Nanomaterials : evolution and advancement towards therapeutic drug delivery. Part I / edited by Surendra Nimesh, Nidhi Gupta & Ramesh Chandra.

Format:

Book

Contributor:

Nimesh, Surendra.

Gupta, Nidhi (Research scientist)

Chandra, Ramesh, 1957-

Language:

English

Subjects (All):

Drug delivery systems.

Nanostructured materials.

Physical Description:

1 online resource (321 pages)

Place of Publication:

Sharjah : Bentham Science Publishers, 2021.

Summary:

"The development of a vector for the delivery of therapeutic drugs in a controlled and targeted fashion is still a major challenge in the treatment of many diseases. The conventional application of drugs may lead to many limitations including poor distribution, limited effectiveness, lack of selectivity and dose dependent toxicity. An efficient drug delivery system can address these problems. Recent nanotechnology advancements in the biomedical field have the potential to meet these challenges in developing drug delivery systems. Nanomaterials are changing the biomedical platform in terms of disease diagnosis, treatment and prevention. Nanomaterials aided drug delivery provides an advantage by enhancing aqueous solubility that leads to improved bioavailability, increased resistance time in the body, decreased side effects by targeting drugs to the specific location, reduced dose dependent toxicity and protection of drugs from early release. In this two-part book, the contributors have compiled reports of recent studies illustrating the promising nanomaterials that can work as drug carriers which can navigate conventional physiological barriers. A detailed account of several types of nanomaterials including polymeric nanoparticles, liposomes, dendrimers, micelles, carbon nanomaterials, magnetic nanoparticles, solid lipid-based nanoparticles, silica nanomaterials and hydrogels for drug delivery is provided in separate chapters. The contributors also present a discussion on clinical aspects of ongoing research with insights towards future prospects of specific nanotechnologies. Part II covers the following topics: Solid lipid nanoparticles and nanostructured lipid carriers; Silica based nanomaterials; Hydrogels; Metallic nanoparticles; Computational and experimental binding interactions of drug and β-cyclodextrin; Clinical milestones in nanotherapeutics; Drug delivery systems based on poly(lactide-co-glycolide) and its copolymers. The book set is an informative resource for scholars who seek updates in nanomedicine with reference to nanomaterials used in drug delivery systems.".

Contents:

Cover

Title

Copyright

Contents

Foreword

Preface

List of Contributors

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery Applications

Gabriel Silva Borges1, Mariana Silva Oliveira1, Délia Chaves Moreira dos Santos1, Lucas Antônio Miranda Ferreira1 and Guilherme Carneiro2,*

INTRODUCTION

BACKGROUND

COMPOSITION OF SLN AND NLC

Lipids

Surfactants

Other Components

METHODS FOR SLN AND NLC PRODUCTION

Hot or Cold Homogenization Technique

High Pressure Homogenization (HPH)

Ultrasonication

O/W Microemulsion

Emulsification-Solvent Evaporation

Solvent Injection Method

Multiple Emulsion

Membrane Contactor Method

Super Critical Fluid Technique

Drug Distribution in Lipid Nanocarriers

Strategies for Improving Encapsulation of Drugs in Lipid Nanoparticles

PHYSICOCHEMICAL CHARACTERIZATION

Particle Size

Dynamic Light Scattering

Laser Diffraction

Scanning Ion Occlusion Spectroscopy

Zeta Potential

Crystallinity and Polymorphism

Differential Scanning Calorimetry

X-ray Diffraction

Particle Shape and Morphology

Drug Encapsulation Efficiency and Drug Loading

Soluble in Aqueous Medium

Precipitated

Total Drug Concentration

COMMON PROBLEMS IN SLN AND NLC

Gelation

Supercooled Melts

Coexistence of Nanostructures

MAIN APPLICATIONS OF SLN AND NLC IN PHARMACEUTICS

Administration Routes

Dermal Route

Oral Route

Pulmonary Route

Intravenous Administration

Intranasal Delivery

Ophthalmic Delivery

Important Applications of SLN and NLC

Cancer

Brain Delivery

CONCLUSION

CONSENT FOR PUBLICATION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

REFERENCES

Silica Based Nanomaterial for Drug Delivery.

