Toxicology. Volume 2 : the past, present, and future of basic, clinical and forensic medicine / Rajat Sethi, editor, Chandra Kolli and Delwar Hussain, co-editors.

Format:

Book

Contributor:

Sethi, Rajat, editor.

Kolli, Chandra, editor.

Hussain, Delwar, editor.

Series:

New Developments in Medical Research

New developments in medical research

Language:

English

Subjects (All):

Toxicology.

Physical Description:

1 online resource (321 p.)

Place of Publication:

New York : Nova Biomedical, 2016.

Summary:

This book offers readers an overview of the field of toxicology while incorporating historical context with present day advances. The chapters, written in a style that facilitates the reader's connection of past developments with the present state-of-the-art practices in specific fields of toxicology, provide a detailed coverage of diverse areas in toxicology. The areas of chapters chosen for detailed discussion are characteristic of the overall field and helps to reinforce the basic principles of toxicology. As such, this book will be a valuable resource not only for those scientists in the field of toxicology, but also for those in related fields (e.g., pharmacology, physiology, microbiology, biochemistry, immunology and others). Additionally, this book will be a valuable resource for teaching graduate students in not only toxicology, but also in the related fields above. While this book is not primarily intended as an introductory text for undergraduate students' first exposure to the field of toxicology, it would serve very useful as a text for an advanced undergraduate level biology or chemistry course. The chapters are filled with appropriate tables and figures which help illustrate and reinforce the information in each chapter. The referencing of material cited is carefully prepared and provides links to additional information that will aid the reader in understanding and appreciating the information within the text. The reader will find this book to be of significant depth and breadth so as to meet the needs of many groups of students and established scientists.

Contents:

TOXICOLOGY THE PAST, PRESENT, AND FUTURE OF BASIC, CLINICAL AND FORENSIC MEDICINE VOLUME 2 ; TOXICOLOGY THE PAST, PRESENT, AND FUTURE OF BASIC, CLINICAL AND FORENSIC MEDICINE VOLUME 2 ; Library of Congress Cataloging-in-Publication Data; CONTENTS ; FOREWORD; PREFACE ; Chapter 1 ENVIRONMENTAL TOXICOLOGY: A SCIENTIFIC PERSPECTIVE ON ESTROGEN MEDIATED SIGNALING IN AIR POLLUTION-INDUCED CARDIAC PATHOGENESIS ; ABSTRACT ; INTRODUCTION ; The Past We Know ; SIGNIFICANCE ; BACKGROUND ; Why Investigate the Single Pollutant Effect ; Why Investigate the Ozone Effect

Why Continue to Investigate the Ozone Cardiac Effect Why Study the Gender Differences with Ozone Effect ; Why Study Chronic Ozone Effects ; Status of Hemodynamic Parameters in O3 Exposed Male and Female Wild Type (WT) Mice Prior to Ischemia-Reperfusion (I/R) (Figure 1) ; Status of Anti- and Pro- Inflammatory Proteins in O3 Exposed Male and Female WT Mice Prior to I/R (Figure 2) ; Status of Anti- and Pro- Oxidant Levels in O3 Exposed Male and Female WT Mice Prior to I/R (Figure 3)

Status of Hemodynamic Parameters, Anti- and Pro-Inflammatory Proteins in Male and Female WT Mice Post In-Vivo I/R (Data Not Shown) 1. EVALUATE THE SEX-RELATED DIFFERENCES IN MYOCARDIAL FUNCTION AND INFLAMMATION IN O3 EXPOSED MICE ; a. Effects of O3 on Cardiac Function Prior to In Vivo Ischemia/Reperfusion (Table 1 and Figure 4) ; b. Effects of O3 on Cardiac Function Post In-Vivo Ischemia/Reperfusion (Table 1 and Figure 5)

2. TO ELUCIDATE THE MECHANISTIC CONTRIBUTION OF ESTROGEN RECEPTOR (ER) SIGNALING IN O3-INDUCED PHENOTYPIC CHANGES IN MALE AND FEMALE MICE MODEL EXPOSED TO DIFFERENT DAYS OF O3a. Role of ERα Signaling in O3 Mediated Changes in Cardiac Function in Male and Female Mice ; b. Role of ERβ Signaling in O3 Mediated Changes in Cardiac Function in Male and Female Mice ; Experiment 2c: Role of Estrogen in O3 Mediated Changes in Cardiac Function in Female Mice; Overall Limitations of the Study ; METHODS ; Exposure Protocol ; Exposure Strategy ; Exposure Equipment's ; ACKNOWLEDGMENTS ; REFERENCES

Chapter 2 BASICS OF HAEMATOLOGY: A TOOL FOR TOXICOLOGICAL SCREENING OF BIOACTIVE ABSTRACT ; INTRODUCTION ; The Haematopoietic Stem Cell (HSC) ; Clinical Applications of Haematopoietic Stem Cells ; HAEMATOTOXICITY ; Some Medicines that Cause Serious Haematological Adverse Effects and Disorders ; Haematological Disorders ; Commonly Used Laboratory Tests for Haematology Analysis ; Mean Corpuscular Volume (MCV); Mean Cell Haemoglobin (MCH) ; Mean Corpuscular Haemoglobin Concentration (MCHC) ; COMPONENT AND METHOD ; In Vitro Haematopoietic Clonogenic Assays (CFU-GM Assays) ; METHOD

RELATED DISORDERS AND ETIOLOGY

Notes:

Description based upon print version of record.

Inlcudes bibliographicarl references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed April 28, 2016).

ISBN:

1-63483-819-X