Guide to human genome computing / edited by Martin J. Bishop.

Format:

Book

Contributor:

Bishop, M. J. (Martin J.)

Language:

English

Subjects (All):

Human gene mapping--Data processing.

Human gene mapping.

Human gene mapping--Computer network resources.

Nucleotide sequence--Data processing.

Nucleotide sequence.

Nucleotide sequence--Computer network resources.

Physical Description:

1 online resource (321 p.)

Edition:

2nd ed.

Place of Publication:

San Diego : Academic Press, c1998.

Language Note:

English

Summary:

The Guide to Human Genome Computing is invaluable to scientists who wish to make use of the powerful computing tools now available to assist them in the field of human genome analysis. This book clearly explains access and use of sequence databases, and presents the various computer packages used to analyze DNA sequences, measure linkage analysis, compare and align DNA sequences from different genes or organisms, and infer structural and functional information about proteins from sequence data.This Second Edition contains completely updated material. Rather than a revision of the pr

Contents:

Front Cover; Guide to Human Genome Computing; Copyright Page; Contents; Contributors; Preface; Chapter 1. Introduction to Human Genome Computing Via the World Wide Web; 1 Introduction; 2 Equipment for the tour; 3 Genome databases; 4 Analytic tools; 5 Conclusion; 6 URLs; Chapter 2. Biological Materials and Services; 1 Introduction; 2 Genomic resources available; 3 Chromosome-specific libraries; 4 CpG island libraries; 5 cDNA libraries; 6 Probe and primer banks; 7 Cell lines; 8 Cell hybrid panels; 9 Backcross panels; Chapter 3. Managing Pedigree and Genotype Data; 1 Introduction; 2 Fundamentals

3 Modelling the domain4 Implementing the database; 5 Interfacing with analysis programs; 6 Displaying and managing data; 7 Further development; Chapter 4. Linkage Analysis Using Affected Sib-Pairs; 1 Introduction; 2 Genetic identity-by-descent between sib-pairs; 3 Genetic identity-by-descent and recombination fraction; 4 Identity-by-descent distribution for an affected sib-pair; 5 Methods of affected sib-pair analysis; 6 Affected sib-pair analysis: strengths and limitations; 7 Conclusion; List of computer programs; Chapter 5. Comparative Mapping in Humans and Vertebrates

1 Conservation of genes2 Conservation of linkage groups; 3 Value of comparative mapping; 4 Single-species databases; 5 Protein families; 6 Comparative mapping databases; Chapter 6. Radiation Hybrid Mapping; 1 Introduction; 2 Background; 3 RH mapping concepts; 4 Radiation hybrid mapping programs; 5 Conclusions; Chapter 7. Sequence Ready Clone Maps; 1 Introduction; 2 Strategy; 3 Software for sequence ready maps; 4 Long-range map construction (SAM, Z-RHMAPPER); 5 STS-content data storage using ACEDB; 6 Sequence ready contig construction using FPC; 7 Process tracking and coordination

8 ConclusionsChapter 8. Software for Human Genome Sequencing; 1 Introduction; 2 Overview; 3 Gel image processing; 4 Sequence preprocessing; 5 Sequence assembly; 6 Editing and finishing; 7 Feature identification; 8 Quality control; 9 The finished sequence; 10 Conclusion; 11 Finding software on the Web; Chapter 9. Human EST Sequences; 1 Introduction; 2 Background; 3 Generation of the EST data; 4 Reasons for EST sequencing; 5 Publicly available EST data; 6 EST analysis tools; 7 Biological resources; 8 WWW resources for ESTs; 9 Summary; Chapter 10. Prediction of Human Gene Structure

1 Introduction2 Genome structure; 3 Approaches to evaluate prediction accuracy; 4 Functional sites in nucleotide sequences; 5 Functional regions in nucleotide sequences; 6 Protein coding gene structure prediction; 7 Analysis of potential proteins coded by predicted genes; 8 RNA-coding gene structure prediction; 9 Sequence analysis; Chapter 11. Gene Finding: Putting the Parts Together; 1 Introduction; 2 Dynamic programming; 3 State models; 4 Performance comparison; 5 Conclusion; Chapter 12. Gene-Expression Databases; 1 Introduction; 2 The scope of gene-expression databases

3 A survey of gene-expression data

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-04630-2

9786611046309

0-08-053270-5

OCLC:

476104045