Bicuspid aortic valve : diagnosis, surgical treatment and complications / Anthony Chapman, editor.

Format:

Book

Contributor:

Chapman, Anthony, editor.

Series:

Congenital disorders: laboratory and clinical research series.

Congenital Disorders - Laboratory and Clinical Research

Language:

English

Subjects (All):

Heart valve prosthesis.

Aortic valve--Stenosis--Surgery.

Aortic valve.

Cardiac catheterization.

Physical Description:

1 online resource (102 p.)

Place of Publication:

New York, [New York] : Nova Biomedical, 2015.

Summary:

Bicuspid aortic valve (BAV) is the most common congenital pathology of the aortic valve occurring in 0.5-2% of the general population and frequently requiring surgical management after the fourth decade of life. From the etiology to the surgical management of BAV is analyzed. Other chapters review genome-wide association studies, linkage analyses and next-generation sequencing studies, which are beginning to build a more comprehensive picture of the genetic bases of BAV. The prospects for developing tools for genetic screening of families and for risk stratification are explored as well, inclu

Contents:

BICUSPID AORTIC VALVE:DIAGNOSIS, SURGICAL TREATMENTAND COMPLICATIONS; BICUSPID AORTIC VALVE:DIAGNOSIS, SURGICAL TREATMENTAND COMPLICATIONS; Library of Congress Cataloging-in-Publication Data; Contents; Preface; Chapter 1:Bicuspid Aortic Valve Syndrome:From the Etiology to the SurgicalStrategies of Treatment; Abstract; Definition and Epidemiology of AorticPathology; Etiopathogenesis of the Aortic Disease; Histology of the Aortic Wall; Anatomic Classification andNatural History; Diagnosis; Surgical Treatment; Discussion; References

Chapter 2:Genetic Influences on Phenotypein Bicuspid Aortic Valve:Screening, Diagnosisand PrognosisAbstract; Introduction; Evidence for Heritability of BAV; Normal Valve Development; Animal Models of BAV; Human Genetic Syndromes; Linkage Analyses; Target Gene Approach -Next Generation Sequencing; Genome-Wide Association Studies(GWAS); Genetic Basis of Thoracic AorticAneurysm (TAA) in BAV; Thoracic Aortic Aneurysm Associated withBAV: Haemodynamic Theory; Genotype-Phenotype Correlations; Phenotype Modifiers - Common Variants; microRNAs: The New Kids on the Block; State of Knowledge; Conclusion

Chapter 3:Genetic Basis, Pathogenesis andHistopathology of Aortopathy inBicuspid Aortic Valve andMarfan syndromeAbstract; Frequency and Possible Causes ofAortic Dilation (Aneurysms); Discussion; Conclusion and Future Directions; Acknowledgments; References; Blank Page; Index

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed August 22, 2015).

ISBN:

1-63482-809-7