Brugada syndrome : diagnosis, clinical manifestations, risk stratification and treatment / Gregory Dendramis, editor.

Format:

Book

Contributor:

Dendramis, Gregory, editor.

Series:

Cardiology research and clinical developments series.

Cardiology research and clinical developments

Language:

English

Subjects (All):

Brugada syndrome.

Brugada syndrome--Diagnosis.

Brugada syndrome--Treatment.

Physical Description:

1 online resource (106 p.)

Place of Publication:

New York : Nova Biomedical, 2016.

Summary:

Electrocardiographically characterized by a distinct ST-segment elevation in the right precordial leads, Brugada syndrome (BrS) is an arrhythmogenic disease reported to be responsible for at least 4% of all sudden deaths (at least 20% of sudden deaths in those without structural heart disease), and is a leading cause of death in subjects under the age of forty years. Global prevalence of the BrS varies from 5% to 20% in every 10,000 inhabitants worldwide, and it is considered endemic in Asian and Southeast Asian countries. The diagnosis is mainly based on electrocardiographic features and may be hampered by incomplete penetrance, particularly because of dynamic ECG manifestations. As far as we know, inheritance occurs via an autosomal dominant mode of transmission, and about eighteen genes have been associated with BrS; thus far, genetic abnormalities are found in 30-50% of genotyped BrS patients. Mutations in the cardiac sodium channel gene SCN5A are identified in 11-28% of patients with BrS, with over 300 different mutations of SCN5A having been identified as the list still grows. Because a genotype remains lacking for at least half of BrS probands, a negative genetic test does not rule out BrS. Febrile states, dysionia and many drugs such as vagotonic agents, sodium channel blockers, ?-adrenergic agonists, ?-adrenergic blockers, antidepressants, and alcohol and cocaine toxicity may unmask the electrocardiographic concealed ECG manifestations of BrS. Identifying patients with BrS at risk of malignant arrhythmias and sudden cardiac death remains the most important objective and therefore the fundamental question remains on the best strategy for assessing the real disease-associated arrhythmic risk, especially in asymptomatic patients. The therapeutic approach for patients with BrS is centered on the prevention of cardiac arrest and syncopal events due to ventricular arrhythmias. Lifestyle changes, such as never using drugs that may potentially induce ventricular arrhythmias and an immediate treatment of fever, should be recommended in all patients with diagnosis of BrS. Some drugs have been tested in BrS patients, but controlled data and/or randomized studies proving their real effective have not been performed. Currently, the cornerstone of therapy for the prevention of sudden cardiac death (SCD) is an implantable cardioverter defibrillator (ICD). An accurate individual risk stratification to select patients for ICD implantation should be accurately performed, particularly in asymptomatic patients. Lastly, catheter ablation of the substrate located in the anterior epicardial region of the right ventricular outflow tract may be considered in patients with a history of arrhythmic storms or repeated appropriate ICD shocks. The study of the areas of delayed depolarization in patients with BrS and the procedure of catheter ablation of the substrate located in the anterior epicardial region therefore opens new horizons in regards to the management of patients with extremely frequent ventricular tachycardia/ventricular fibrillation (VT/VF), for patients at high risk who refuse the implantation of an ICD, and for a better prognostic stratification of patients with BrS not classified as high risk for SCD.

Contents:

BRUGADA SYNDROME DIAGNOSIS, CLINICAL MANIFESTATIONS, RISK STRATIFICATION AND TREATMENT ; BRUGADA SYNDROME DIAGNOSIS, CLINICAL MANIFESTATIONS, RISK STRATIFICATION AND TREATMENT ; Library of Congress Cataloging-in-Publication Data; Contents; Preface; Cardiovascular Division, UZ Brussel-VUB, Brussels, Belgium; Acknowledgments; Chapter 1 Definition and Prevalence; Abstract; References; Chapter 2 Genetic Basis of Brugada Syndrome; Abstract; References; Chapter 3 Cellular and Ionic Mechanisms Underlying the Development of the Brugada Phenotype; Abstract; Introduction

Abnormal Expression of Cardiac NeuralCrest Cells and Brugada Syndrome; Brugada Syndrome and the Disease of the Connexome; References; Chapter 4 Diagnosis of Brugada Syndrome; Abstract; Diagnosis of Brugada Syndrome; References; Chapter 5 Modulating - Precipitating Factors and Brugada Phenocopies; Abstract; References; Chapter 6 Clinical Manifestations; Abstract; Institutions; References; Chapter 7 Prognosis and Risk Stratification; Abstract; Risk of Exercise and the Role of Exercise Stress Testing in Brugada Syndrome; Management during Surgery of Patients with Brugada Syndrome

ReferencesChapter 8 TREATMENT OF BRUGADA SYNDROME ; ABSTRACT; TREATMENT OF BRUGADA SYNDROME ; CATHETER ABLATION TO PREVENT VENTRICULAR FIBRILLATION EPISODES IN BRUGADA SYNDROME ; REFERENCES ; LIST OF CONTRIBUTORS ; Index

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

1-63483-959-5