Field cancerization : basic science and clinical applications / editor, Gabriel D. Dakubo.

Format:

Book

Contributor:

Dakubo, Gabriel D.

Series:

Cancer Etiology, Diagnosis and Treatments

Language:

English

Subjects (All):

Carcinogenesis.

Cancer invasiveness.

Physical Description:

1 online resource (619 p.)

Place of Publication:

Hauppauge, N.Y. : Nova Science, c2011.

Language Note:

English

Summary:

The presence of multiple cancers in one patient has excited the interest of many investigators, and considerable literature has accumulated on this subject. The scientific concepts and clinical importance of field cancerization are the subject matter of this book. This book is a compendium of importance to oncologists and cancer researchers and caregivers. Existent knowledge on cancer biology and therapy has been vastly expanded by this concept of cancer evolution. Expanding "super-competitors", multi-step carcinogenesis, and stem cell theories are some novel mechanistic models of carcinogenesis discussed in this book. Extensively covered in this book as well, are the cellular and molecular changes representative of field cancerisation in several cancers, including haematologic and paediatric cancers.

Contents:

""CANCER ETIOLOGY, DIAGNOSIS AND TREATMENTS""; ""Contents""; ""Preface""; ""Part I - Mechanisms of Field Cancerization""; ""Expanding Supercompetitors as a Mechanism of Field Cancerization""; ""The Multistep Field Cancerization Theory of Carcinogenesis""; ""Development of Tumor Stem Cells: Implication in Field Cancerization""; ""Part II - Epedemiological Aspects of Field Cancerization""; ""Epidemiology of Synchronous and Metachronous Type Multiple Primary Neoplasms""; ""Field Cancerization in Derivatives of the Embryonic Foregut: An Observation Based on Epidemiological Patterns""

""Part III � Clincal and Molecular Aspects of Field Cancerization in Specific Tissues""""Field Cancerization and Oral Leukoplakia""; ""Field Cancerization in Head and Neck Squamous Cell Carcinoma with Focus on Second Primary Tumors""; ""Field Cancerization in Esophageal Epithelia Demonstrated by Telomere Shortening and Chromosomal Instability""; ""Field Cancerization in Mammary Tissues""; ""Field Cancerization in Gastric Cancer""; ""Field Cancerization in Colorectal Cancer""; ""Epigenetic Changes in Hepatic Tissues: Evidence of Field Cancerization""

""Molecular Genetic Alterations in Preneoplastic and Neoplastic Lesions of the Gallbladder""""Field Cancerization in Intraductal Papillary Mucinous Neoplasia of the Pancreas""; ""Field Cancerization in Urothelial Carcinomas of the Upper Urinary Tract""; ""Clonality of Multifocal Urothelial Cancer and Field Cancerization""; ""Evidence of Skin Field Cancerization""; ""Management of Field Cancerization: The Case of Actinic Keratosis""; ""Field Cancerization in Endometrial Carcinoma""; ""Field Cancerization in Vulvar, Vaginal and Cervical Epithelia""; ""Molecular Signatures in Ovarian Cancer""

""Epigenetic Changes in Prostatic Tissues: Evidence of Field Cancerization""""Epigenetic Mechanisms in Solid Tumours of Infancy and Childhood""; ""Epigenetics in Hematological Malignancies""; ""Part IV � Biomarker Development and Therapy Targeting of Epigenetics""; ""Molecular Signatures as Cancer Biomarkers: Methodologic Issues in Discovery, Validation, Qualification, and Standardization""; ""Chemoprevention Targeting Epigenetic Changes in Cancer""; ""Contributors""; ""Index""

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-61761-386-X