1 option
Excitotoxicity : fundamental concepts, pathophysiology and treatment strategies / Emerson D. Metzger and Keith G. Halsey, editors.
- Format:
- Book
- Series:
- Neuroscience research progress series.
- Neuroscience research progress
- Language:
- English
- Subjects (All):
- Cell death.
- Toxicity.
- Physical Description:
- 1 online resource (117 p.)
- Place of Publication:
- New York : Nova Publishers, 2013.
- Language Note:
- English
- Summary:
- Excitotoxicity is the pathological process in which neurons are damaged and killed by overstimulation of the excitatory neurotransmitter glutamate receptors. Excitotoxicity may be involved in spinal cord injury, stroke, traumatic brain injury, hearing loss (through noise overexposure or ototoxicity) and in neurodegenerative diseases of the central nervous system (CNS) such as multiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease, alcoholism or alcohol withdrawal and especially benzodiazepine withdrawal, and also Huntington's disease. In this book, the authors discuss the fundamental concepts, pathophysiology and treatment strategies of excitotoxicity. Topics include the involvement of glutamate excitotoxicity in Parkinson's disease; the relevance of the excitotoxic process to schizophrenia; the role of glial cells during the regenerative process and possible strategies of treatment to avoid neuronal damage; and an overview of the current concepts related to the intermittent-hypoxia-induced excitotoxicity in obstructive sleep apnea (OSA) disease.
- Notes:
- Description based upon print version of record.
- Includes bibliographical references and index.
- Description based on online resource; title from PDF title page (ebrary, viewed December 9, 2013).
- ISBN:
- 1-62948-486-5
The Penn Libraries is committed to describing library materials using current, accurate, and responsible language. If you discover outdated or inaccurate language, please fill out this feedback form to report it and suggest alternative language.