Biomedical physics in radiotherapy for cancer / Loredana Marcu, Eva Bezak, Barry Allen.

Format:

Book

Author/Creator:

Marcu, Loredana.

Contributor:

Bezak, Eva.

Allen, Barry.

Language:

English

Subjects (All):

Cancer--Radiotherapy.

Cancer.

Medical physics.

Physical Description:

1 online resource (449 p.)

Place of Publication:

Collingwood, Vic. : CSIRO Pub., 2012.

Language Note:

English

Summary:

Brings together three major disciplines in radiation oncology: radiotherapy physics, radiobiology and clinical trials.

Contents:

Cover; Contents; Foreword; Acknowledgements; Introduction; 1Interactions of radiation with matter; 1.1 Ionising radiation; 1.2 X-rays; 1.2.1 Characteristic X-rays; 1.2.2 Bremsstrahlung radiation; 1.3 Interaction of X-rays with matter; 1.3.1 Linear attenuation coefficient; 1.3.2 Photoelectric effect; 1.3.3 Compton scattering; 1.3.4 Pair production; 1.3.5 Coherent scattering; 1.3.6 Total interaction coefficient; 1.4 Interactions of heavy charged particles with matter; 1.4.1 Bragg peak; 1.4.2 Linear energy transfer (LET); 1.4.3 Stopping power (mass stopping power)

1.4.4 Range of charged particles1.4.5 Bethe-Bloch formula; 1.4.6 Rutherford scattering; 1.4.7 Interactions of electrons with matter; 1.5 Neutron interactions; 1.5.1 Nuclear reactions with neutrons; 1.6 Radioactivity; 1.6.1 Basic definitions; 1.6.2 Quantities and units of radioactivity; 1.6.3 Sources of radionuclides and ionising radiation; 1.7 Radiation quantities and units; 1.7.1 Radiation weighting factors and equivalent dose; 1.7.2 Tissue weighting factors and effective dose; 1.8 The interaction of radiation with cells; 1.9 DNA - the target; 1.10 References; 2Elements of radiobiology

2.1 Target theory2.1.1 Single hit single target theory; 2.1.2 Single hit multiple target theory; 2.1.3 Linear quadratic model; 2.2 Cell survival curves; 2.3 The cell cycle and cellular radiosensitivity; 2.4 Characterisation of radiation damage; 2.4.1 Lethal damage; 2.4.2 Sublethal damage (SLD); 2.4.3 Potentially lethal damage (PLD); 2.5 Loss of reproductive ability in cells; 2.5.1 Clonogenic assay; 2.5.2 Main quantifying factors in radiation biology: LET, RBE, OER; 2.6 Linear energy transfer (LET); 2.6.1 Energy dependence of LET; 2.7 Relative biological effectiveness (RBE)

2.7.1 RBE as a function of LET2.8 The oxygen effect: oxygen enhancement ratio (OER); 2.8.1 The oxygen 'fixation' hypothesis; 2.8.2 Oxygen enhancement ratio (OER); 2.8.3 OER as a function of LET; 2.9 References; 3Elements of radiotherapy physics; 3.1 X-ray and particle generators; 3.1.1 Production of radioisotopes; 3.1.2 Production of X-rays; 3.1.3 X-ray tube; 3.1.4 Accelerators; 3.2 Radiation quantities and units; 3.2.1 Particle fluence; 3.2.2 Energy fluence; 3.2.3 Exposure; 3.2.4 Exposure rate; 3.2.5 Kerma; 3.2.6 Absorbed dose; 3.2.7 Relationship between exposure, kerma and absorbed dose

3.2.8 Electronic equilibrium3.3 Radiation dose measurements; 3.3.1 Ionisation in gases; 3.3.2 Ionisation potential; 3.3.3 Average energy per ion pair, W; 3.3.4 Experimental values of W for gases; 3.3.5 Ionisation in solids; 3.3.6 Bragg-Gray cavity theory; 3.3.7 Spencer-Attix cavity theory; 3.4 Radiation detectors and dosimeters; 3.4.1 Ionisation chamber; 3.5 Determination of absorbed dose; 3.5.1 Absorbed dose in free space; 3.5.2 Absorbed dose in a phantom; 3.5.3 Determination of absorbed dose for megavoltage X-rays

3.5.4 Absorbed dose in the neighbourhood of an interface between different materials

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786613532312

9780643103313

0643103317

9781280128431

1280128437

9780643103306

0643103309

OCLC:

746853301