Metallothioneins in biochemistry and pathology / edited by Paolo Zatta.

Format:

Book

Contributor:

Zatta, Paolo.

Language:

English

Subjects (All):

Cardiovascular system--Diseases--Etiology.

Cardiovascular system.

Liver--Diseases--Etiology.

Liver.

Metallothionein.

Nervous system--Diseases--Etiology.

Nervous system.

Tumors--Etiology.

Tumors.

Physical Description:

1 online resource (336 p.)

Place of Publication:

Hackensack, NJ : World Scientific, c2008.

Language Note:

English

Summary:

Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathologi

Contents:

CONTENTS; List of Contributors; Part I: Metallothionein in Neurological Disorders; 1. Metallothionein Structure and Reactivity Milan Vašák and Gabriele Meloni; 1. Introduction; 3. Structure of Mammalian Metallothioneins; 3.1. Metallothionein-1 and Metallothionein-2; 3.2. Metallothionein-3; 3.3. Metallothionein-4; 4. Reactivity of Metal-Thiolate Clusters; 5. Structure Dynamics; 6. Metallothioneins in Inorganic Pharmacology; References; 2. Gene Structure and Regulation; 2. Thiol Reactivity as a Central Aspect of Metallothionein's Mechanism of Action Wolfgang Maret

1. Introduction to Metallothionein2. The Sulfur Chemistry of Metallothionein; 3. Metallothionein and Cellular Zinc Regulation; 4. From Chemical Activities to Biological Functions of Metallothionein; 5. Integrative Biology of Metallothionein: Regulation of Gene Expression and Cellular Translocations; Acknowledgments; References; 3. Metallothioneins and Neurodegenerative Diseases Silvia Bolognin and Paolo Zatta; 1. Introduction; 2. Alzheimer's Disease; 3. Frontotemporal Dementia; 4. Binswanger's Disease; 5. Parkinson's Disease; 6. Amyotrophic Lateral Sclerosis; 7. Prion Protein Disease

8. ConclusionReferences; 4. Metallothionein and Brain Inflammation Juan Hidalgo; 1. Introduction; 2. Metallothionein-1/Metallothionein-2 Are Differentially Expressed in the Brain; 3. Metallothionein-1/Metallothionein-2 Are Essential for Coping with Brain Damage; 4. Metallothionein-3: A Challenging Protein; 5. Conclusion; Acknowledgments; References; 5. Metallothionein and Autism Sarah E. Owens, Marshall L. Summar and Michael Aschner; 1. Introduction; 2. Autism; 3. Mercury; 4. Critical Overview of Studies Suggesting Metal Disturbances in Austism; 5. Ethylmercury and Autism; 6. Metallothioneins

7. MT and Autism8. MT as Treatment; 9. Significance; 10. Conclusions; Acknowledgments; References; 6. The Role of Metallothionein and Astrocyte-Neuron Interactions in Injury to the CNS Samantha J. Fung, Roger S. Chung and Adrian West; 1. Introduction; 2. MT Expression; 3. MT-I/MT-II Expression in Response to Injury; 4. Expression of MT-III in Response to Injury; 5. MT-I/MT-II Promotes Wound Healing; 6. MT-I/MT-II Act Directly on Neurons; 7. Model of Extracellular MT-I/MT-II Action in CNS Injury; 8. Putative Interaction of MT and Neurons

9. Signaling Through LDL Receptors - A Putative Mechanism of MT-I/MT-II Activity?10. Conclusion; Acknowledgments; References; Part II: Metallothionein in Oncology; 7. Metallothioneins and Oncology Stamatios E. Theocharis; 1. Introduction; 2. MTs and Cancer; 3. MT Expression in Human Neoplasia; 3.1. Head and Neck Cancer; 3.2. Gastrointestinal Cancer; 3.3. Lung Cancer; 3.4. Renal Cancer; 3.5. Urinary Bladder Cancer; 3.6. Breast Cancer; 3.7. Ovarian Cancer; 3.8. Endometrial and Cervical Cancer; 3.9. Prostate Cancer; 3.10. Testicular Cancer; 3.11. Neurological Neoplasia

3.12. Soft Tissue and Bone Neoplasia

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9789812778949

9812778942