Acute myeloid leukemia : signs/symptoms, classification and treatment options / Juan M. Garza, editor.

Format:

Book

Contributor:

Garza, Juan M., editor.

Series:

Cancer etiology, diagnosis, and treatments.

Cancer etiology, diagnosis and treatments

Language:

English

Subjects (All):

Acute myeloid leukemia--Diagnosis.

Acute myeloid leukemia.

Acute myeloid leukemia--Treatment.

Bone marrow--Cancer--Diagnosis.

Bone marrow.

Physical Description:

1 online resource (132 p.)

Place of Publication:

New York, [New York] : Nova Biomedical, 2015.

Summary:

Acute myeloid leukemia (AML) is an aggressive bone marrow cancer associated with high morbidity and mortality and most commonly affects older patient populations. In this book, the clinical presentation of acute myeloid leukemia are presented. Other chapters present the differences in the outcomes of two subtypes of core binding factor (CBF) acute myeloid leukemia (AML); examine the occurrence of the Philadelphia chromosome in AML with core binding factor leukemia; and therapeutic options of older patients with AML.

Contents:

ACUTE MYELOID LEUKEMIA SIGNS/SYMPTOMS, CLASSIFICATION AND TREATMENT OPTIONS ; ACUTE MYELOID LEUKEMIA SIGNS/SYMPTOMS, CLASSIFICATION AND TREATMENT OPTIONS ; Library of Congress Cataloging-in-Publication Data; CONTENTS ; PREFACE ; Chapter 1 CLINICAL PRESENTATION OF ACUTE MYELOID LEUKEMIA ; ABSTRACT ; INTRODUCTION ; INCIDENCE AND PATIENT CHARACTERISTICS ; SYMPTOMS ; ORGAN INVOLVEMENT ; Skin ; Ocular ; Oral ; Central Nervous System ; Cardiovascular ; Pulmonary ; Gastrointestinal ; Lymphoreticular ; Musculoskeletal ; LABORATORY FINDINGS ; Complete Blood Counts ; Coagulation Studies

Electrolytes Leukocyte Larceny ; CLINICAL SYNDROMES ASSOCIATED WITH AML; Leukostasis ; Disseminated Intravascular Coagulation ; Tumor Lysis Syndrome ; Infection ; Extramedullary Disease ; CONCLUSION ; REFERENCES ; Chapter 2 PROGNOSIS OF CORE-BINDING FACTOR ACUTE MYELOID LEUKEMIA ; ABSTRACT ; INTRODUCTION ; Subtypes of CBF AML ; Clinical Prognostic Factors ; Molecular Prognostic Factors ; Cytogenetic Factors ; Minimal Residual Disease ; Other Factors ; CONCLUSION AND FUTURE PERSPECTIVES ; ACKNOWLEDGMENTS; REFERENCES; Chapter 3 PHILADELPHIA CHROMOSOME-POSITIVE ACUTE MYELOID LEUKEMIA

ABSTRACT INTRODUCTION; Differentiating from Blast Phase Chronic Myeloid Leukemia ; ClinicopathologicFeatures ; Management ; Role of Chemotherapy ; Role of Tyrosine Kinase Inhibitors ; Allogeneic Stem Cell Transplantation ; Presence of Additional Abnormalities ; CONCLUSION ; CONFLICT OF INTEREST ; ACKNOWLEDGMENT ; REFERENCES ; Chapter 4 THERAPY OF OLDER PATIENTS WITH ACUTE MYELOID LEUKEMIA; ABSTRACT ; INTRODUCTION ; PROGNOSTIC FACTORS; Patient-Related Prognostic Factors ; Age ; Performance Status ; Comorbidities ; Other Patient-Related Prognostic Factors; Disease-Related Prognostic Factors

WBC Count Cytogenetics ; Molecular Genetics ; Mutations ; Overexpression ; Multidrug Resistance ; Secondary AML ; Other Disease Related Prognostic Factors ; Response-Related Prognostic Factors ; TREATMENT ; Intensive Induction Chemotherapy; The Role of Cytarabine ; The Role of Anthracycline ; The Role of Other Cytotoxic Agents ; The Role of Gemtuzumab Ozogamicin ; The Role of Multidrug Resistance Modulators ; The Role of Growth Factors ; Non-Intensive Induction Chemotherapy ; The Role of BSC ; The Role of Low Dose Cytarabine (LDAC) ; The Role of Clofarabine

The Role of Hypomethylating Agents Azacitidine ; Decitabine ; Postremission Chemotherapy ; CONCLUSION; REFERENCES ; INDEX

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed April 27, 2016).

ISBN:

1-63483-918-8