Charu Bharti1, Md. Sabir Alam2, Md. Noushad Javed3, Muhammed Khalid Saifullah4, Faisal A. Almalki4 and Romila Manchanda5,*

CHEMISTRY OF MESOPOROUS SILICA NANOPARTICLES

CHARACTERISTICS OF MSNS

CHARACTERIZATION TECHNIQUES USED FOR MSNS

FT-IR Spectra

Electron Microscopy

METHODS OF PREPARATION OF MSNS

Stober Process

Evaporation Induced Assembly Synthesis

Combustion Synthesis Process

Aerosol Decomposition Synthesis

Chemical Vapour Deposition

Photothermal Synthesis

Inert Gas Condensation

SURFACE FUNCTIONALIZATION OF SILICA NANOPARTICLES BY VARIOUS METHODS

Co-condensation Method

Post-synthetic Grafting

BIOCOMPATIBILITY AND BIO-DISTRIBUTION

Impact of Size and Shape of the Particle

Impact of Surface Properties

APPLICATIONS OF MSNS

MSNs as siRNA Delivery Vehicles for Cancer Therapy

Gene Delivery / Drug Delivery Using MSNs

Bio-medical Imaging

The Imaging Capability of MSNs in Biomedical

Controlled Release of Bioactive Molecules

Green Chemistry Application of MSNs

Protein Adsorption and Separation

Vascular Targeting/ Passive Targeting

PATENTED CITATION OF MESOPOROUS SILICA NANOPARTICLES

Hydrogels for Drug Delivery

Reena Singh1, Rahul Goel1, Seema Gupta2,* and Pradeep Kumar1,*

POLYMER-BASED HYDROGELS

Natural Polymer-based Hydrogels

Chitosan-based Hydrogels

Gelatin-based Hydrogels

Hyaluronic Acid-Based Hydrogels

Pullulan-Based Hydrogels

An Alginate-Based Hydrogel

Protein-Based Hydrogel

Synthetic Polymer-Based Hydrogels

Polyethylene Glycol (PEG)-Based Hydrogels

Thermally Insulated Hydrogel

Polylactic Acid (PLA)-Based Hydrogels

Polyvinyl Alcohol (PVA)-Based Hydrogel

Polyacrylic Acid-Based Hydrogels.

Polyglutamic Acid-Based Hydrogels

Poloxamer Based Hydrogel

Polylysine-Based Hydrogel

PEPTIDE-BASED HYDROGELS

RADA-16-Based Hydrogels

β-Amino Acid Peptide-Based Hydrogel

Other Miscellaneous Polypeptide Based Hydrogels

FUTURE PERSPECTIVES

Metallic Nanoparticles: Applications in Drug Delivery

Monisha Singhal1, Nidhi Gupta1 and Jyoti Dasharath Magare2,*

ADVANTAGES OF NANOPARTICLES-BASED DRUG DELIVERY

APPLICATIONS

METALLIC NANOPARTICLES

History

Characteristic Properties

GOLD NANOPARTICLES

Methods for the Synthesis of AuNPs

Chemical Method

Physical Methods

Green Methods

Biological Methods

Application of AuNPs

AuNPs as Drug Delivery on Various Diseases

AuNPs as Drug Delivery Vehicle for the Therapy of Metabolic Diseases

AuNPs as Drug Delivery Vehicles for Anti-infective Agents

AuNPs as Drug Delivery on Cancer

AuNPs as the Delivery of Gene

SILVER NANOPARTICLES

Methods for the Synthesis of AgNPs

Physical Method

Green Method

Biological Method

Application of AgNPs

AgNPs for Drug Delivery in Various Diseases

AgNPs in Wound Healing

AgNPs Impregnated on Catheters

AgNPs as Antimicrobials

AgNPs as a Tool for Sensing Applications

METAL OXIDE NANOPARTICLES

Zinc Oxide Nanoparticles

Iron Oxide Nanoparticles

Titanium Oxide Nanoparticles

Cerium Oxide Nanoparticles

Copper Oxide Nanoparticles

Silicon Dioxide or Silica Nanoparticles

Computational and Experimental Binding Interactions of Drug and β-Cyclodextrin as a Drug-Delivery Vehicle

Chandrabose Selvaraj* and Sanjeev Kumar Singh*

INTRODUCTION.

