Cholangiocarcinoma : from diagnosis to treatment / Dario Ribero and Timothy M. Pawlik, editors.

Format:

Book

Contributor:

Ribero, Dario, editor.

Pawlik, Timothy M., editor.

Series:

Cancer etiology, diagnosis, and treatments.

Cancer Etiology, Diagnosis and Treatments

Language:

English

Subjects (All):

Bile ducts--Cancer--Diagnosis.

Bile ducts.

Bile ducts--Cancer--Treatment.

Physical Description:

1 online resource (477 p.)

Place of Publication:

New York : Nova Biomedical, 2015.

Summary:

Cholangiocarcinoma is a heterogeneous group of neoplasms, which has a rising worldwide incidence. Therefore, it is now a major cause of cancer mortality. Diagnosis, staging, treatment approaches and outcomes differ significantly based on the location of the tumor. Given the challenges of remaining up-to-date in a rapidly expanding field, the aim of this monograph is to provide a comprehensive, fully referenced presentation of the state-of-the-art medical and surgical aspects relevant to the management of cholangiocarcinoma divided by the site of origin (i.e. intrahepatic, hilar and distal). The division of the book into these sections reflects the biological and clinical differences between these tumor types and will permit the authors to address the diagnostic, interventional or treatment issues specific to each tumor type. By presenting all medical and surgical aspects of cholangiocarcinoma in a systematic manner, this monograph will be a ready-to-use instrument for those interested in cholangiocarcinoma, including practicing physicians, residents, fellows and specialists. A list of 66 world-renowned experts contributed to the book, offering the readers the unique opportunity to have a broad perspective on these diseases, practical indications on patient selection and treatment that can be easily applied to both Eastern and Western clinical settings.

Contents:

CHOLANGIOCARCINOMA FROM DIAGNOSIS TO TREATMENT; CHOLANGIOCARCINOMA FROM DIAGNOSIS TO TREATMENT; Library of Congress Cataloging-in-Publication Data; CONTENTS ; PREFACE ; SECTION 1: INTRAHEPATIC CHOLANGIOCARCINOMA ; Chapter 1 EPIDEMIOLOGY OF INTRAHEPATIC CHOLANGIOCARCINOMA ; ABSTRACT ; INTRODUCTION ; GEOGRAPHICAL DISTRIBUTION; RISK FACTORS ; Biliary Factors ; Parasite Infection ; Primary Sclerosing Cholangitis ; Bile Ductal Cystic Disorders ; Biliary Lithiasis ; Non-biliary Factors ; Aging ; Gender ; Racial and Ethnic Variations ; Genetic Variants

Heavy Alcohol Consumption and Tobacco Smoking Chemical Carcinogens ; Environmental Factors ; Metabolic Syndromes ; Liver Diseases ; Inflammatory Bowel Disease ; Other Factors ; LIMITATION AND FUTURE STUDIES ; CONCLUSION ; SUMMARY ; REFERENCES ; Chapter 2 PATHOLOGY OF INTRAHEPATIC CHOLANGIOCARCINOMA; ABSTRACT ; INTRODUCTION ; PATHOLOGICAL FEATURES ; Gross Classification ; Histologic Features ; Conventional ICCs (Bile Duct ICCs) ; Bile Ductular Type ; IG Type ; Rare Variants ; PRENEOPLASTIC AND PREINVASIVE LESIONS OF CCAS ; Flat Type: Biliary Intraepithelial Neoplasm (BilIN)

Papillary Type: Intraductal Papillary Neoplasm of Bile Duct (IPNB) Tubular Type: Intraductal Tubular Neoplasm of Bile Duct (ITNB) ; Cystic Type: Hepatic Mucinous Cystic Neoplasm (h-MCN) ; Others ; BACKGROUND HEPATOBILIARY LESIONS OF ICC ; Chronic Inflammatory Biliary Diseases ; Biliary Tract Malformation and Developmental Disorders; Chronic Advanced, Non-Biliary, Liver Diseases ; Chronic Exposure to Toxins and Chemicals ; OTHERS ; Progression of ICCA with Molecular and Genetic Aspects ; Cellular Senescence in BilIN

Participation of EZH2 and Bmi1 in Escape from p16-Related Cellular Senescence CONCLUSION ; SUMMARY ; REFERENCES ; Chapter 3 MOLECULAR BIOLOGY OF INTRAHEPATIC CHOLANGIOCARCINOMA ; ABSTRACT ; INTRODUCTION ; MOLECULAR PATHOLOGY OF INTRAHEPATIC CHOLANGIOCARCINOMA ; Cellularity and Origin of Intrahepatic CCA ; THE MOLECULAR ALTERATIONS OF INTRAHEPATIC CHOLANGIOCARCINOMA ; Detection of Chromosomal Alterations ; Detection of Somatic Mutations ; Implication of Somatic Mutations Following Deep Sequencing ; IMPLICATION OF EPIGENETIC ABERRATIONS ; DNA Methylation ; Non-Coding RNAs

DEREGULATED NETWORKS IN INTRAHEPATIC CCA The Polo-Like Kinases ; WNT/Hedgehog/Notch Signaling ; JAK/STAT Cytokine Signaling ; The Hippo Signaling Pathway ; CONCLUSION ; SUMMARY ; REFERENCES ; Chapter 4 DIAGNOSTIC IMAGING OF INTRAHEPATIC CHOLANGIOCARCINOMA ; ABSTRACT ; INTRODUCTION ; IMAGING TECHNIQUE ; Ultrasound; Computed Tomography ; Magnetic Resonance Imaging/Magnetic Resonance Cholangiopancreatography ; Positron Emission Tomography ; MASS-FORMING TYPE ; Ultrasound ; Computed Tomography ; Magnetic Resonance Imaging/Magnetic resonance cholangiopancreatography

PERIDUCTAL-INFILTRATING TYPE

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed May 2, 2016).

ISBN:

1-63483-500-X