Gliomas : classification, symptoms, treatment and prognosis / David Adamson, editor.

Format:

Book

Contributor:

Adamson, David, editor.

Series:

Neuroscience research progress series.

Neuroscience Research Progress

Language:

English

Subjects (All):

Glioma--therapy.

Glioma.

Brain--Tumors.

Brain.

Physical Description:

1 online resource (272 p.)

Place of Publication:

New York, New York : Nova Science Publishers, 2014.

Language Note:

English

Summary:

Gliomas represent some of the most difficult tumors to understand and most challenging to treat. As illustrated in this book, the difficulty in understanding them is apparent in various ways. They have significant diversity in histology, genomic alternations, protein expression, clinical presentation, radiographic appearance, treatment approaches, and ideas of how to cure them. Our current understanding of the genetic mutations and signaling pathways that drive these tumors has greatly expanded our knowledge and at the same time, our uncertainty about how to combat these tumors. Added to this

Contents:

""GLIOMAS: CLASSIFICATION, SYMPTOMS, TREATMENT AND PROGNOSIS""; ""GLIOMAS: CLASSIFICATION, SYMPTOMS, TREATMENT AND PROGNOSIS""; ""Library of Congress Cataloging-in-Publication Data""; ""Contents""; ""Preface""; ""Chapter 1: Classification, Histology, Genomic Alterations and New Therapeutic Concepts""; ""Abstract""; ""Gliomas Histology and Grading""; ""Glioma Genomics""; ""Loss of Heterozygosity in 1p and 19q""; ""IDH1""; ""EGFR""; ""PDGF""; ""PTEN""; ""RB""; ""P53""; ""Treatment""; ""Altered Immune System in Gliomas""; ""Summary""; ""Acknowledgments""; ""References""

""Chapter 2: Brainstem Gliomas""""Abstract""; ""Introduction""; ""Epidemiology""; ""Classification""; ""Pathology and Pathophysiology""; ""Molecular Genetics""; ""Clinical Presentation""; ""Imaging Studies""; ""Diagnosis and Differential Diagnosis""; ""Treatment""; ""Outcomes""; ""Recent Advances and Future Directions""; ""Conclusion""; ""References""; ""Chapter 3: Pediatric Gliomas: Classification, Biology, Treatment and Prognosis""; ""Abstract""; ""Introduction""; ""Conclusion""; ""References""; ""Chapter 4: Minimally Invasive Techniques for the Surgical Treatment of Glioma""; ""Abstract""

""Surgical Goals""""Pre-Operative Planning""; ""Surgical Approach""; ""Intraoperative Tools""; ""Intraoperative Imaging""; ""Complication Avoidance""; ""Conclusion""; ""Acknowledgments""; ""References""; ""Chapter 5: Advances in Targeted Radiation Therapy for High-Grade Gliomas""; ""Abstract""; ""Introduction""; ""Identifying the Target""; ""Delivering Dose to the Target""; ""Conclusion""; ""References""; ""Chapter 6: PET Tracers in Glioma Imaging""; ""Abstract""; ""PET Tracers in Glioma Imaging""; ""Conclusion""; ""References""

""Chapter 7: The Role of Genomic Instability and Tumor Suppressors� Alterations in Glioma Pathogenesis""""Abstract""; ""Introduction""; ""Histopathological Characterization of Gliomas""; ""Molecular Genetics of Malignant Gliomas""; ""Tumor Heterogeneity and Genomic Instability in GBM""; ""The Role of Tumor Suppressor Gene Alterations in GBM""; ""Conclusion""; ""References""; ""Chapter 8: Signaling Pathways and Therapeutic Targets in GBM""; ""Abstract""; ""Abbreviations""; ""Introduction""; ""Tyrosine Kinases in GBM""; ""Signal Transduction Pathways""

""Current Treatment Options for Glioblastoma""""Conclusion""; ""References""; ""Chapter 9: Identification of a Potent Antiglioma Agent from Pre-Clinical Screening""; ""Abstract""; ""Introduction""; ""Conclusion""; ""Acknowledgment""; ""References""; ""Chapter 10: The Relationship between P53-ROS Pathway and Programmed Cell Death in C6 Glioma Cells""; ""Abstract""; ""Abbreviations""; ""Introduction""; ""NAC Induces Apoptosis and Necrosis in C6 Glioma Cells""; ""P53 Participates in the Regulation of Necrosis in C6 Glioma Cells""

""ROS Participate in the Regulation of Necrosis in C6 Glioma Cells""

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-63117-875-X

OCLC:

916950099