Molecular imaging : basic principles and applications in biomedical research / Markus Rudin, University of Zurich, Switzerland.

Format:

Book

Author/Creator:

Rudin, M. (Markus), 1953-

Series:

Gale eBooks

Language:

English

Subjects (All):

Molecular probes.

Diagnostic imaging.

Imaging systems in medicine.

Physical Description:

1 online resource (xxiv, 593 pages) : illustrations (chiefly color)

Edition:

2nd ed.

Place of Publication:

London : Imperial College Press, [2013]

Language Note:

English

Summary:

The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume fami

Contents:

Contents; Preface to the First Edition; Preface to the Second Edition; Acknowledgments; 1. Introduction; 1.1 Biomedical Research: Elucidating Molecular Mechanisms of Disease; 1.1.1 Tumorigenesis as a result of multiple mutations; 1.1.2 Pathogenesis in Alzheimer's-type dementia; 1.1.3 Multiple factors causing disease: Multiplexed diagnostic tools; 1.2 The Drug Discovery Process: From Target Validation to Proof-of-Concept in Man; 1.3 Imaging in Biomedical Research; 1.3.1 Diagnostic imaging; 1.3.1.1 Contrast-to-noise ratio and spatial resolution; 1.3.1.2 Quantification

1.3.2 Target-specific or molecular imaging1.3.2.1 Definition: Molecular imaging; 1.3.2.2 Imaging targets; 1.3.2.3 Prerequisites for molecular imaging: Reporter constructs; 1.3.2.4 Prerequisites for molecular imaging: Imaging modalities; 1.3.2.5 Molecular imaging modalities; 1.3.2.6 Comparison of imaging modalities; 1.4 Summary; References; PART 1: METHODOLOGIES; 2. Imaging Techniques; 2.1 X-ray Computed Tomography (CT); 2.1.1 Basic principles of X-rays; 2.1.2 Principles of X-ray CT; 2.1.3 Image representation, spatial resolution, contrast-to-noise ratio; 2.1.4 Animal CT scanners

2.2 Magnetic Resonance Imaging (MRI)2.2.1 Interaction of a nuclear magnetic moment with a static magnetic field; 2.2.2 Classical description of nuclear magnetic resonance spectroscopy (NMR): Bloch equations and relaxation; 2.2.3 The NMR experiment; 2.2.4 Measurement of relaxation rates in FT-NMR; 2.2.4.1 Measurement of the transverse relaxation rate R2; 2.2.4.2 Measurement of the longitudinal relaxation rate R1; 2.2.5 Principles of MRI; 2.2.5.1 Spatial encoding; 2.2.5.2 The k-space concept; 2.2.5.3 Slice selection; 2.2.5.4 Some basic image acquisition modules

2.2.6 Contrast in MRI, signal enhancement by contrast agents2.2.7 In vivo magnetic resonance spectroscopy (MRS); 2.2.7.1 Selecting the volume-of-interest for in vivo MRS; 2.2.7.2 Issues with MRS as molecular imaging modality; 2.2.7.3 Sensitivity enhancement by hyperpolarization of nuclear spin systems; 2.2.8 Animal MRI scanners; 2.3 Nuclear Imaging: Gamma Scintigraphy, Single Photon Emission Computerized Tomography (SPECT); 2.3.1 The gamma camera: projection images; 2.3.2 3D gamma imaging: SPECT; 2.3.3 High resolution SPECT instrumentation; 2.4 Positron Emission Tomography (PET)

2.4.1 Physical principles of PET2.4.2 Image reconstruction; 2.4.2.1 Filtered backprojection; 2.4.2.2 Statistical image reconstruction; 2.4.2.3 3D reconstruction procedures; 2.4.3 High resolution animal PET instrumentation; 2.5 Optical Imaging; 2.5.1 Photon propagation in scattering media; 2.5.1.1 The diffusion equation for light propagation in tissue; 2.5.1.2 Solutions of the diffusion equation; 2.5.2 Planar imaging/reflectance imaging; 2.5.3 Fluorescence tomography; 2.5.4 Non-contact optical tomography; 2.5.5 Instrumentation; 2.6 Ultrasound Imaging; 2.6.1 Principles of ultrasound imaging

2.6.1.1 Introduction, definitions

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9781848168572

1848168578

OCLC:

857066064