Lipid nanocarriers in cancer diagnosis and therapy [electronic resource] / edited by Eliana B. Souto.

Format:

Book

Contributor:

Souto, Eliana B.

Language:

English

Subjects (All):

Nanomedicine.

Cancer--Diagnosis.

Cancer.

Cancer--Treatment.

Physical Description:

1 online resource (582 p.)

Place of Publication:

Shrewsbury, Shropshire : iSmithers, 2011.

Summary:

This book introduces fundamental principles of lipid nanocarriers science relevant to cancer therapy. The first in this field, it fills a need for an accurate, coherent and authoritative introduction to lipid nanocarriers focusing in cancer therapy; both because of the growing popularity of these modern drug delivery systems and also because of the emergent need of dealing with cancer treatment. Active drug delivery and targeting using nanobiotechnologies has become one of the most successful strategies to approach chemotherapy. This book deals with lipid nanocarriers for targeted delivery to

Contents:

Preface; CONTENTS; Contributors; 1 Reviewing the Gaps in the Safety and Risk Assessment of Nanoparticles and Nanomaterials; 1.1 Introduction; 1.2 Risk Assessment and Sustainability; 1.3 Conclusions; References; 2 Lipid Nanoparticles in Cancer Therapy: Past, Present and Future; 2.1 Introduction; 2.2 Concepts and Definitions of Lipid Nanoparticles; 2.3 In Vitro Properties and In Vivo Features of Lipid Nanoparticles; 2.4 Lipid Nanoparticles for Cancer Chemotherapeutics; 2.5 Conclusions; References; 3 Multifunctional Lipid Nanocarriers for Cancer Prevention and Therapy; 3.1 Introduction

3.2 Lipid-based Nanotechnology for Cancer3.3 Illustrative Examples in Cancer Prevention; 3.4 Illustrative Examples in Cancer Therapy; 3.5 Illustrative Examples of Lipid Nanocarriers for NucleicAcid Delivery; 3.6 Conclusions; Acknowledgements; References; 4 Targeting Solid Lipid Nanoparticles for Drug Delivery inCancer Therapy; 4.1 Introduction; 4.2 Chemotherapy and Its Limitations; 4.3 Solid Lipid Nanoparticles; 4.4 Modifications to Improve Encapsulation Efficiency andRelease Characteristics; 4.5 Modifications to Improve Multidrug Resistance

4.6 Modifications to Improve Cellular Uptake and Targetability4.7 Modifications to Achieve Brain Targeting; 4.8 Toxicity Concerns; 4.9 Conclusions; References; 5 Targeting Liposomes for Drug Delivery in Cancer Therapy; 5.1 Introduction; 5.2 Types of Liposomal Anti-cancer Drugs and Their Clinical Use; 5.3 Ligand-mediated Targeting Liposomes; 5.4 Future Directions of Liposome-based Anti-cancer Drugs; 5.5 Conclusions; Acknowledgements; References; 6 Cationic Liposomes and Tumour Vasculature Targeting:A Therapeutic Approach that has Potential for Solid Tumours; 6.1 Introduction

6.2 Tumour Cell Targeting versus Tumour Vasculature Targeting6.3 Tumour Angiogenesis; 6.4 Tumour Vascular Targeting with Cationic Liposomes; 6.5 Dual Targeting Approach of Both Tumour Endothelial Cellsand Tumour Cells; 6.6 Effect of Sequential Administration on the Anti-tumourEfficacy of Cationic Liposomal Formulations; 6.7 Clinical Applications of Cationic Liposomes: Promise andObstacles; 6.8 Conclusions; Acknowledgements; References; 7 Lipid-based Nanocarriers for Cancer Gene Therapy; 7.1 Introduction; 7.2 Preclinical Studies Testing Lipid-based Nanocarriers forCancer Gene Therapy

7.3 Clinical Studies Testing Lipid-based Nanocarriers for CancerGene Therapy7.4 Conclusions; Acknowledgements; References; 8 Lipid-based Biomimetics: General Perspectives in Drug andVaccine Delivery; 8.1 Introduction; 8.2 Intermolecular Interactions; 8.3 Carriers in the Biological Milieu; 8.4 Lipid Coating on Particles and Its Applications; 8.5 Conclusions; References; Acknowledgements; 9 Advances in Liposomal Formulations for TargetingLung Cancer; 9.1 Introduction; 9.2 Targeting Lung Cancer Cells; 9.3 Lipid-based Targeted Therapies; 9.4 Therapeutic Agents Delivered by Liposomes

9.5 Clinical Use of Liposomes for Lung Cancer

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-280-12523-3

9786613529091

1-84735-479-3

OCLC:

751962261