Principles of tissue engineering / edited by Robert Lanza, Robert Langer, Joseph Vacanti.

Format:

Book

Contributor:

Lanza, Robert, 1956-

Langer, Robert S.

Vacanti, Joseph.

Series:

Tissue Engineering Intelligence Unit

Language:

English

Subjects (All):

Animal cell biotechnology.

Tissue engineering.

Transplantation of organs, tissues, etc.

Physical Description:

1 online resource (1344 p.)

Edition:

3rd ed.

Place of Publication:

Amsterdam ; Boston : Elsevier Academic Press, c2007.

Language Note:

English

Summary:

First published in 1997, Principles of Tissue Engineering is the widely recognized definitive resource in the field. The third edition provides a much needed update of the rapid progress that has been achieved in the field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world's experts of what is currently known about each specific organ system. This edition includes greatly expanded focus on stem cells, including adult and embryonic

Contents:

Front cover; PRINCIPLES OF TISSUE ENGINEERING; Copyright page; CONTENTS IN BRIEF; Table of contents; CONTRIBUTORS; FOREWORD; PREFACE; PREFACE TO THE SECOND EDITION; PREFACE TO THE FIRST EDITION; Introduction to Tissue Engineering; Chapter One: The History and Scope of Tissue Engineering; I. INTRODUCTION; II. SCIENTIFIC CHALLENGES; III. CELLS; IV. MATERIALS; V. GENERAL SCIENTIFIC ISSUES; VI. SOCIAL CHALLENGES; VII. REFERENCES; Chapter Two: The Challenge of Imitating Nature; I. INTRODUCTION; II. CELL TECHNOLOGY; III. CONSTRUCT TECHNOLOGY; IV. INTEGRATION INTO THE LIVING SYSTEM

V. CONCLUDING DISCUSSIONVI. ACKNOWLEDGMENTS; VII. REFERENCES; Chapter Three: Moving into the Clinic; I. INTRODUCTION; II. HISTORY OF CLINICAL TISSUE ENGINEERING; III. STRATEGIES TO ADVANCE TOWARD THE CLINIC; IV. BRINGING TECHNOLOGY PLATFORMS TO THE CLINICAL SETTING; V. TRANSITION TO CLINICAL TESTING; VI. ESTABLISHING A REGULATORY PATHWAY; VII. CONCLUSIONS; VIII. ACKNOWLEDGMENTS; IX. REFERENCES; Chapter Four: Future Perspectives; I. CLINICAL NEED; II. CURRENT STATE OF THE FIELD; III. CURRENT CHALLENGES; IV. FUTURE DIRECTIONS; V. FUTURE CHALLENGES; VI. REFERENCES

Part One: The Basis of Growth and DifferentiationChapter Five: Molecular Biology of the Cell; I. INTRODUCTION; II. THE CELL NUCLEUS; III. THE CYTOPLASM; IV. GROWTH AND DEATH; V. CYTOSKELETON; VI. CELL ADHESION MOLECULES; VII. EXTRACELLULAR MATRIX; VIII. CULTURE MEDIA; IX. CELLS IN TISSUES; X. FURTHER READING; Chapter Six: Organization of Cells into Higher-Ordered Structures; I. INTRODUCTION; II. MOLECULAR MECHANISMS OF THE EMT; III. THE EMT TRANSCRIPTIONAL PROGRAM; IV. MOLECULAR CONTROL OF THE EMT; V. CONCLUSION; VI. REFERENCES; Chapter Seven: The Dynamics of Cell-ECM Interactions

I. INTRODUCTIONII. CELL-ECM INTERACTIONS; III. SIGNAL TRANSDUCTION EVENTS DURING CELL-ECM INTERACTIONS; IV. RELEVANCE FOR TISSUE ENGINEERING; V. REFERENCES; Chapter Eight: Matrix Molecules and Their Ligands; I. INTRODUCTION; II. COLLAGENS - MAJOR CONSTITUENTS OF ECM; III. ELASTIC FIBERS AND MICROFIBRILS; IV. OTHER MULTIFUNCTIONAL PROTEINS IN ECM; V. PROTEOGLYCANS - MULTIFUNCTIONAL MOLECULES IN THE EXTRACELLULAR MATRIX AND ON CELL SURFACES; VI. CONCLUSION; VII. REFERENCES; Chapter Nine: Morphogenesis and Tissue Engineering; I. INTRODUCTION; II. BONE MORPHOGENETIC PROTEINS (BMPs)

III. CARTILAGE-DERIVED MORPHOGENETIC PROTEINS (CDMPs)IV. PLEIOTROPY AND THRESHOLDS; V. BMPs BIND TO EXTRACELLULAR MATRIX; VI. BMP RECEPTORS; VII. RESPONDING STEM CELLS; VIII. MORPHOGENS AND GENE THERAPY; IX. BIOMIMETIC BIOMATERIALS; X. TISSUE ENGINEERING OF BONES AND JOINTS; XI. FUTURE CHALLENGES; XII. ACKNOWLEDGMENTS; XIII. REFERENCES; Chapter Ten: Gene Expression, Cell Determination, and Differentiation; I. INTRODUCTION; II. DETERMINATION AND DIFFERENTIATION; III. MyoD AND THE bHLH FAMILY OF DEVELOPMENTAL REGULATORY FACTORS; IV. MEFs - COREGULATORS OF DEVELOPMENT; V. PAX IN DEVELOPMENT

VI. CONCLUSIONS

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-11901-6

9786611119010

0-08-054884-9

OCLC:

476083764