Cancer Stem Cells : Philosophy and Therapies / Lucie Laplane.

Format:

Book

Author/Creator:

Laplane, Lucie., author.

Language:

English

Subjects (All):

Cancer cells.

Stem cells.

Cancer--Treatment--Philosophy.

Cancer.

Oncology.

Physical Description:

1 online resource (265 pages) : illustrations

Place of Publication:

Cambridge, MA : Harvard University Press, [2017]

Language Note:

English

Summary:

"An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than treat cancer by aggressively trying to eliminate all cancerous cells--with harmful side-effects for patients--CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells--the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation. To date, researchers have not agreed on the defining feature of CSCs--their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell's relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers."-- Provided by publisher.

Contents:

Frontmatter

Contents

Abbreviations

Introduction

I. Cancer Stem Cells: A New Theory of Cancer

1. Cancer Stem Cells’ Triumph

2. The CSC Theory

II. The Historical Emergence of the CSC Concept and Its Driving Role in Cancers

3. Teratocarcinomas and Embryonic Stem Cells

4. Leukemic and Hematopoietic Stem Cells

III. Debates on CSCs and Stem Cells: What Are They?

5. Origin, Stemness, and Stem Cells: The Meaning of Words

6. Stem Cell Identity

7. If Stemness Is a Categorical or a Dispositional Property, How Can We Cure Cancers?

8. If Stemness Is a Relational or a Systemic Property, How Can We Cure Cancers?

Conclusion

Notes

References

Acknowledgments

Index

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references and index.

Description based on online resource; title from PDF title page (publisher's Web site, viewed Feb. 24, 2017)

ISBN:

9780674969568

0674969561

9780674969582

0674969588

OCLC:

984687038