Age-related macular degeneration : prevalence, risk factors and clinical management / Melanie Carter, editor.

Format:

Book

Contributor:

Carter, Melanie, editor.

Series:

Eye and vision research developments series.

Eye and vision research developments

Language:

English

Subjects (All):

Retinal degeneration--Age factors.

Retinal degeneration.

Physical Description:

1 online resource (111 p.)

Place of Publication:

New York : Nova Biomedical, [2015]

Language Note:

English

Summary:

Age-related macular degeneration (AMD) is the leading cause of blindness in individuals older than 65 years of age. The authors of this book discuss the role of genetics, sunlight, diet, cardiovascular factors, smoking and alcohol as possible risk factors for AMD. Furthermore, the dry form is more common and accounts for about 85-90% of AMD patients in the USA, while Japanese AMD patients predominantely progress to wet-form or polypoidal choroidal vasculopathy (PCV). The function of a serine protein gene, HTRA1, in wet-form AMD patients is explored in detail. Conversely, the final chapter evaluates the therapeutic effects of high omega-3 fatty acids as anti-inflammatory agents in dry AMD patients. The preliminary findings indicate a promising therapeutic regime for dry AMD and perhaps for other retinopathies as well.

Contents:

AGE-RELATED MACULAR DEGENERATION PREVALENCE, RISK FACTORS AND CLINICAL MANAGEMENT ; AGE-RELATED MACULAR DEGENERATION PREVALENCE, RISK FACTORS AND CLINICAL MANAGEMENT ; Contents ; Preface ; Chapter I Overview of Risk Factors for Age-Related Macular Degeneration (AMD) ; Abstract ; Introduction ; Prevalence ; Genetics ; ATP-binding Cassette Rim Protein (ABCR) ; Age-related Maculopathy Susceptibility Protein 2 (ARMS2); Apolipoprotein E (APOE) ; ATP Synthase ; Complement System Genes ; DNA Excision Repair Protein (ERCC6) ; Fibroblast Growth Factor 2 (FGF2) ; Fibulin-5

Hepatic Lipase (LIPC) Lysyl Oxidase-like 1 (LOX1) ; Selectin-P (SELP) ; Serpin Peptidase Inhibitor (SERPING1) ; Serum Peptidase 1 (HTRA1) ; Transferrin (Tr) ; Voltage-Dependent Calcium Channel 3(CACNG3) ; Diet and Cardiovascular Health ; Sunlight ; Smoking ; Alcohol ; Conclusion ; What Are the Major Risk Factors for AMD? ; Modifiable Risk Factors ; References; Chapter II HTRA1 Overexpression Induces the Exudative Form of Age-related Macular Degeneration ; Abstract ; 1. Introduction ; 2. Functional Analysis of the ARMS2/HTRA1 Gene; 3. Choroidal Neovascularization Mouse Model

4. Clinical Importance of HTRA1References ; Chapter III The New Era of Omega-3 Fatty Acids Supplementation: Therapeutic Effects on Dry Age- Related Macular Degeneration; Abstract ; Introduction ; Age-Related Macular Degeneration ; Pathogenesis of Age-Related Macular Degeneration ; Para-Inflammation in Age-Related Macular Degeneration; Omega-3 Polyunsaturated Fatty Acids ; Treatment Options for Age-Related Macular Degeneration; Current Research in Age-Related Macular Degeneration ; Dry Age-Related Macular Degeneration ; Wet Age-Related Macular Degeneration

Observational Studies in Dry AMD Patients Conclusion ; References ; Chapter IV Bibliography ; Index; Blank Page

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on online resource; title from PDF title page (ebrary, viewed May 3, 2016).

ISBN:

1-63483-356-2