Chronological Evolution of Cyclodextrin

COMPLEX FORMATION IN CYCLODEXTRIN

Physical Blending

Slurry Complexation

Kneading Technique

Co-Precipitation Method

Spray-Drying Method

Microwave Irradiation Method

Milling or Co-Grinding Method

Mechanism of Drug Release from Cyclodextrin Complex

CYCLODEXTRIN BASED SUPRAMOLECULAR VESICLES

SHAPE AND CHEMISTRY OF CYCLODEXTRIN

PROPERTIES OF CYCLODEXTRINS

Computational findings of Drug-β-Cyclodextrin Inclusion Complex

Docking Studies on β-cyclodextrin

Cyclodextrin Based Anticancer Drugs

Cyclodextrin as Pharmaceutical Excipients

Pharmaceutical Applications of Cyclodextrin

Bioavailability Enhancement

Active Stabilization

Irritation Reduction

CYCLODEXTRIN DERIVATIVES

Hydrophilic Derivatives

Hydroxyalkyl Derivatives

Sulfated Cyclodextrins

Hydrophobic Derivatives

EXPERIMENTAL VERIFICATION IN DRUG-Β- CYCLODEXTRIN INCLUSION COMPLEX

Thermal Analytical Technique

Spectroscopy Studies

Visible and Ultraviolet (Uv) Spectroscopy

Scanning Electron Microscope

DRUG RELEASE IN DRUG-CYCLODEXTRIN

SYNTHESIS OF CYCLODEXTRIN

PRODUCTION OF CYCLODEXTRIN

Solvent Process

SUCCESS OF BETA- CYCLODEXTRIN

CHALLENGES AND FUTURE PERSPECTIVES

Clinical Milestones in Nanotherapeutics: Current Status and Future Prospects

Ravi Goyal1, Rupinder K. Sodhi2,* and Jitender Madan2

DRUG TARGETING

CARRIERS FOR NANOTHERAPEUTIC FORMULATIONS

Solid Lipids Nanoparticles

Polymeric Nanoparticles

Nanoliposomes

Micelles

Dendrimers

Nanosuspensions

Carbon Nanotubes

Fullerenes

Magnetic Nanoparticles

NANOTHERAPEUTICS IN CANCER

Cancer Imaging

Chemotherapeutics

Nanoliposomal Formulations.

Albumin-Bound Formulations

Polymer-Bound Formulations

Inorganic Nanoparticle Formulations

Dendrimer Formulations

Carbon Nanotubes Formulations

Gold-based Nanoparticle Formulation

NANOTHERAPEUTICS IN CNS DISORDERS

Alzheimer's Disease

Parkinson's Disease (PD)

Multiple Sclerosis

Amyotrophic Lateral Sclerosis (known as Lou Gehrig's Disease)

Stroke

HIV-1-Associated Neurocognitive Disorders (HAND)

Prions Disease

NANOTHERAPEUTICS IN CARDIAC DISEASES

Imaging of Cardiovascular Diseases

Treatment of Cardiovascular Diseases

NANOTHERAPEUTICS IN INFECTIONS

NANOTHERAPEUTICS IN OCULAR DRUG DELIVERY

NANOTHERAPEUTICS IN RHEUMATOID ARTHRITIS

NANOTHERAPEUTICS IN THYROID

NANOTHERAPEUTICS IN VACCINES

SAFETY OF NANOTHERAPEUTICS

FUTURE PROSPECTS

REFEREENCES

Scale-up, Preclinical and Clinical Status of Poly (Lactide-Co-Glycolide) and its Copolymers based Drug Delivery Systems

Neha Bajwa1, Preet Amol Singh1, Kiran Jyoti2, Ashish Baldi1, Ramesh Chandra3,4 and Jitender Madan2,*

CHEMISTRY AND PHYSICO-CHEMICAL PROPERTIES OF PLGA

PLGA Synthesis

Physicochemical Properties of Poly (Lactide-Co-Glycolide)

Solubility

Crystallinity

Thermal Stability

Mechanical Property

BIODEGRADATION, BIOCOMPATIBILITY, AND TOXICITY OF POLY (LACTIDE-CO-GLYCOLIDE)

Biodegradation Pathway

Biocompatibility

Toxicology

POLY (LACTIDE-CO-GLYCOLIDE) AND ITS COPOLYMERS BASED DRUG DELIVERY SYSTEMS

Microparticle Preparation Techniques

Method of Solvent Evaporation

Phase Separation Coacervation Method

Spray Drying

Nanoparticles Preparation Techniques

Implant Preparation Techniques

Solvent-Casting and Compression Molding

Extrusion.

GelsConstruct Preparation Technique.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

9781681088235

1681088231

OCLC:

1257084331