance to Infection David W. Vaughn, LTC John M. Scherer and Wellington Sun; Introduction; Innate Immunity; Antibody Responses in Natural Infection; Overview; Antibody response and specificity in natural infection; IgG subclasses; Antibodies and protection; Vaccine Development; Introduction; Traditionally attenuated live virus vaccines; Molecularly attenuated live virus vaccines; Chimeric live virus vaccines; DNA/RNA approach; Inactivated whole virus vaccines; Recombinant subunit vaccines; Conclusion; References

Chapter 5 Clinical Features of Dengue Jeremy Farrar

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9781848162297

1848162294

OCLC:

922951782