Handbook of immunological properties of nanomaterials / editors, Marina A. Doborovolskaia, Scott E. McNeil.

Format:

Book

Contributor:

Doborovolskaia, Marina A.

McNeil, Scott E.

Series:

Frontiers in nanobiomedical research ; v 1.

Frontiers in nanobiomedical research, 2251-3965 ; v. 1

Language:

English

Subjects (All):

Nanostructured materials--Health aspects.

Nanostructured materials.

Nanostructured materials--Handbooks, manuals, etc.

Nanotechnology--Health aspects.

Nanotechnology.

Biomedical materials--Toxicology.

Biomedical materials.

Physical Description:

1 online resource (721 p.)

Edition:

1st ed.

Place of Publication:

Hackensack, N.J. : World Scientific, 2013.

Language Note:

English

Summary:

The Handbook of Immunological Properties of Engineered Nanomaterials provides a comprehensive overview of the current literature, methodologies, and translational and regulatory considerations in the field of nanoimmunotoxicology. The main subject is the immunological properties of engineered nanomaterials. Focus areas include interactions between engineered nanomaterials and red blood cells, platelets, endothelial cells, professional phagocytes, T cells, B cells, dendritic cells, complement and coagulation systems, and plasma proteins, with discussions on nanoparticle sterility and sterilizat

Contents:

Contents; Preface; List of Contributors; Chapter 1 Immunological Properties of Engineered Nanomaterials: An Introduction Marina A. Dobrovolskaia and Scott E. McNeil; 1. Introduction; 2. Interaction with Blood Components; 2.1. Hemolysis; 2.2. Coagulation; 2.3. Complement activation; 3. Nanoparticle Uptake by Phagocytic Cells; 4. Immunogenicity; 4.1. Inflammation; 4.2. Antigenicity; 4.3. Adjuvant properties; 5. Immunosuppression; 6. Designing Immunotoxicity Studies; 7. Future Directions; References

Chapter 2 Importance of Physicochemical Characterization Prior to Immunological Studies Jeffrey D. Clogston and Anil K. Patri1. Introduction; 2. Key Parameters that Influence Nanomaterial Immunological Properties; 3. Instrumentation for Physicochemical Characterization; 4. Methodologies for Nanomaterial Separation; 5. A Closer Look; 5.1. Dynamic light scattering; 5.1.1. Additional considerations for DLS measurements; 5.2. Zeta potential; 6. Summary; References; Chapter 3 Impact of Nanoparticle Sterilization on Analytical Characterization Nanda Subbarao; 1. Introduction

2. Why Is Sterilization a Challenge for Nanotherapeutics?3. Previous Studies Reviewing the Effects of Various Sterilization Procedures on Nanomaterials; 4. Available Methods for Sterilization; 4.1. Autoclaving; 4.1.1. Impact on NT analytics; 4.2. Filtration; 4.2.1. Impact on NT analytics; 4.3. Gamma irradiation; 4.3.1. Gamma irradiation of SLNs; 4.3.2. Gamma irradiation and liposomes; 4.3.3. Mitigating the effects of gamma irradiation; 4.3.4. Gamma irradiation remains a method of choice for NTs; 4.3.5. Impact on NT analytics; 4.4. Gaseous ethylene oxide; 4.4.1. Impact on NT analytics

4.5. High hydrostatic pressure sterilization4.6. Formaldehyde; 5. Comparison of Different Methods for Sterilization; 6. Impact on Nanotherapeutic Analytics; 7. Conclusions; References; Chapter 4 Endotoxin and Engineered Nanomaterials Marina A. Dobrovolskaia and Scott E. McNeil; 1. Introduction; 2. What Endotoxin Is and Why It Is Important to Study in Nanoformulations; 3. Methods Used for Endotoxin Detection and Quantification; 3.1. Traditional methods; 3.2. Alternative methods; 3.2.1. Gel-staining-based methods; 3.2.2. Ligand binding-based methods; 3.2.3. Mass spectrometry-based methods

3.2.4. Macrophage activation test4. Estimating Endotoxin in Nanoformulations; 4.1. Nanoparticle interference with traditional methods; 4.2. Evaluation of interference; 4.3. How to choose an appropriate LAL format; 4.4. Application of non-traditional methods; 4.4.1. Gel-based assay; 4.4.2. Western blot-based assay; 5. Use of Traditional Endotoxin-Neutralizing Reagents in Nanoparticle Research; 5.1. Case study 1; 5.2. Case study 2; 6. Minimizing Contamination and Interference; 7. Purification and Depyrogenation of Nanoformulations; 8. Conclusions and Future Directions; References

Chapter 5 Surface Adsorbates on Nanomaterials and Their Possible Roles in Host Inflammatory and Toxicological Processing Clinton F. Jones, David G. Castner, and David W. Grainger

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-62870-227-3

981-4390-26-7

1-299-13310-X

OCLC:

828792689