Kernicterus : Report based on a symposium held at the IX International Congress of Paediatrics / Andrew Sass-Kortsak.

Format:

Book

Conference/Event

Contributor:

Sass-Kortsak, Andrew, Editor.

Conference Name:

International Congress of Paediatrics (9th : 1959 : Montréal, Québec), author.

Series:

Heritage

Language:

English

Subjects (All):

Pediatrics--Congresses.

Pediatrics.

Kernicterus--Congresses.

Kernicterus.

Physical Description:

1 online resource (xi, 221 pages)

Place of Publication:

Toronto : University of Toronto Press, [2020]

Language Note:

In English.

Summary:

The IXth International Congress of Paediatrics selected Kernicterus as one of the major topics for discussion in recognition of the significant advances made in medical knowledge of this problem during the past decades. The discussion, carried on by an international panel of leading clinicians and basic scientists, was lively and informative. Since the Congress the participants have prepared their papers for presentation in book form, providing illustrations and references, and taking account of the newest material pertaining to the subject. In this volume emphasis is laid on the examination of the various etiological factors which may lead to the development of hyperbilirubinemia, and of the factors which then may facilitate the development of secondary brain damage. There is a collaborative effort to present material which will help physicians in the prevention of this condition and in the improvement of their methods of treatment of it. The introductory panel examines the incidence and clinical course of Kernicterus in premature infants and especially the factors, other than immune haemolytic disease, which many lead to the development of it. Other papers provide statistical material on the incidence of Kernicterus of prematurity, re-evaluate concepts of physiological jaundice, report studies of the question of whether hyperbilirubinemia is premature could lead to neurological sequelae in later life, outline the factors which may influence the life span of the red blood cells in the newborn, describe the distribution and the metabolism of bilirubin in the body and the mechanism of its excretion, and give a pathology of Kernicterus in both humans and animals. It is established that the blood levels of bilirubin cannot be relied upon exclusively to indicate the degree of danger of development of Kernicterus.

Contents:

Frontmatter

PREFACE

CONTENTS

CONTRIBUTORS

Introduction

The Incidence of Kernicterus not due to Haemolytic Disease among Premature Babies

Peak Levels of Serum Bilirubin in Normal Premature Infants

Experience with Kernicterus in Premature Infants

The Neurological Sequelae of Hyperbiliruhinaemia of Prematurity

Physiological Jaundice Re-examined

Physiological Mechanisms of Red Blood Cell Destruction

The Life Span of Erythrocytes in the Newborn

The Relationship between Abnormality of Glutathione Metabolism in Erythrocytes from Newborn Infants and the Occurrence of Drug-induced Haemolytic Anaemia

Peculiarities of Erythrocytes of the Newborn

Metabolism of Glutathione by Erythrocytes from Normal Newborn Infants

A Possible Effect of Vitamin K3 on Erythrocyte Metabolism

The Destruction of Red Cells by Antibodies

The Oxygen-Carrying Capacity and Glycolytic Rates of Erythrocytes from Newborn Infants with Erythroblastosis Caused by Rh Incompatibility

The Mechanism of Glucuronide Formation

Studies of Glucuronide Formation

Bilirubin Sulfate

The Effect of Sodium Glucuronate and Glucuronolactone on Bilirubin Conjugation

Factors Influencing the Synthesis of Direct Reacting Bilirubin

Familial Defect of Glucuronidation: in vivo Studies

Conjugated Hyperbilirubinaemia : A Transport

Bilirubin Metabolism in the Foetus

Glucuronide Formation in Pre-Natal and Neonatal Life

Foetal and Neonatal Development of the Glucuronide-Conjugating System

Conclusion

Pathology of Human Kernicterus

Kernicterus in Gunn's Strain of Rats

The in vivo Crystallization of Bilirubin in Hyperbilirubinaemic Infants

Experimental Studies on the Toxicity of Bilirubin

Toxicity of Haeme Pigments in Different Test Systems

Bilirubin Encephalopathy-Cytotoxicity

The Mode of Action of Bilirubin on Mitochondria

The Effects on Premature Infants of Sulfisoxazole in the Neonatal Period

Factors Influencing the Binding of Bilirubin by Albumin

The Effect of Certain Substances on Bilirubin Levels and Occurrence of Kernicterus in Genetically Jaundiced Rats

The Protective Action of Albumin in Bilirubin Toxicity in Newborn Puppies

Notes:

Reprinted in 2018.

Description based on online resource; title from PDF title page (publisher's Web site, viewed 24. Apr 2020)

ISBN:

1-4875-8349-4

9781487583491

OCLC:

1153458811