Multiple myeloma and related serum protein disorders : an electrophoretic guide / Neil S. Harris, William E. Winter.

Format:

Book

Author/Creator:

Harris, Neil S.

Contributor:

Winter, William E.

Language:

English

Subjects (All):

Blood protein electrophoresis.

Blood--Analysis.

Blood.

Physical Description:

1 online resource (162 p.)

Edition:

1st ed.

Place of Publication:

New York, NY : Demos Medical Pub., c2012.

Language Note:

English

Summary:

Multiple Myeloma and Related Serum Protein Disorders is a practical guide to the clinical use of serum and urine electrophoresis and also includes coverage of immunofixation electrophoresis. These techniques are essential in the accurate identification of monoclonal gammopathies and the diagnosis of multiple myeloma and related disorders. Interpretation is often challenging even for the experienced practitioner. Throughout the book the emphasis is on indications and practical aspects of interpreting test results. Particular attention is paid to differentiating false negative and false positive

Contents:

Title; Copyright; Contents; Preface; Contributors; One Introduction to Serum Protein Electrophoresis; Plasma Proteins; Electrophoresis; Monoclonal Immunoglobulins; Clinical Presentation; Immunofixation Electrophoresis; Bibliography of Historic and General Interest; Two Basic Principles of Electrophoresis; Introduction; Voltage/Current Relationships; Electroendosmosis; Capillary Zone Electrophoresis; Reference; Bibliography of general Interest; Three Protein Constituents of Serum; Introduction; Transthyretin; Alpha-1 antitrypsin; Haptoglobin; Alpha-2 macroglobulin; Ceruloplasmin; Transferrin

C3, the third component of complementImmunoglobulin; Acute phase proteins; Serum protein electrophoresis patterns; References; Four Determination of Immunoglobulin Clonality and Quantitation of Specific Serum Proteins; Immunofixation electrophoresis; Quantitation of serum proteins; CRYOGLOBULINS; References; Selected Bibliography for Cryoglobulins; Five Monoclonal Gammopathies; Introduction; Normal Plasma Cell Development; Monoclonal Immunoglobulin Production; Laboratory Evaluation of Patients With Monoclonal Gammopathies; Benign Monoclonal Gammopathies

Monoclonal Gammopathy of Undetermined SignificanceMGUS Epidemiology; Progression of MGUS to a Neoplastic Plasma Cell Dyscrasia; Complications of MGUS; MGUS Immunophenotype; MGUS Summary; Neoplastic Monoclonal Gammopathies; Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Hairy Cell Leukemia; Lymphoplasmacytic Lymphoma (including Waldenstrom macroglobulinemia); Gamma Heavy Chain Disease (Franklin disease); Mu Heavy Chain Disease; Immunoproliferative Small Intestine Disease (alpha heavy chain disease); Extranodal Marginal Zone Lymphoma of MALT lymphoma

Neoplastic Plasma Cell DyscrasiasMultiple Myeloma; End-organ Damage in Multiple Myeloma; Progression of Smoldering Multiple Myeloma to Symptomatic Multiple Myeloma; Multiple Myeloma Staging; Immunophenotype of Multiple Myeloma; Plasma Cell Leukemia; Epidemiology and Clinical Course OF MULTIPLE MYELOMA; Plasmacytomas: Solitary Plasmacytoma of Bone and Extraosseous Plasmacytoma; Monoclonal Immunoglobulin Deposition Diseases; Amyloidosis; Light Chain Deposition Disease; Osteosclerotic Myeloma; Summary; Bibliography; References; Six Urine Protein Electrophoresis; Introduction; Basic Physiology

Mechanisms of ProteinuriaGlomerular Proteinuria and Nonselective Proteinuria; Tubular Proteinuria; Overflow Proteinuria; Combination Patterns; Reporting the Results of UPE; Decision Making in Interpreting UPEs; Summary; References; Bibliography; Seven Capillary Electrophoresis; Introduction; Capillary Tubes; Buffers and pH; Voltage and Migration; Sample Introduction; Clinical Applications; Future Prospects; References; Eight A Clinical Approach to Serum and Urine Electrophoresis; Introduction; Acute Inflammation; Nephrosis; Beta-Gamma Bridging; Polyclonal Hypergammaglobulinemia

Hypogammaglobulinemia

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-280-56943-3

9786613599032

1-61705-015-6

OCLC:

781772751