Current immunosuppressive therapy in organ transplantation / [edited by] Huifang Chen, Shiguang Qian.

Format:

Book

Contributor:

Chen, Huifang, editor.

Qian, Shiguang, editor.

Series:

Organ transplantation research horizons

Language:

English

Subjects (All):

Transplantation immunology.

Immunosuppressive agents.

Physical Description:

1 online resource (647 p.)

Place of Publication:

Hauppauge, New York : Nova Science Publishers, Incorporated, [2015]

Summary:

Organ transplantation has revolutionized the treatment for end-stage organ failure. Immunosuppression is still a major approach currently used in the prevention and treatment of allograft rejection. Both editors Dr. Chen and Dr. Qian have been contributing to preclinical evaluation of immunosuppressants for more than 25 years in North America. Experts from the United States, Canada, the United Kingdom, China, Japan, Germany, Sweden, Hungary and Brazil contributed 23 chapters to this book, providing details of immunological basis in transplantation. They also describe six classes of immunosuppressive agents (calcineurin inhibitors, mTOR inhibitors, JAK-STAT inhibitors, antiproliferative agents, costimulation blockers and corticosteroids), as well as ischemia/reperfusion injury treated agents. Additionally, the new development of cell therapy in the induction of transplant tolerance is introduced. This book provides many important references for the research direction of novel immunosuppressants. Readers that will find this book useful include transplant physicians, surgeons, nurses, immunologists, pharmacologists, pharmacists, medical students, residents and trainees in transplantation.

Contents:

Acute Antibody Mediated Rejection (AMR) Chronic Rejection ; Human Leucocyte Antigens and Calculating Immunological Risk Prior to Solid Organ Transplantation ; Tolerance and Immune Regulation ; Tregs ; Myeloid Derived Suppressor Cells ; Mixed Chimerism - A Spectrum from Tolerance to Graft versus Host Disease ; Infection, Malignancy and Monitoring Alloimmunity; Composite Tissue Transplantation; Xenotransplantation ; References ; Chapter 2 Cellular and Humoral Responses in Organ Transplantation; Abstract ; Abbreviations ; Introduction; T Cell Biology in Transplantation

Direct and Indirect Alloantigen Recognition TCR Signal Transduction ; Costimulatory and Inhibitory Signals ; Cytokine Regulation of T Cell Response ; T Cell Response to Allograft ; T Cell-Targeted Therapies for Transplantation ; Tolerance in Transplantation ; Memory T Cells in Transplantation ; B Cell Biology in Transplantation ; B Cells and Antibody Production ; Alloreactive Antibodies; Antibody-Mediated Rejection and Treatments ; Antigen-Presenting B Cells in Transplant Tolerance ; Conclusion ; References

Application of Biological Agents Summary ; References; Chapter 4 Animal Models in Immunosuppression ; Abstract ; Abbreviations ; Introduction ; Rodent Models for Immunosuppression; Organ-Specific Rodent Transplant Models; Rodent Models of Rejection ; Large Animal Models ; Common Large Animal Models ; Costimulation Blockade ; Cell Depletion; Tolerance Strategies ; Studies of Toxicity: Cyclosporine as Paradigm ; References ; Chapter 5 Ethical Issues of Immunosuppressive Drugs Use in Organ Transplantation ; Abstract ; Abbreviations ; Introduction ; Basic Ethical Principles in ISD Treatment

Autonomy

Notes:

Includes index.

Description based on print version record.

ISBN:

1-63482-947-6